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Phase

Phase EARLY_PHASE1 1Phase 1/2 1

Status

Completed 1Active not recruiting 1

Sponsor Class

OTHER 2NETWORK 1

Study Type

Interventional 2

Sponsor

Cancer Type

Sarcoma 2

Conditions

Colorectal Neoplasms 240Rectal Neoplasms 93Colonic Neoplasms 91Pancreatic Neoplasms 87Stomach Neoplasms 68Neoplasm Metastasis 47Esophageal Neoplasms 41Neoplasms 36Small Cell Lung Carcinoma 29Lung Neoplasms 29Neuroblastoma 28Glioblastoma 28Glioma 27Brain Neoplasms 26Carcinoma, Non-Small-Cell Lung 22Adenocarcinoma Of Esophagus 20Gliosarcoma 19Breast Neoplasms 18Astrocytoma 18Esophageal Squamous Cell Carcinoma 17Central Nervous System Neoplasms 17Unspecified Adult Solid Tumor, Protocol Specific 16Oligodendroglioma 13Adenocarcinoma 13Rhabdomyosarcoma 10Gastrointestinal Neoplasms 10Biliary Tract Neoplasms 10Sarcoma 9Gallbladder Neoplasms 9Cholangiocarcinoma 9

Interventions

Vincristine 4Etoposide 4Doxorubicin 4Cyclophosphamide 4Thiotepa 3Temozolomide 3Ifosfamide 3Filgrastim 3Cisplatin 3fludarabine phosphate 2Radiotherapy 2Melphalan 2Irinotecan 2Hyperthermic Intraperitoneal Chemotherapy 2Granulocyte Colony-Stimulating Factor 2Cytoreduction Surgical Procedures 2Brachytherapy 2thymoglobulin 1temsirolimus 1sodium thiosulfate 1prexasertib 1pembrolizumab 1pegylated granulocyte colony-stimulating factor 1pegfilgrastim 1pazopanib 1pasireotide 1fludarabine 1Zoledronic Acid 1X-Rays 1Topotecan 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
OTHER × Desmoplastic Small Round Cell Tumor × Irinotecan × Clear all
NCT01189643 2025-09-05

Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell Tumor

Memorial Sloan Kettering Cancer Center

Phase EARLY_PHASE1 Active not recruiting
15 enrolled
Sarcoma

Sarcoma, Desmoplastic Small Round Cell Tumor

NCT04095221 2025-02-20

A Study of the Drugs Prexasertib, Irinotecan, and Temozolomide in People With Desmoplastic Small Round Cell Tumor and Rhabdomyosarcoma

Memorial Sloan Kettering Cancer Center

Phase 1/2 Completed
21 enrolled
Sarcoma

Rhabdomyosarcoma, Desmoplastic Small Round Cell Tumor

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