Clinical Trials

GastrointestinalGynecologic

17 enrolled

Colonic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms, Microsatellite Instability

NCT05578092 2026-02-19

A Phase 1 Study of MRTX0902 in Solid Tumors With Mutations in the KRAS MAPK Pathway

64 enrolled

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Colorectal Neoplasms

NCT06457997 2026-01-29

A Study of PHN-010 in Patients With Advanced Solid Tumors

GastrointestinalGynecologicThoracic

26 enrolled

Carcinoma, Uterine Cervical Neoplasms, Colonic Neoplasms, Lung Neoplasms, Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms

NCT04294160 2025-12-24

A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer

122 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT02784795 2025-08-21

A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors

BreastGastrointestinalSarcoma

94 enrolled 28 charts

Breast Neoplasms, Colonic Neoplasms, Sarcoma, Cholangiocarcinoma

NCT04209465 2025-04-17

MasterKey-01

BreastGastrointestinalGenitourinaryGynecologicThoracic

91 enrolled 26 charts

Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT05737706 2025-04-06

Study of MRTX1133 in Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation

63 enrolled

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT04108481 2025-03-28

iRE-C

5 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04975256 2024-12-16

Adagrasib in Combination With BI 1701963 in Patients With Cancer (KRYSTAL 14)

7 enrolled

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms

NCT02980029 2024-10-22

TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.

23 enrolled

Colonic Neoplasms

NCT03621982 2024-06-13

Study of ADCT-301 in Patients With Selected Advanced Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

78 enrolled 39 charts

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Triple Negative Breast Neoplasms

NCT04873895 2024-04-26

TACE-Ax-HCQ

5 enrolled

Colonic Neoplasms, Colorectal Neoplasms

NCT05121948 2024-03-08

A Study of HC-7366 to Establish the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D)

GastrointestinalGenitourinaryHead & NeckThoracic

35 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms

NCT01769222 2024-01-24

Ipilimumab and Local Radiation for Selected Solid Tumors

DermatologicGastrointestinalLymphoidOther hematologic neoplasm

3 enrolled 5 charts

Burkitt Lymphoma, Colonic Neoplasms, Immunoblastic Lymphadenopathy, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Melanoma, Mycosis Fungoides, Rectal Neoplasms, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, T-Cell, Peripheral, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Intraocular Lymphoma

NCT00006046 2023-10-04

Monoclonal Antibody Therapy in Treating Patients With Advanced Colorectal Cancer

7 enrolled 8 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01239095 2023-02-22

Oral Green Tea Extract and Milk Thistle Extract to Colorectal Cancer Patients Undergoing Resection

23 enrolled

Colonic Neoplasms

NCT04044430 2023-01-09

Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer

2 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02628535 2022-02-08

Safety Study of MGD009 in B7-H3-expressing Tumors

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

67 enrolled

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Melanoma, Mesothelioma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Thyroid Neoplasms

NCT01285102 2021-12-20

Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer

4 enrolled 6 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00041691 2021-08-19

Safety Study of 90Y-hMN14 to Treat Colorectal Cancer Patients With Limited Residual Disease After Surgery

30 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03449030 2021-03-22

A Study of TAK-164 in Participants With Advanced Gastrointestinal (GI) Cancer Expressing Guanylyl Cyclase C (GCC)

31 enrolled 28 charts

Colonic Neoplasms, Gastrointestinal Neoplasms

NCT02687009 2020-02-19

A Study of Niclosamide in Patients With Resectable Colon Cancer

1 enrolled

Colonic Neoplasms

NCT00827580 2018-05-30

Eniluracil Hand Foot Syndrome

3 enrolled

BreastGastrointestinal

Breast Neoplasms, Colonic Neoplasms

NCT02110953 2018-02-26

Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver

2 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT01012362 2017-12-28

Study of Pazopanib and Ixabepilone in Patients With Solid Tumors

BreastGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

31 enrolled 12 charts

Breast Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Pancreatic Neoplasms, Sarcoma

NCT01302405 2017-08-17

Safety and Efficacy Study of PRI-724 in Subjects With Advanced Solid Tumors

23 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms

NCT02102412 2017-08-01

First in Man Aer-O-Scope

101 enrolled

Colonic Neoplasms

NCT00072098 2017-01-11

Interleukin-12 Gene in Treating Patients With Liver Metastases Secondary to Colorectal Cancer

22 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00358397 2016-10-14

One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy

GastrointestinalGenitourinarySarcomaThoracic

2 enrolled

Hypoxia, Urinary Bladder Neoplasms, Colonic Neoplasms, Lung Neoplasms, Necrosis, Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Sarcoma, Stomach Neoplasms

NCT01238965 2015-05-27

Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Who Did Not Respond to Previous Fluorouracil-Based Chemotherapy

7 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT01198535 2015-05-18

Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer

60 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT01440127 2015-03-26

Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related Pharmacodynamic Markers

9 enrolled

Colonic Neoplasms

NCT01233505 2014-04-02

Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors

BreastGastrointestinalGynecologic

16 enrolled

Carcinoma, Ovarian Epithelial, Breast Neoplasms, Colonic Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT00088933 2014-03-31

Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With Metastatic Lung Cancer or Metastatic Colorectal Cancer

60 enrolled

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Rectal Neoplasms, Small Cell Lung Carcinoma

NCT00689065 2013-11-01

Safety Study of CALAA-01 to Treat Solid Tumor Cancers

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

24 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Skin Neoplasms, Thyroid Neoplasms, Endometrial Neoplasms

NCT00049608 2013-06-19

Gemcitabine Combined With Mistletoe in Treating Patients With Advanced Solid Tumors

BreastGastrointestinalThoracic

51 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Breast Neoplasms, Male

NCT00937482 2013-03-08

Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

18 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Melanoma, Rectal Neoplasms, Breast Neoplasms, Male

NCT01126450 2012-03-20

Lenalidomide and Cetuximab in Treating Patients With Metastatic Colorectal Cancer

3 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT01212887 2012-02-28

Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating Patients With Cancer

BreastGastrointestinalGynecologicThoracic

14 enrolled

Carcinoma, Ovarian Epithelial, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Small Cell Lung Carcinoma

NCT00296062 2012-01-16

Dose Dense Therapy and Bevacizumab in Solid Tumors and Colorectal Cancer

12 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00494611 2011-05-19

A Study of the Perioperative Use of Cetuximab in Colon Cancer Patients

25 enrolled

Colonic Neoplasms

NCT00249301 2008-04-01

A Study of MLN8054 in Patients With Advanced Solid Tumors