Clinical Trials

Neoplasm Metastasis, Colorectal Neoplasms

NCT07222800 2026-04-08

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

800 enrolled

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasm Metastasis, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT05673148 2026-04-07

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study

364 enrolled

Colorectal Neoplasms

NCT07044362 2026-03-19

Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis

Phase NA Recruiting

100 enrolled

Phase 1/2 Active not recruiting

Liver Neoplasms, Colorectal Neoplasms

NCT04868877 2026-02-19

Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination

194 enrolled

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Head and Neck Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT02738606 2026-02-17

Liver Surgery and Chemotherapy in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by Surgery and Lung Metastases That Cannot Be Removed by Surgery

Phase 2 Terminated

29 enrolled 8 charts

Colorectal Neoplasms

NCT05731947 2026-01-29

Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors

Phase 1/2 Completed

42 enrolled

Phase 2 Active not recruiting

Colorectal Neoplasms

NCT03599752 2026-01-09

Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases

Colorectal Neoplasms

NCT07079462 2025-12-24

Comparing 68Ga-FAPI PET-Guided Abdominal Radiotherapy Combined With Second-Line Standard Therapy and Cadonilimab Versus Second-Line Standard Therapy in Colorectal Cancer With Peritoneal Metastasis

Phase 2 Recruiting

Phase 3 Not yet recruiting

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT07284394 2025-12-16

PACHA-02

272 enrolled

Phase 2 Not yet recruiting

Colorectal Neoplasms

NCT07134101 2025-08-29

SMARTi-RC01

138 enrolled

CNSDermatologicGastrointestinalGynecologicHead & NeckLymphoidThoracic

Disease, Colorectal Neoplasms

NCT02327078 2025-08-14

A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers (ECHO-204)

Phase 1/2 Completed

307 enrolled 27 charts

Glioblastoma, Head and Neck Neoplasms, Lung Neoplasms, Lymphoma, Melanoma, Ovarian Neoplasms, Colorectal Neoplasms

NCT05755672 2025-07-17

On-CALL

Recruiting

100 enrolled

Phase 1 Active not recruiting

Colorectal Neoplasms

NCT05704985 2025-05-29

Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors

39 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Kidney Neoplasms, Neoplasms, Pancreatic Neoplasms, Skin Neoplasms, Colorectal Neoplasms

NCT06794086 2025-05-13

SPARKLE-L

24 enrolled

Phase 1 Not yet recruiting

Colorectal Neoplasms

NCT04062721 2025-04-06

LICoRN-01

12 enrolled

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidMyeloidNETOther hematologic neoplasmOther solid neoplasmPlasma cellSarcomaThoracic

Colorectal Neoplasms

NCT04028479 2024-12-18

ROOT

Completed

167 enrolled

Nasopharyngeal Carcinoma, Adenocarcinoma, Adrenal Gland Neoplasms, Anus Neoplasms, Appendiceal Neoplasms, Astrocytoma, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoid Tumor, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Chondrosarcoma, Colonic Neoplasms, Carcinoma, Adenoid Cystic, Esophageal Neoplasms, Fallopian Tube Neoplasms, Glioblastoma, Head and Neck Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Liposarcoma, Liver Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Melanoma, Mesothelioma, Multiple Myeloma, Neoplasms, Multiple Endocrine Neoplasia, Neoplasms, Unknown Primary, Ovarian Neoplasms, Pancreatic Neoplasms, Parathyroid Neoplasms, Parotid Neoplasms, Penile Neoplasms, Pharyngeal Neoplasms, Pheochromocytoma, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Kaposi, Osteosarcoma, Skin Neoplasms, Stomach Neoplasms, Sarcoma, Synovial, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Tongue Neoplasms, Ureteral Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Colorectal Neoplasms, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Central Nervous System Neoplasms, Cholangiocarcinoma, Carcinoma, Small Cell, Neuroendocrine Tumors, Brain Stem Neoplasms, Gestational Trophoblastic Disease, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT06566755 2024-08-22

