Clinical Trials Browser

Bile Duct Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma, Disease Progression

NCT06739252 2026-01-28

Perioperative Treatment of High-risk Resectable CCA With HAIC Plus A+T: Neobrave CCA

Phase 2 Terminated

1 enrolled

Gastrointestinal

Cirrhosis, Familial, with Pulmonary Hypertension, Cholangiocarcinoma, Klatskin Tumor

NCT05563272 2025-07-10

STARBURST

Phase 2 Terminated

11 enrolled

CNSGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Nasopharyngeal Carcinoma, Mesothelioma, Malignant, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Carcinoma, Hepatocellular, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma, Small Cell Lung Carcinoma

NCT06370663 2025-06-25

First-line Treatment for Unresectable Locally Advanced Distal Cholangiocarcinoma Combining Radiotherapy and HAIC

Phase 2 Terminated

1 enrolled

Gastrointestinal

Cholangiocarcinoma

NCT05565794 2025-04-13

Pemigatinib After Curative Local Therapy in Advanced iCCA With FGFR2 Fusion/Rearrangements

Phase 2 Terminated

2 enrolled

Gastrointestinal

Cholangiocarcinoma

NCT04383210 2025-04-03

Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors

Phase 2 Terminated

54 enrolled 11 charts

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Fibromatosis, Gingival, 2, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Uterine Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT04866836 2025-03-21

A Study of Tislelizumab Combined With Radiotherapy as the Second-line Treatment of Advanced Biliary Malignant Tumors

Phase 2 Terminated

20 enrolled

Gastrointestinal

Cholangiocarcinoma

NCT02878473 2024-12-13

LT for iCCA

Phase 2 Terminated

2 enrolled

Gastrointestinal

Cholangiocarcinoma

NCT05012397 2024-10-17

Milademetan in Advanced/Metastatic Solid Tumors

Phase 2 Terminated

40 enrolled 13 charts

DermatologicEndocrineGastrointestinalGenitourinaryGynecologicSarcomaThoracic

Testicular Germ Cell Tumor, Adenocarcinoma of Lung, Biliary Tract Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma, Stomach Neoplasms, Adrenocortical Carcinoma, Cholangiocarcinoma

NCT05009953 2024-07-11

Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer

Phase 2 Terminated

17 enrolled

Gastrointestinal

Gallbladder Neoplasms, Cholangiocarcinoma

NCT02452970 2024-04-24

EPIC

Phase 2 Terminated

4 enrolled 6 charts

Gastrointestinal

Cholangiocarcinoma

NCT04099888 2023-09-11

RELEASE

Phase 2 Terminated

41 enrolled 17 charts

Gastrointestinal

Bile Duct Neoplasms, Cholangiocarcinoma

NCT04566133 2023-08-21

Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).

Phase 2 Terminated

2 enrolled 9 charts

Gastrointestinal

Bile Duct Neoplasms, Biliary Tract Neoplasms, Cholangiocarcinoma

NCT04644315 2023-08-07

ALpha-T

Phase 2 Terminated

1 enrolled 5 charts

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Renal Cell, Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Melanoma, Neoplasms, Neoplasms by Site, Ovarian Neoplasms, Pancreatic Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Salivary Gland Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT02150967 2023-07-03

A Phase II, Single Arm Study of BGJ398 in Patients With Advanced Cholangiocarcinoma

Phase 2 Terminated

143 enrolled 25 charts 1 FDA

Gastrointestinal

Cholangiocarcinoma

NCT04076761 2022-12-01

MOCHA

Phase 2 Terminated

8 enrolled

Gastrointestinal

Bile Duct Neoplasms, Cholangiocarcinoma

NCT02415036 2022-10-17

Melphalan for Use With the Hepatic Delivery System Treatment in Patients With Unresectable Hepatocellular Carcinoma or Intra Hepatic Cholangiocarcinoma

Phase 2 Terminated

17 enrolled

Gastrointestinal

Carcinoma, Hepatocellular, Cholangiocarcinoma

NCT04727541 2022-05-23

NEOBIL

Phase 2 Terminated

3 enrolled

Gastrointestinal

Biliary Tract Neoplasms, Cholangiocarcinoma

NCT04648319 2022-02-23

A Study of BMS-936558 With SBRT After Induction Chemotherapy in Cholangiocarcinoma

Phase 2 Terminated

1 enrolled

Gastrointestinal

Cholangiocarcinoma

NCT02982720 2022-02-16

Evaluating Combination Immunotherapy for Advanced Cholangiocarcinoma With Pembrolizumab and PEG-Intron

