Clinical Trials

Phase 3 Active not recruiting

384 enrolled

BreastGastrointestinal

Breast Cancer, Familial, Colorectal Neoplasms, Hereditary Nonpolyposis

NCT02912559 2026-04-14

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

712 enrolled 14 charts

Phase 1 Active not recruiting

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Repair-Deficiency Disorders

NCT02359565 2026-04-13

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

71 enrolled

CNSGastrointestinal

Familial ependymoma, Turcot syndrome, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Ependymoma, Glioma, Medulloblastoma

NCT05419011 2026-04-13

Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome

Phase 2 Active not recruiting

186 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT05692596 2026-04-01

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

317 enrolled

Ataxia Telangiectasia, Colorectal Neoplasms, Hereditary Nonpolyposis, Dysplastic Nevus Syndrome, Pancreatic Cyst, Peutz-Jeghers Syndrome, Pancreatitis, Chronic

NCT02194387 2026-03-09

Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members

BreastGastrointestinalGynecologicLymphoidOther hematologic neoplasm

337 enrolled

Breast Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Fatigue, Ovarian Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Overweight

NCT05677048 2026-03-09

Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention

BreastGastrointestinalGynecologic

205 enrolled

Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Ovarian Neoplasms, Pancreatic Neoplasms, Uterine Neoplasms, Endometrial Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT05078866 2026-03-03

Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients

Phase 1/2 Active not recruiting

45 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT02371135 2026-02-05

Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes

77 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT04261972 2026-01-14

CHARM1

BreastGastrointestinalGynecologic

1,416 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplasms, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT00582296 2026-01-07

Multi-Organ Screening Recommendations in Patients With Lynch Syndrome

1,530 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT00261456 2025-09-26

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

GastrointestinalGenitourinary

3,500 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Prostatic Neoplasms, Genetic Predisposition to Disease

NCT02813824 2025-07-08

AAS-Lynch

Phase 3 Active not recruiting

852 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT04197856 2024-07-09

DIRECT

BreastGastrointestinalGynecologic

490 enrolled

Breast Cancer, Familial, Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Breast and Ovarian Cancer Syndrome

NCT02206360 2024-05-24

PCEDP

100 enrolled