Clinical Trials

Phase 2 Active not recruiting

Colonic Neoplasms

NCT02465060 2026-05-26

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

6,452 enrolled 1 FDA

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellThoracic

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Glioma, Carcinoma, Hepatocellular, Lung Neoplasms, Lymphoma, Melanoma, Multiple Myeloma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT00469339 2026-05-22

Risk Communication Within Mexican-American Families

498 enrolled

Breast Neoplasms, Cardiovascular Diseases, Colonic Neoplasms, Diabetes Mellitus

NCT03190941 2026-05-22

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Phase 1/2 Recruiting

110 enrolled

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT03745326 2026-05-19

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

Phase 1/2 Terminated

5 enrolled 14 charts

Phase 1 Active not recruiting

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT04704661 2026-05-13

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

51 enrolled

BreastGastrointestinalGynecologicHead & NeckSarcoma

Breast Neoplasms, Carcinosarcoma, Colonic Neoplasms, Neoplasm Metastasis, Salivary Gland Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT04955808 2026-05-13

Biospecimen Collection in Identifying Genetic Changes in Patients With Breast, Prostate, Colorectal, Liver, or Kidney Cancer or Multiple Myeloma Undergoing Surgery

Suspended

2,400 enrolled

BreastGastrointestinalGenitourinaryPlasma cell

Breast Neoplasms, Carcinoma, Renal Cell, Colonic Neoplasms, Carcinoma, Hepatocellular, Multiple Myeloma, Prostatic Neoplasms

NCT02595957 2026-05-07

Genomic Services Research Program

Recruiting

5,000 enrolled

Phase 3 Active not recruiting

Breast Neoplasms, Colonic Neoplasms

NCT02912559 2026-05-05

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

712 enrolled 14 charts

Phase NA Active not recruiting

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Repair-Deficiency Disorders

NCT01696981 2026-04-30

Screening for Colorectal Cancer in Older Patients (PLCO Screening Trial)

154,900 enrolled 15 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00034216 2026-04-21

Collection of Blood From Patients With Cancer

Recruiting

1,750 enrolled

Phase 2 Active not recruiting

Breast Neoplasms, Colonic Neoplasms, Liver Neoplasms, Lung Neoplasms, Neoplasms, Prostatic Neoplasms

NCT05308446 2026-04-21

Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation

84 enrolled

Phase 1 Active not recruiting

Colonic Neoplasms, Rectal Neoplasms

NCT02381561 2026-04-13

Ropidoxuridine in Treating Patients With Advanced Gastrointestinal Cancer Undergoing Radiation Therapy

19 enrolled

Colonic Neoplasms, Esophageal Neoplasms, Liver Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT00451022 2026-04-07

Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies

Recruiting

750 enrolled

Phase 1/2 Active not recruiting

Breast Neoplasms, Colonic Neoplasms, Liver Neoplasms, Lung Neoplasms, Prostatic Neoplasms

NCT04708470 2026-04-06

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

55 enrolled

GastrointestinalGenitourinaryGynecologicHead & Neck

Anus Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT06885697 2026-02-17

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

Phase 1 Recruiting

100 enrolled

GastrointestinalGynecologicOther solid neoplasmThoracic

Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thymoma, Thymus Neoplasms

NCT00002968 2025-12-29

Edrecolomab in Treating Patients With Stage II Colon Cancer

Phase 3 Completed

2,100 enrolled

Colonic Neoplasms

NCT04465214 2025-12-15

Mobile Sensor Technologies to Assess General Symptomology of People With Cancer

GastrointestinalGenitourinaryThoracic

49 enrolled

Colonic Neoplasms, Lung Neoplasms, Neoplasms, Prostatic Neoplasms

NCT02767986 2024-09-03

Where Culture Meets Genetics: Exploring Latinas Causal Attributions of Breast and Colon Cancer and Models of Disease Inheritance

