Clinical Trials Browser

Phase 3 × Colorectal Neoplasms, Hereditary Nonpolyposis × Clear all

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT02912559 2026-05-05

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

Phase 3 Active not recruiting

712 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Repair-Deficiency Disorders

NCT02000089 2025-10-09

CAPS5

Phase 3 Recruiting

9,000 enrolled

BreastGastrointestinal

Hereditary pancreatitis, Breast Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Dysplastic Nevus Syndrome, Hereditary Sensory and Autonomic Neuropathies, Pancreatic Neoplasms, Peutz-Jeghers Syndrome

NCT02813824 2025-07-08

AAS-Lynch

Phase 3 Active not recruiting

852 enrolled

Gastrointestinal

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT04711434 2021-01-20

PD-1 Antibody for The Prevention of Adenomatous Polyps and Second Primary Tumors in Lynch Syndrome Patients

Phase 3 Unknown

260 enrolled

Gastrointestinal

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT00566644 2013-07-10

Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome

Phase 3 Terminated

600 enrolled

GastrointestinalGynecologic

Colorectal Neoplasms, Hereditary Nonpolyposis, Endometrial Neoplasms

Clinical Trials

PROTECT-Lynch

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

CAPS5

AAS-Lynch

PD-1 Antibody for The Prevention of Adenomatous Polyps and Second Primary Tumors in Lynch Syndrome Patients

Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome