Announcements Trials
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Phase

Phase 2 2Phase 3 1

Status

Completed 2Recruiting 1

Sponsor Class

OTHER 3

Study Type

Interventional 3

Sponsor

Cancer Type

CNS 1Breast 1

Conditions

Brain Neoplasms 9Lung Neoplasms 3Glioblastoma 3Cognitive Dysfunction 3Breast Neoplasms 3Small Cell Lung Carcinoma 2Prostatic Neoplasms 2Carcinoma, Non-Small-Cell Lung 2Carcinoma, Hepatocellular 2Tobacco Use Disorder 1Recurrence 1Rectal Neoplasms 1Peripheral Nervous System Diseases 1Neoplasms, Germ Cell and Embryonal 1Neoplasms 1Neoplasm Metastasis 1Motor Activity 1Melanoma 1Gliosarcoma 1Gastrointestinal Neoplasms 1Fibrosis 1Epilepsy 1Ependymoma 1Craniopharyngioma 1Colorectal Neoplasms 1Colonic Neoplasms 1Central Nervous System Neoplasms 1Carcinoma, Renal Cell 1Breast Cancer Early Stage Breast Cancer (Stage 1-3) 1

Interventions

Exercise 6Transcranial Direct Current Stimulation 4Neuropsychological Tests 4Walking 3Memantine 3Tablets 2Standard of Care 2Patient Reported Outcome Measures 2Methods 2Electroencephalography 2Donepezil 2Cognitive Behavioral Therapy 2mazdutide 1lime 1enzalutamide 1blueberry extract 1beta Carotene 1acetaminophen, aspirin, caffeine drug combination 1Vitamin E 1Vitamin D 1Ultraviolet Therapy 1Transcranial Magnetic Stimulation 1Time 1Therapeutics 1Tai Ji 1Surveys and Questionnaires 1Sugars 1Sodium Chloride 1Sirolimus 1Silymarin 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
OTHER × Cognitive Dysfunction × Memantine × Clear all
NCT06727773 2026-05-06

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

UNC Lineberger Comprehensive Cancer Center

Phase 2 Recruiting
90 enrolled
Breast

Breast Neoplasms, Motor Activity, Cognitive Dysfunction

NCT02360215 2025-04-23

Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases

NRG Oncology

Phase 3 Completed
518 enrolled 40 charts
CNS

Brain Neoplasms, Cognitive Dysfunction

NCT04033419 2023-04-20

Memantine for Prevention of Cognitive Decline in Patients With Breast Cancer

UNC Lineberger Comprehensive Cancer Center

Phase 2 Completed
55 enrolled 21 charts

Cognitive Dysfunction

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