Phase 2 Terminated

4 enrolled 9 charts

Gastrointestinal

Cholangiocarcinoma

NCT01855724 2018-11-07

Clinical Trial to Investigate the Efficacy of Treatment With Gemcitabine/Pazopanib in Patients With Biliary Tree Cancer

Phase 2 Terminated

29 enrolled

Gastrointestinal

Gallbladder Neoplasms, Cholangiocarcinoma

NCT02254681 2018-10-03

Low-Dose Radiation Therapy to the Whole Liver With Gemcitabine and Cisplatin in IHC

Phase 2 Terminated

6 enrolled 12 charts

Gastrointestinal

Cholangiocarcinoma

NCT00832637 2018-06-29

Gem-ox

Phase 2 Terminated

33 enrolled 9 charts

Gastrointestinal

Bile Duct Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Cholangiocarcinoma

NCT02374489 2018-04-05

A Phase II Trial of LDK378 in ROS1 and /or ALK Over-expressed Advanced Intrahepatic or Hilar Cholangiocarcinoma

Phase 2 Terminated

9 enrolled

Gastrointestinal

Cholangiocarcinoma

NCT02638909 2018-04-02

Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal Malignancies

Phase 2 Terminated

4 enrolled

Gastrointestinal

Adenocarcinoma Of Esophagus, Cholangiocarcinoma

NCT01151761 2016-07-29

Phase II SBRT & Chemo for Unresectable Cholangiocarcinoma Followed by Liver Transplantation

Phase 2 Terminated

2 enrolled 9 charts

Gastrointestinal

Bile Duct Neoplasms, Gallbladder Neoplasms, Liver Neoplasms, Cholangiocarcinoma

NCT00975039 2016-04-18

Study Using WST11 in Patients With Non-Resectable or Inoperable Cholangiocarcinoma

Phase 2 Terminated

8 enrolled

Gastrointestinal

Carcinoma, Cholangiocarcinoma

NCT02479178 2016-04-14

iNSITE2

Phase 2 Terminated

73 enrolled

GastrointestinalGenitourinaryGynecologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Cholangiocarcinoma

NCT00983541 2015-08-19

Chemoradiation +Gemcitabine +Continuous 5-FU (Fluorouracil) Followed by High Dose Brachytherapy/Stereotactic Radiation Boost in Locally Advanced Intra/Extrahepatic Cholangiocarcinoma

Phase 2 Terminated

1 enrolled 4 charts

Gastrointestinal

Liver Neoplasms, Neoplasms, Cholangiocarcinoma

Clinical Trials

BOLSTER

Perioperative Treatment of High-risk Resectable CCA With HAIC Plus A+T: Neobrave CCA

STARBURST

First-line Treatment for Unresectable Locally Advanced Distal Cholangiocarcinoma Combining Radiotherapy and HAIC

Pemigatinib After Curative Local Therapy in Advanced iCCA With FGFR2 Fusion/Rearrangements

Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors

A Study of Tislelizumab Combined With Radiotherapy as the Second-line Treatment of Advanced Biliary Malignant Tumors

LT for iCCA

Milademetan in Advanced/Metastatic Solid Tumors

Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer

EPIC

RELEASE

Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).

ALpha-T

A Phase II, Single Arm Study of BGJ398 in Patients With Advanced Cholangiocarcinoma

MOCHA

Melphalan for Use With the Hepatic Delivery System Treatment in Patients With Unresectable Hepatocellular Carcinoma or Intra Hepatic Cholangiocarcinoma

NEOBIL

A Study of BMS-936558 With SBRT After Induction Chemotherapy in Cholangiocarcinoma

Evaluating Combination Immunotherapy for Advanced Cholangiocarcinoma With Pembrolizumab and PEG-Intron

Clinical Trial to Investigate the Efficacy of Treatment With Gemcitabine/Pazopanib in Patients With Biliary Tree Cancer

Low-Dose Radiation Therapy to the Whole Liver With Gemcitabine and Cisplatin in IHC

Gem-ox

A Phase II Trial of LDK378 in ROS1 and /or ALK Over-expressed Advanced Intrahepatic or Hilar Cholangiocarcinoma

Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal Malignancies

Phase II SBRT & Chemo for Unresectable Cholangiocarcinoma Followed by Liver Transplantation

Study Using WST11 in Patients With Non-Resectable or Inoperable Cholangiocarcinoma

iNSITE2

Chemoradiation +Gemcitabine +Continuous 5-FU (Fluorouracil) Followed by High Dose Brachytherapy/Stereotactic Radiation Boost in Locally Advanced Intra/Extrahepatic Cholangiocarcinoma