Clinical Trials

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03365882 2026-02-10

S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery

240 enrolled 14 charts

Colonic Neoplasms, Rectal Neoplasms

NCT04109924 2026-02-10

TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study

42 enrolled 12 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00556413 2026-02-05

Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

42 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05062889 2026-02-03

ERASE-CRC

Phase 2 Suspended

477 enrolled

Colonic Neoplasms

NCT05678257 2025-09-12

A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer

180 enrolled 16 charts

Phase 2 Active not recruiting

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT00492999 2025-08-17

Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

64 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT02138617 2025-05-18

Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI + BevacizumabTreated Metastatic Colorectal Cancer

100 enrolled 13 charts

Colonic Neoplasms

NCT01814501 2025-02-05

Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab

16 enrolled 11 charts

Phase 2 Not yet recruiting

Colonic Neoplasms, Rectal Neoplasms

NCT06665087 2024-10-30

CGA Guided Ultrafractionated RT and First-line Systemic Treatment in Elderly or Frail Patients with MCRC

110 enrolled

Phase 2 Not yet recruiting

Colonic Neoplasms, Rectal Neoplasms

NCT06652412 2024-10-28

CGA Guided Ultrafractionated RT and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized CRC

124 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT00098787 2023-07-05

Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer

247 enrolled 10 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01079780 2023-06-28

Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy

136 enrolled 13 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04189055 2023-06-12

CETIDYL

72 enrolled

Colonic Neoplasms

NCT05278351 2023-03-31

Tislelizumab Plus Cetuximab and Irinotecan vs Third-line Standard-of-care in Refractory mCRC

87 enrolled

Colonic Neoplasms

NCT03493061 2023-02-15

A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRCLM

60 enrolled

Colonic Neoplasms

NCT00467142 2022-11-01

OMEGA

62 enrolled 6 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00314353 2021-10-06

Study of Bevacizumab Combined With Capecitabine and Either Oxaliplatin or Irinotecan as First Course of Treatment for Patients With Colorectal Cancer That Has Spread Beyond the Colon

7 enrolled 5 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00655499 2021-09-21

PIMABI

65 enrolled 18 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03484195 2021-04-19

Neoadjuvant FOLFOXIRI Chemotherapy in Patients With Locally Advanced Colon Cancer

30 enrolled

Colonic Neoplasms

NCT00066274 2021-03-02

Comparison of Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00423696 2021-02-17

Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

145 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00628810 2020-11-09

Combination Chemotherapy and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

86 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03608046 2020-10-22

AVETUXIRI

59 enrolled

Colonic Neoplasms

NCT00002933 2020-07-27

Irinotecan in Treating Patients With Metastatic or Recurrent Colorectal Cancer

21 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00541125 2020-03-30

G-CSF in Preventing Neutropenia During First-Line Treatment With Chemotherapy and Bevacizumab in Patients With Metastatic Colorectal Cancer

20 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00940316 2019-05-07

Dual Epidermal Growth Factor Receptor Inhibition With Erlotinib and Panitumumab With or Without Chemotherapy for Advanced Colorectal Cancer

28 enrolled 11 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01925274 2019-01-08

A Study Of PF-05212384 Plus Irinotecan Vs Cetuximab Plus Irinotecan In Patients With KRAS And NRAS Wild Type Metastatic Colorectal Cancer

19 enrolled 32 charts

Colonic Neoplasms, Colorectal Neoplasms

NCT00418938 2018-10-17

SPIRITT - Second-Line Panitumumab Irinotecan Treatment Trial

266 enrolled 17 charts

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00845039 2018-07-02

FC-4

4 enrolled 9 charts

Colonic Neoplasms, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00381862 2017-06-12

Phase II Trial of Aprepitant & Palonosetron for CINV Prevention w FOLFOX

54 enrolled 7 charts

Colonic Neoplasms, Nausea, Rectal Neoplasms, Vomiting, Colorectal Neoplasms

NCT00449163 2017-05-11

Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer

25 enrolled 10 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00004005 2017-04-26

Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary Origin

12 enrolled

Colonic Neoplasms, Neoplasms, Unknown Primary, Rectal Neoplasms, Colorectal Neoplasms

NCT00030563 2017-04-17

Surgery With or Without Radiofrequency Ablation Followed by Irinotecan in Treating Patients With Colorectal Cancer That is Metastatic to the Liver

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00588900 2017-04-05

Irinotecan and Cediranib in Treating Patients With Metastatic Colorectal Cancer That Did Not Respond to Previous Oxaliplatin, Fluoropyrimidine, and Bevacizumab

5 enrolled 5 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00127036 2017-03-23

Trial for Microarray Analysis of Colon Cancer Outcome-A (MACCO-A)

65 enrolled 8 charts

Adenocarcinoma, Colonic Neoplasms, Rectal Neoplasms

NCT02046538 2017-01-25

Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer

Phase 2 Withdrawn

Colonic Neoplasms, Rectal Neoplasms

NCT00016952 2016-12-07

Irinotecan or Fluorouracil Plus Leucovorin in Treating Patients With Previously Treated Metastatic Colorectal Cancer

19 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00080951 2016-12-07

Irinotecan, Fluorouracil, Leucovorin, and Oxaliplatin as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

14 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01322815 2016-08-15

A Pilot Trial of GI-4000 Plus Bevacizumab and Either FOLFOX or FOLFIRI

11 enrolled 8 charts

Colonic Neoplasms, Neoplasm Metastasis

NCT01320683 2016-07-19

Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer

1 enrolled 2 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00336856 2016-07-12

Irinotecan and Cetuximab for Colorectal Cancer as Second Line Therapy

35 enrolled 7 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00063960 2016-07-06

Hepatic Arterial Infusion With Floxuridine and Systemic Irinotecan After Surgery in Treating Patients With Hepatic (Liver) Metastases From Colorectal Cancer

94 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00022698 2016-04-15

Capecitabine and Irinotecan in Treating Patients With Locally Advanced, Recurrent, or Metastatic Colorectal Cancer

67 enrolled 15 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00332163 2016-02-23

STEPP

95 enrolled 23 charts

Colonic Neoplasms, Exanthema, Rectal Neoplasms, Colorectal Neoplasms

NCT01703910 2015-10-09

Study of Individualized Therapies Selection for Patients With Metastatic Colorectal Carcinoma According to the Therapeutic

29 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms

NCT01375816 2015-06-04

PEPCOL

55 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00077298 2015-04-15

Bevacizumab and Cetuximab With or Without Irinotecan in Treating Patients With Irinotecan-Refractory Metastatic Colorectal Cancer

70 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT01205711 2014-07-08

FOLFERA

111 enrolled