Clinical Trials Browser

Phase 2 × Colorectal Neoplasms × Leucovorin × Clear all

NCT00492999 2026-06-03

Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Phase 2 Active not recruiting

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT06820463 2026-06-02

AndroMETa-CRC

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT07621497 2026-06-02

FOLFOX8 Versus mFOLFOX6 With Bevacizumab or Cetuximab for First-Line Unresectable Metastatic Colorectal Cancer (Phase II)

Phase 2 Not yet recruiting

Gastrointestinal

Colorectal Neoplasms

NCT06948448 2026-05-18

A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT06792695 2026-05-11

CANTOR

Phase 2 Recruiting

Gastrointestinal

Neoplasm Metastasis, Colorectal Neoplasms

NCT07562711 2026-05-01

CLEAR-02

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05004350 2026-04-30

NAUTICALCRC

Phase 2 Completed

107 enrolled 69 charts

Gastrointestinal

Colorectal Neoplasms

NCT07559760 2026-04-30

New Second-Line Combo Therapy for MSS Metastatic Colorectal Cancer

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT04245865 2026-04-03

Toco-CoR

Phase 2 Active not recruiting

Gastrointestinal

Colorectal Neoplasms

NCT07011576 2026-03-18

FRUITFUL

Phase 2 Recruiting

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07474727 2026-03-16

A Phase II Study of AMT-676 Combination Therapies in Advanced Colorectal Cancer

Phase 2 Not yet recruiting

Gastrointestinal

Colorectal Neoplasms

NCT04430738 2026-02-24

Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers

Phase 2 Active not recruiting

40 enrolled 67 charts

Gastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Gallbladder Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT06501989 2026-02-11

Study of 5-fluorouracil (5-FU) in Patients With Metastatic Colorectal Cancer

Phase 2 Withdrawn

Gastrointestinal

Colorectal Neoplasms

NCT00556413 2026-02-05

Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01815359 2026-02-05

ICARuS

Phase 2 Active not recruiting

Gastrointestinal

Appendiceal Neoplasms, Colorectal Neoplasms

NCT06268015 2026-02-05

BBOpCo

Phase 2 Active not recruiting

Gastrointestinal

Neoplasm Metastasis, Colorectal Neoplasms

NCT00335816 2026-01-14

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT05959356 2025-12-17

CEIL

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05843188 2025-12-09

Study of Hydroxychloroquine With FOLFIRI and Bevacizumab in DTP-high Metastatic Colorectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05382442 2025-10-14

A Study of AK112 With or Without AK117 in Metastatic Colorectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Colorectal Neoplasms

NCT04595266 2025-09-29

LIVERPEARL

Phase 2 Active not recruiting

Gastrointestinal

Colorectal Neoplasms

NCT03929666 2025-09-12

A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Biliary Tract Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT05678257 2025-09-12

A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer

Phase 2 Terminated

180 enrolled 16 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT07150403 2025-09-08

Second-line Doublet Chemotherapy (FOLFOX or FOLFIRI) Plus Fruquintinib Versus Doublet Chemotherapy (FOLFOX or FOLFIRI) Plus Bevacizumab in Metastatic Colorectal Cancer

Phase 2 Not yet recruiting

Gastrointestinal

Colorectal Neoplasms

NCT00766142 2025-08-29

COCHISE

Phase 2 Terminated

18 enrolled 9 charts

GastrointestinalGynecologic

Colonic Neoplasms, Peritoneal Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03493048 2025-08-03

Cetuximab Plus FOLFOXIRI vs Cetuximab Plus FOLFOX For CRCLM

Phase 2 Active not recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05571644 2025-07-23

OPTICAL-2

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05330429 2025-07-01

ELEVATE CRC

Phase 2 Terminated

77 enrolled 22 charts

Gastrointestinal

Colorectal Neoplasms

NCT03401294 2025-05-09

CONVERSION

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT04072198 2025-03-13

NIVACOR

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT02980510 2025-02-20

PANIRINOX

Phase 2 Active not recruiting

Gastrointestinal

Colorectal Neoplasms

NCT01652196 2025-02-05

Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer

Phase 2 Completed

56 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03117972 2025-02-05

CLavSyn

Phase 2 Terminated

Gastrointestinal

Colorectal Neoplasms

NCT04513951 2025-01-09

AVETRIC

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT06184698 2024-10-09

Liposomal Irinotecan and Leucovorin/5-fluorouracil Plus Bevacizumab in Metastatic Colorectal Cancer

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT06493760 2024-09-19

A Phase 2 Study of SSGJ-707 in Metastatic Colorectal Cancer Patients

Phase 2 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT02705300 2024-08-29

Side Effects to FOLFOXIRI + Tocotrienol/Placebo as First Line Treatment of Metastatic Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT02842580 2024-07-10

HIGH-LIGHT

Phase 2 Terminated

21 enrolled 12 charts

Gastrointestinal

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT00321828 2024-03-21

Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colon Cancer That Cannot Be Removed By Surgery

Phase 2 Completed

90 enrolled 6 charts

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms

NCT05839470 2023-11-15

Cadonilimab Plus FOLFOXIRI and Bevacizumab as First Line Therapy for Metastatic MSS Colorectal Cancer

Phase 2 Unknown

Gastrointestinal

Colorectal Neoplasms

NCT04034459 2023-11-14

AIO-KRK-0116

Phase 2 Unknown

Gastrointestinal

Colorectal Neoplasms

NCT00019760 2023-10-31

Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Genetic Diseases, Inborn

NCT03721653 2023-10-12

AtezoTRIBE

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT00601198 2023-08-01

A Study of Amifostine (Ethyol) in Patients With Colorectal Cancer

Phase 2 Terminated

4 enrolled 9 charts

Gastrointestinal

Colorectal Neoplasms

NCT00098787 2023-07-05

Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer

Phase 2 Completed

247 enrolled 10 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00004860 2023-06-15

Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01991873 2023-06-15

PanaMa

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT03279289 2023-04-13

AFEMA

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT01628211 2023-03-24

HIPEC

Phase 2 Unknown

Gastrointestinal

Colorectal Neoplasms

NCT05480280 2023-02-28

FIND

Phase 2 Unknown

Gastrointestinal

Colorectal Neoplasms