Clinical Trials

Phase 2 Active not recruiting

Colonic Neoplasms

NCT02465060 2026-05-26

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

6,452 enrolled 1 FDA

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellThoracic

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Glioma, Carcinoma, Hepatocellular, Lung Neoplasms, Lymphoma, Melanoma, Multiple Myeloma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT03190941 2026-05-22

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Phase 1/2 Recruiting

110 enrolled

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT03745326 2026-05-19

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

Phase 1/2 Terminated

5 enrolled 14 charts

Phase 1 Active not recruiting

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT04704661 2026-05-13

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

51 enrolled

BreastGastrointestinalGynecologicHead & NeckSarcoma

Breast Neoplasms, Carcinosarcoma, Colonic Neoplasms, Neoplasm Metastasis, Salivary Gland Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT02912559 2026-05-05

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

Phase 3 Active not recruiting

712 enrolled 14 charts

Phase NA Active not recruiting

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Repair-Deficiency Disorders

NCT01696981 2026-04-30

Screening for Colorectal Cancer in Older Patients (PLCO Screening Trial)

154,900 enrolled 15 charts

Phase 2 Active not recruiting

Colonic Neoplasms, Rectal Neoplasms

NCT05308446 2026-04-21

Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation

84 enrolled

Phase 1 Active not recruiting

Colonic Neoplasms, Rectal Neoplasms

NCT02381561 2026-04-13

Ropidoxuridine in Treating Patients With Advanced Gastrointestinal Cancer Undergoing Radiation Therapy

19 enrolled

Phase 1/2 Active not recruiting

Colonic Neoplasms, Esophageal Neoplasms, Liver Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT04708470 2026-04-06

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

55 enrolled

GastrointestinalGenitourinaryGynecologicHead & Neck

Anus Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT06885697 2026-02-17

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

Phase 1 Recruiting

100 enrolled

GastrointestinalGynecologicOther solid neoplasmThoracic

Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thymoma, Thymus Neoplasms

NCT00002968 2025-12-29

Edrecolomab in Treating Patients With Stage II Colon Cancer

2,100 enrolled

Colonic Neoplasms

NCT01851369 2024-05-08

TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas

Phase 1/2 Completed

93 enrolled 27 charts

GastrointestinalLymphoid

Colonic Neoplasms, Lymphoma

NCT00019006 2024-03-04

Vaccine Therapy in Treating Patients With Colon, Pancreatic, or Lung Cancer

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Genetic Diseases, Inborn, Small Cell Lung Carcinoma

NCT00020267 2024-03-04

Vaccine Therapy in Treating Patients With Metastatic Cancer

BreastDermatologicGastrointestinalSarcomaThoracic

Uveal Melanoma, Bone Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Eye Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Rectal Neoplasms, Recurrence, Sarcoma, Osteosarcoma, Skin Neoplasms, Colorectal Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Breast Neoplasms, Male, Muscle Neoplasms, Genetic Diseases, Inborn, Histiocytoma, Malignant Fibrous

NCT00407654 2024-03-04

VEGF Trap in Treating Patients With Previously Treated Metastatic Colorectal Cancer

75 enrolled 15 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00019760 2023-10-31

Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver

Colonic Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Genetic Diseases, Inborn

NCT03592641 2023-10-17

Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer

5 enrolled 8 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03801915 2023-03-21

Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers

10 enrolled 14 charts

Colonic Neoplasms, Pancreatic Neoplasms, Cholangiocarcinoma

NCT03384316 2020-09-09

Multi-Targeted Recombinant Ad5 (CEA/MUC1/Brachyury) Based Immunotherapy Vaccine Regimen in People With Advanced Cancer

BreastGastrointestinalGenitourinaryThoracic

11 enrolled 18 charts

Adenoviridae Infections, Breast Neoplasms, Colonic Neoplasms, Lung Neoplasms, Neoplasms, Prostatic Neoplasms

NCT03480152 2020-06-02

Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by the Autologous Cancer

Phase 1/2 Terminated

5 enrolled 11 charts

DermatologicGastrointestinal

Colonic Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Melanoma, Neoplasm Metastasis, Urogenital Neoplasms

NCT00079274 2020-05-13

Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon Cancer

3,397 enrolled 24 charts

Colonic Neoplasms

NCT01254617 2020-03-13

ADCC

GastrointestinalHead & Neck

24 enrolled

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Colonic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms

NCT01287130 2019-12-17

AZD6244 With Cetuximab for Solid Tumors and Colorectal Cancer

10 enrolled

Phase EARLY_PHASE1 Completed

Colonic Neoplasms, Colorectal Neoplasms

NCT00339469 2019-12-16

Effect of High-Legume Diet on Colorectal Cancer Risk

65 enrolled

Adenoma, Colonic Neoplasms, Inflammation, Insulin Resistance, Colorectal Neoplasms

NCT01802320 2019-09-20

Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery

18 enrolled 7 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00397878 2019-08-20

AZD0530 (NSC 735464) in Treating Patients With Previously Treated Metastatic Colon Cancer or Rectal Cancer

10 enrolled 7 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00096278 2019-07-30

Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer

2,710 enrolled 8 charts

Phase EARLY_PHASE1 Terminated

Colonic Neoplasms

NCT01445054 2019-03-11

111 Indium CHX-A DTPA Trastuzumab (Indium-Herceptin) for Imaging Breast Cancer

13 enrolled

BreastGastrointestinalGenitourinaryThoracic

Breast Neoplasms, Colonic Neoplasms, Lung Neoplasms, Prostatic Neoplasms

NCT00923520 2018-12-05

A Phase 1, Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Intravenous Dimethane Sulfonate (DMS612) in Advanced Malignancies

BreastGastrointestinalGenitourinaryLymphoidThoracic

60 enrolled

Breast Neoplasms, Carcinoma, Renal Cell, Colonic Neoplasms, Kidney Neoplasms, Lung Diseases, Lung Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, Neoplasms

NCT01519817 2018-01-29

Cancer Vaccine Targeting Brachyury Protein in Tumors

34 enrolled 19 charts

Adenocarcinoma, Colonic Neoplasms, Neoplasms

NCT00326495 2017-07-24

BAY 43-9006 Plus Cetuximab to Treat Colorectal Cancer

51 enrolled 11 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00081848 2017-07-02

Vaccine Therapy and Radiation to Liver Metastasis in Patients With CEA-Positive Solid Tumors

12 enrolled

GastrointestinalGynecologic

Colonic Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasms

NCT01095523 2017-07-02

Prospective Randomized Trial Evaluating Mandatory Second Look Surgery With HIPEC and CRS vs. Standard of Care in Subjects at High Risk of Developing Colorectal Peritoneal Metastases

Phase 2 Withdrawn

Colonic Neoplasms, Neoplasm Metastasis, Peritoneal Neoplasms, Rectal Neoplasms, Recurrence, Colorectal Neoplasms

NCT01176500 2017-07-02

A Pilot, Open-label Study of 18F-Fluciclatide PET/CT Imaging in the Evaluation of Anti-angiogenic Therapy in Solid Tumors

Phase 1/2 Withdrawn

GastrointestinalGenitourinaryGynecologicThoracic

Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Lung Neoplasms, Uterine Neoplasms

NCT01386502 2017-07-02

CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors

Phase 1 Withdrawn

BreastGastrointestinalGynecologicSarcoma

Breast Neoplasms, Colonic Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma

NCT00468910 2017-05-31

Aspirin in Preventing Colorectal Cancer in Patients at Increased Risk of Colorectal Cancer

GastrointestinalOther neoplasm

79 enrolled 12 charts

Colonic Neoplasms, Precancerous Conditions, Rectal Neoplasms

NCT01383343 2017-04-19

Sorafenib Tosylate, Bevacizumab, Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer

17 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT01270438 2017-04-04

Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients With Metastatic Colorectal Cancer

Phase 2 Withdrawn

Colonic Neoplasms, Rectal Neoplasms

NCT00335504 2017-02-15

Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia

GastrointestinalOther neoplasm

85 enrolled 10 charts

Colonic Neoplasms, Precancerous Conditions, Rectal Neoplasms

NCT01170299 2016-11-01

Low-Fiber Diet or High-Fiber Diet in Preventing Bowel Side Effects in Patients Undergoing Radiation Therapy for Gynecological Cancer, Bladder Cancer, Colorectal Cancer, or Anal Cancer

Phase NA Completed

177 enrolled

GastrointestinalGenitourinaryGynecologicSarcoma

Carcinoma, Ovarian Epithelial, Anus Neoplasms, Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Fallopian Tube Neoplasms, Ovarian Neoplasms, Radiation Injuries, Rectal Neoplasms, Sarcoma, Colorectal Neoplasms

NCT01111292 2016-07-12

Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia

Phase 1/2 Terminated

5 enrolled 7 charts

Colonic Neoplasms, Rectal Neoplasms

NCT01339000 2016-06-22

Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had Chemotherapy

BreastGastrointestinalGenitourinary

1 enrolled 5 charts

Urinary Bladder Neoplasms, Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms

NCT00000611 2016-04-15

Women's Health Initiative (WHI)

BreastGastrointestinal

Bone Diseases, Breast Neoplasms, Cardiovascular Diseases, Colonic Neoplasms, Coronary Disease, Heart Diseases, Osteoporosis, Myocardial Ischemia

NCT00004547 2015-11-18

Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin and Chemotherapy

GastrointestinalGynecologicOther solid neoplasmThoracic

188 enrolled 11 charts

Abdominal Neoplasms, Colonic Neoplasms, Mesothelioma, Peritoneal Neoplasms

NCT00019747 2015-10-28

Surgery With or Without Thalidomide in Treating Patients With Recurrent or Metastatic Colorectal Cancer

39 enrolled 9 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00397384 2015-09-30

Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer

CNSGastrointestinalHead & NeckSarcomaThoracic

43 enrolled

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Pancreatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Stomach Neoplasms, Tongue Neoplasms, Esthesioneuroblastoma, Olfactory, Gastrointestinal Stromal Tumors

NCT00100841 2015-07-27

Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer

66 enrolled 7 charts

Colonic Neoplasms, Rectal Neoplasms

NCT01198535 2015-05-18

Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer

Phase 1 Terminated

60 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT00019435 2015-04-29

LMB-9 Immunotoxin in Treating Patients With Advanced Solid Tumors