Announcements Trials
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Phase

Phase 2 4Phase 3 1

Status

Terminated 5Completed 5Unknown 2Withdrawn 1

Sponsor Class

OTHER 4NIH 1

Study Type

Interventional 5

Sponsor

Cancer Type

Gastrointestinal 5Other 1Breast 1

Conditions

Polycystic Ovary Syndrome 91Breast Neoplasms 21Insulin Resistance 18Obesity 14Prostatic Neoplasms 10Pancreatic Neoplasms 8Endometrial Neoplasms 7Neoplasms 6Infertility 6Anovulation 6Neoplasm Metastasis 5Colorectal Neoplasms 5Rectal Neoplasms 4Hyperandrogenism 4Weight Loss 3Squamous Cell Carcinoma of Head and Neck 3Precursor Cell Lymphoblastic Leukemia-Lymphoma 3Lung Neoplasms 3Leukemia, Lymphocytic, Chronic, B-Cell 3Hyperinsulinism 3Head and Neck Neoplasms 3Diabetes Mellitus, Type 2 3Diabetes Mellitus 3Carcinoma, Non-Small-Cell Lung 3Uterine Cervical Neoplasms 2Recurrence 2Rare Diseases 2Premature Birth 2Overweight 2Ovarian Neoplasms 2

Interventions

Fluorouracil 255Leucovorin 224Oxaliplatin 218Irinotecan 206Bevacizumab 200Capecitabine 144Cetuximab 136Panitumumab 68Folfox protocol 63regorafenib 50Colonoscopy 44pembrolizumab 42IFL protocol 39Radiotherapy 32Nivolumab 31Drug Therapy 27trifluridine tipiracil drug combination 26Gemcitabine 24Blood Specimen Collection 23Chemotherapy, Adjuvant 20Surveys and Questionnaires 19Celecoxib 19Surgical Procedures, Operative 16durvalumab 15Neoadjuvant Therapy 15Cyclophosphamide 14Cisplatin 14aflibercept 13Standard of Care 13Pemetrexed 13

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Completed × Colorectal Neoplasms × Metformin × Clear all
NCT03800602 2024-09-05

Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer

Emory University

Phase 2 Completed
29 enrolled 7 charts
Gastrointestinal

Colorectal Neoplasms

NCT05921942 2024-02-02

The Impact of Metformin Administration on the Clinical Outcome of Stage IV Colon Cancer

Ain Shams University

Phase 3 Completed
70 enrolled
Gastrointestinal

Colorectal Neoplasms

NCT01312467 2019-03-05

Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI

National Cancer Institute (NCI)

Phase 2 Completed
45 enrolled 7 charts
GastrointestinalOther

Obesity, Colorectal Neoplasms, Adenomatous Polyps

NCT01340300 2018-06-06

Exercise and Metformin in Colorectal and Breast Cancer Survivors

Dana-Farber Cancer Institute

Phase 2 Completed
139 enrolled 18 charts
BreastGastrointestinal

Breast Neoplasms, Insulin Resistance, Motor Activity, Colorectal Neoplasms

NCT01941953 2015-04-08

Metformin and 5-fluorouracil for Refractory Colorectal Cancer.

Instituto do Cancer do Estado de São Paulo

Phase 2 Completed
50 enrolled
Gastrointestinal

Colorectal Neoplasms

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