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Phase

Phase 1 1

Status

Completed 1

Sponsor Class

NIH 7OTHER 5NETWORK 1

Study Type

Interventional 1

Sponsor

Cancer Type

CNS 1

Conditions

Central Nervous System Neoplasms 27Astrocytoma 15Oligodendroglioma 14Glioblastoma 14Gliosarcoma 12Glioma 11Brain Neoplasms 11Ependymoma 4Spinal Cord Neoplasms 3Neuroblastoma 3Somatostatinoma 2Neoplasm Metastasis 2Melanoma 2Medulloblastoma 2Lymphoma 2Lung Neoplasms 2Carcinoma, Non-Small-Cell Lung 2Adenoma, Islet Cell 2Sarcoma, Ewing 1Rhabdoid Tumor 1Precursor Cell Lymphoblastic Leukemia-Lymphoma 1Optic Nerve Glioma 1Neurotoxicity Syndromes 1Neuroectodermal Tumors, Primitive 1Leukemia 1Insulinoma 1Glucagonoma 1Glioma, Subependymal 1Gastrointestinal Stromal Tumors 1Gastrinoma 1

Interventions

Vincristine 2Psychiatric Rehabilitation 2Irinotecan 2palbociclib 1lonafarnib 1laromustine 1etoposide phosphate 1azurin (50-77) 1Watchful Waiting 1Topotecan 1Thiotepa 1Temozolomide 1Semaxinib 1Peripheral Blood Stem Cell Transplantation 1N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine 1Granulocyte Colony-Stimulating Factor 1Filgrastim 1Etoposide 1Drug Therapy 1Cyclophosphamide 1Cisplatin 1Carboplatin 1Busulfan 13-(4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
NETWORK × Choroid Plexus Neoplasms × Temozolomide × Clear all
NCT00138216 2023-10-02

Temozolomide, Vincristine, and Irinotecan in Treating Young Patients With Refractory Solid Tumors

Children's Oncology Group

Phase 1 Completed
42 enrolled
CNS

Familial ependymoma, Astrocytoma, Medulloblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor, Optic Nerve Glioma

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