Announcements Trials
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Phase

Phase 2 1Phase 1/2 1Phase 1 1

Status

Terminated 2Completed 1

Sponsor Class

OTHER 7NETWORK 3NIH 1INDUSTRY 1

Study Type

Interventional 3

Sponsor

Cancer Type

CNS 3Sarcoma 1Other hematologic neoplasm 1Lymphoid 1

Conditions

Ovarian Neoplasms 8Neuroblastoma 8Carcinoma, Ovarian Epithelial 6Uterine Cervical Neoplasms 4Fallopian Tube Neoplasms 4Sarcoma 3Leukemia 3Ganglioneuroblastoma 3Central Nervous System Neoplasms 3Precursor Cell Lymphoblastic Leukemia-Lymphoma 2Oligodendroglioma 2Neuroectodermal Tumors, Primitive, Peripheral 2Brenner Tumor 2Brain Neoplasms 2Wilms Tumor 1Rhabdomyosarcoma 1Rhabdoid Tumor 1Recurrence 1Pleuropulmonary blastoma 1Optic Nerve Glioma 1Neoplasms, Unknown Primary 1Meningeal Carcinomatosis 1Medulloblastoma 1Malignant mesenchymal tumor 1Lymphoma, Large-Cell, Anaplastic 1Lymphoma 1Lung Neoplasms 1Localized Extraskeletal Ewing Sarcoma 1Leukemia, Promyelocytic, Acute 1Leukemia, Myelomonocytic, Juvenile 1

Interventions

Radiotherapy 38Temozolomide 27Vincristine 15Chemotherapy, Adjuvant 11Carboplatin 11Filgrastim 10Granulocyte Colony-Stimulating Factor 9Etoposide 9Cyclophosphamide 9Lomustine 8Carmustine 7Cisplatin 6Peripheral Blood Stem Cell Transplantation 5etoposide phosphate 4Thiotepa 4Radiotherapy, Intensity-Modulated 4Radiotherapy, Conformal 4Procarbazine 4Neoadjuvant Therapy 4Irinotecan 4Immunohistochemistry 4Gene Expression Profiling 4Topotecan 3Radiosurgery 3Radiation 3lonafarnib 2Psychiatric Rehabilitation 2Microarray Analysis 2Methotrexate 2Mesna 2

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
NETWORK × Central Nervous System Neoplasms × Topotecan × Clear all
NCT00003372 2020-04-08

Topotecan in Treating Patients With Recurrent Brain Tumors

Canadian Cancer Trials Group

Phase 2 Completed
17 enrolled
CNS

Brain Neoplasms, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT00107471 2013-12-10

Topotecan, G-CSF, and Radiation Therapy in Treating Young Patients With Newly Diagnosed Brain Stem Glioma

Children's Oncology Group

Phase 1/2 Terminated
7 enrolled
CNS

Brain Neoplasms, Central Nervous System Neoplasms

NCT00112619 2011-06-30

Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors

Pediatric Brain Tumor Consortium

Phase 1 Terminated
19 enrolled
CNSLymphoidOther hematologic neoplasmSarcoma

Familial ependymoma, Astrocytoma, Burkitt Lymphoma, Leukemia, Lymphoma, Medulloblastoma, Neoplasms, Unknown Primary, Oligodendroglioma, Recurrence, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor, Optic Nerve Glioma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Dendritic Cell Sarcoma, Interdigitating, Meningeal Carcinomatosis

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