22 enrolled

Breast Neoplasms, Colonic Neoplasms

NCT01851369 2024-05-08

TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas

Phase 1/2 Completed

93 enrolled 27 charts

GastrointestinalLymphoid

Colonic Neoplasms, Lymphoma

NCT00019006 2024-03-04

Vaccine Therapy in Treating Patients With Colon, Pancreatic, or Lung Cancer

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Genetic Diseases, Inborn, Small Cell Lung Carcinoma

NCT00020267 2024-03-04

Vaccine Therapy in Treating Patients With Metastatic Cancer

BreastDermatologicGastrointestinalSarcomaThoracic

Uveal Melanoma, Bone Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Eye Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Rectal Neoplasms, Recurrence, Sarcoma, Osteosarcoma, Skin Neoplasms, Colorectal Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Breast Neoplasms, Male, Muscle Neoplasms, Genetic Diseases, Inborn, Histiocytoma, Malignant Fibrous

NCT00407654 2024-03-04

VEGF Trap in Treating Patients With Previously Treated Metastatic Colorectal Cancer

75 enrolled 15 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00019760 2023-10-31

Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver

Colonic Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Genetic Diseases, Inborn

NCT03592641 2023-10-17

Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer

Phase 2 Terminated

5 enrolled 8 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03801915 2023-03-21

Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers

10 enrolled 14 charts

Colonic Neoplasms, Pancreatic Neoplasms, Cholangiocarcinoma

NCT03384316 2020-09-09

Multi-Targeted Recombinant Ad5 (CEA/MUC1/Brachyury) Based Immunotherapy Vaccine Regimen in People With Advanced Cancer

11 enrolled 18 charts

DermatologicGastrointestinal

Adenoviridae Infections, Breast Neoplasms, Colonic Neoplasms, Lung Neoplasms, Neoplasms, Prostatic Neoplasms

NCT03480152 2020-06-02

Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by the Autologous Cancer

Phase 1/2 Terminated

5 enrolled 11 charts

Colonic Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Melanoma, Neoplasm Metastasis, Urogenital Neoplasms

NCT00079274 2020-05-13

Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon Cancer

Phase 3 Completed

3,397 enrolled 24 charts

Colonic Neoplasms

NCT01254617 2020-03-13

ADCC

GastrointestinalHead & Neck

24 enrolled

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Colonic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms

NCT01287130 2019-12-17

AZD6244 With Cetuximab for Solid Tumors and Colorectal Cancer

10 enrolled

Colonic Neoplasms, Colorectal Neoplasms

NCT01346280 2019-12-17

Evaluation of Cancer Care Coordination in the National Cancer Institutes Community Cancer Center Programs

Phase EARLY_PHASE1 Completed

1,079 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Rectal Neoplasms

NCT00339469 2019-12-16

Effect of High-Legume Diet on Colorectal Cancer Risk

65 enrolled

Adenoma, Colonic Neoplasms, Inflammation, Insulin Resistance, Colorectal Neoplasms

NCT01517152 2019-12-16

Testing a Spanish Version of a Patient Toxicity Questionnaire

BreastGastrointestinalLymphoidPlasma cellThoracic

112 enrolled

Breast Neoplasms, Colonic Neoplasms, Lung Neoplasms, Lymphoma, Neoplasms, Plasma Cell

NCT01802320 2019-09-20

Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery

18 enrolled 7 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00397878 2019-08-20

AZD0530 (NSC 735464) in Treating Patients With Previously Treated Metastatic Colon Cancer or Rectal Cancer

Phase 2 Terminated

10 enrolled 7 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00096278 2019-07-30

Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer

Phase 3 Completed

2,710 enrolled 8 charts

Colonic Neoplasms

NCT01547845 2019-05-28

Cancer Symptom Data From Multiple Treatment Centers

2,517 enrolled

Phase EARLY_PHASE1 Terminated

Breast Neoplasms, Colonic Neoplasms

NCT01445054 2019-03-11

111 Indium CHX-A DTPA Trastuzumab (Indium-Herceptin) for Imaging Breast Cancer

13 enrolled

Breast Neoplasms, Colonic Neoplasms, Lung Neoplasms, Prostatic Neoplasms

NCT00923520 2018-12-05

A Phase 1, Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Intravenous Dimethane Sulfonate (DMS612) in Advanced Malignancies