Clinical Trials

GastrointestinalGynecologic

25 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Endometrial Neoplasms

NCT02775461 2026-02-11

Pancreas Registry and High Risk Registry

DermatologicGastrointestinal

1,368 enrolled

Melanoma, Cutaneous Malignant, Colorectal Neoplasms, Hereditary Nonpolyposis, Pancreatic Cyst, Pancreatic Neoplasms, Pancreatitis, Peutz-Jeghers Syndrome, Pancreatitis, Chronic

NCT03050268 2026-02-09

SJFAMILY

BreastCNSClassical hematologyDermatologicEndocrineGastrointestinalGynecologicLymphoidOther solid neoplasmSarcoma

1,500 enrolled

Turcot syndrome, Juvenile polyposis syndrome, Choroid Plexus Carcinoma, GATA2 Deficiency, Basal Cell Nevus Syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Fanconi Anemia, Hamartoma Syndrome, Multiple, von Hippel-Lindau Disease, Hodgkin Disease, Lymphoma, Non-Hodgkin, Melanoma, Neuroblastoma, Neurofibromatosis 1, Noonan Syndrome, Pancreatic Neoplasms, Paraganglioma, Peutz-Jeghers Syndrome, Pheochromocytoma, Rothmund-Thomson Syndrome, Adenomatous Polyposis Coli, Retinoblastoma, Rhabdomyosarcoma, Tuberous Sclerosis, Neurofibromatosis 2, Li-Fraumeni Syndrome, Adrenocortical Carcinoma, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2a, Dyskeratosis Congenita, Genetic Predisposition to Disease, Anemia, Diamond-Blackfan, Carney Complex, Hereditary Breast and Ovarian Cancer Syndrome

NCT04494945 2026-01-23

Identifying and Caring for Individuals With Inherited Cancer Syndrome

BreastGastrointestinalGynecologic

27,500 enrolled

Carcinoma, Intraductal, Noninfiltrating, Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT02012699 2026-01-22

iCaRe2

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther hematologic neoplasmOther solid neoplasmPlasma cellSarcomaThoracic

999,999 enrolled

Anus Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Duodenal Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Lip Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Mesothelioma, Mouth Neoplasms, Multiple Myeloma, Nasopharyngeal Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Paranasal Sinus Neoplasms, Paraproteinemias, Penile Neoplasms, Peritoneal Neoplasms, Adenomatous Polyposis Coli, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Sarcoma, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Ureteral Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Central Nervous System Neoplasms, Thyroid Nodule, Endometrial Neoplasms, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT03805919 2026-01-08

Men at High Genetic Risk for Prostate Cancer

500 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Prostatic Neoplasms

NCT07077447 2025-12-22

EuroCUT

2,500 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT06726642 2025-12-16

CHARM2

BreastGastrointestinalGynecologic

1,000 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Stomach Neoplasms, Li-Fraumeni Syndrome, Hereditary Breast and Ovarian Cancer Syndrome

NCT07219537 2025-12-16

A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

30 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Crohn Disease, Inflammatory Bowel Diseases

NCT03702309 2025-11-26

LIBERATE

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellThoracic

2,500 enrolled

Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Hamartoma Syndrome, Multiple, Head and Neck Neoplasms, Kidney Neoplasms, Leukemia, Lung Neoplasms, Lymphoma, Melanoma, Meningioma, Neoplasms, Ovarian Neoplasms, Uterine Neoplasms, Neoplasms, Plasma Cell

NCT06218433 2025-11-18

Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)

200 enrolled

Urogenital Diseases, Urinary Bladder Neoplasms, Carcinoma, Transitional Cell, Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary

NCT05411718 2025-11-13

A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

Phase 2 Recruiting

40 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT02000089 2025-10-09

CAPS5

Phase 3 Recruiting

9,000 enrolled

BreastGastrointestinal

Hereditary pancreatitis, Breast Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Dysplastic Nevus Syndrome, Hereditary Sensory and Autonomic Neuropathies, Pancreatic Neoplasms, Peutz-Jeghers Syndrome

NCT02705846 2025-09-26

GENPROS

4,260 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Prostatic Neoplasms

NCT07194551 2025-09-26

Lynch-SCAN

GastrointestinalGynecologic

30 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Endometrial Neoplasms

NCT05963191 2025-09-03

CADLYNCH

272 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT05410977 2025-08-17

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

750 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT06989814 2025-08-11

SMART

50 enrolled

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT03124212 2025-02-14

CASCADE

BreastGastrointestinalGynecologic

700 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Breast and Ovarian Cancer Syndrome

NCT06582914 2025-01-15

LINEAGE

5,000 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT04920149 2024-12-17

MesaCAPP

Phase 2 Recruiting

150 enrolled

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis

NCT06712095 2024-12-05

PILLCAM

25 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Hamartoma Syndrome, Multiple, Li-Fraumeni Syndrome

NCT06708429 2024-12-02

LYNX-EYE

GastrointestinalGynecologic

300 enrolled

Turcot syndrome, Lynch syndrome I (site-specific colonic cancer), Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Colorectal Neoplasms, Endometrial Neoplasms, Lynch Syndrome II

NCT05704010 2024-11-27

Videocapsule Endoscopy in Lynch Syndrome

100 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Lynch Syndrome II

NCT05129605 2024-10-09

PROGRESS

400 enrolled

Turcot syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Prostatic Neoplasms, Genetic Predisposition to Disease

NCT06523582 2024-07-26

Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients

CNSEndocrineGastrointestinalHead & NeckNETSarcoma

750 enrolled

Carney-Stratakis Syndrome, Carney Triad, Pituitary Adenoma, Familial Isolated, Colorectal Neoplasms, Hereditary Nonpolyposis, Hamartoma Syndrome, Multiple, von Hippel-Lindau Disease, Adenoma, Islet Cell, Neurofibromatosis 1, Paraganglioma, Pheochromocytoma, Pituitary Neoplasms, Tuberous Sclerosis, Li-Fraumeni Syndrome, Carcinoma, Medullary, Neuroendocrine Tumors, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2a, Gastrointestinal Stromal Tumors, Hyperparathyroidism, Primary, Carney Complex

NCT06447961 2024-06-21

PSYLIVED

66 enrolled

Polyposis Syndrome, Hereditary Mixed, 1, Polyposis Syndrome, Hereditary Mixed, 2, Colorectal Neoplasms, Hereditary Nonpolyposis

NCT04095195 2023-01-13

IRFARPC

1,000 enrolled