Cadonilimab (AK104) Combined With Chemotherapy and Bevacizumab as First-line Treatment for RAS Mutated or Right Sided-metastatic MSS Colorectal Cancer

30 enrolled

Phase 2 Not yet recruiting

Colorectal Neoplasms

NCT06513221 2024-07-22

A Prospective Study of MSS-type Metastatic Colorectal Cancer Receiving Multiple Lines of Standard Chemotherapy, Bevacizumab Combined With Adebrelimab

100 enrolled

Colorectal Neoplasms

NCT06449937 2024-06-10

Local Liver Treatment for Multi-organ Colorectal Cancer Metastases

Phase NA Recruiting

130 enrolled

BreastGastrointestinalThoracic

Colorectal Neoplasms

NCT04638751 2024-04-05

ARGONAUT: Stool and Blood Sample Bank for Cancer Patients

Recruiting

5,000 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT03329950 2024-03-28

A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies

Phase 1 Completed

132 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidThoracic

Bile Duct Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Esophageal Neoplasms, Fallopian Tube Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Mouth Neoplasms, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Lymphoma, Large B-Cell, Diffuse, Cholangiocarcinoma, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Hyper-IgM Immunodeficiency Syndrome

NCT03494946 2024-02-06

SECAIII

Phase NA Recruiting

30 enrolled

Colorectal Neoplasms

NCT01515787 2024-02-02

PROSPECT: Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer Undergoing Surgery

Phase 2/3 Unknown

1,194 enrolled 25 charts

Rectal Neoplasms, Colorectal Neoplasms

NCT03135652 2024-01-03

Consolidative Radiotherapy for Colorectal Cancer Liver Metastases Receiving Surgery or Radiofrequency Ablation

Phase 2 Withdrawn

Colorectal Neoplasms

NCT03193814 2024-01-03

XHZL

Phase 2 Withdrawn

Colorectal Neoplasms

NCT06177288 2023-12-20

DEBIRI

Phase NA Unknown

39 enrolled

Colorectal Neoplasms

NCT06120127 2023-11-07

IMPROVE

Phase 2 Unknown

80 enrolled

Colorectal Neoplasms

NCT04653480 2023-07-17

Surufatinib, Toripalimab and Chemotherapy in Second-line MT and MSS CRC

Phase 2 Unknown

61 enrolled

Colorectal Neoplasms

NCT02969681 2023-06-27

Vitality

Phase 3 Completed

442 enrolled

Colorectal Neoplasms

NCT03803436 2023-03-16

COLT

Phase 2 Unknown

22 enrolled

Liver Neoplasms, Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT04021589 2023-01-30

Chemotherapy w/wo WeiLeShu in Metastatic Colorectal Cancer

Phase 2 Completed

Communicable Diseases, Colorectal Neoplasms

NCT01732783 2022-11-08

Observational Study of Vectibix With Chemotherapy for Metastatic Colorectal Cancer Patients

Completed

213 enrolled 30 charts

Colorectal Neoplasms

NCT05540951 2022-09-15

VIC Regimen Versus Bevacizumab Plus Chemotherapy as First-Line Treatment for BRAF V600E-Mutated Advanced Colorectal Cancer

Phase 3 Unknown

78 enrolled

Colorectal Neoplasms

NCT01307878 2022-06-14

New Adjuvant Chemotherapy of Asymptomatic Resectable Primary Lesion With Unresectable Liver-limited Metastases

Phase 3 Completed

320 enrolled

Liver Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT05409417 2022-06-08

Exploratory Study on Combined Conversion Immunotherapy for Liver Metastasis of MSS Type Initial Unresectable Colorectal Cancer Based on Gene Status

Phase 2/3 Unknown

Colorectal Neoplasms

NCT05322486 2022-04-11

Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases

Unknown

200 enrolled