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Phase

Phase 1/2 1

Status

Completed 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

Sarcoma 1

Conditions

Neoplasms 4Neoplasm Metastasis 3Squamous Cell Carcinoma of Head and Neck 2Ovarian Neoplasms 2Leukemia, Myeloid, Acute 2Colorectal Neoplasms 2Central Nervous System Neoplasms 2Carcinoma, Non-Small-Cell Lung 2Breast Neoplasms 2Solid Tumor 1Small Cell Lung Carcinoma 1Rhabdomyosarcoma 1Prostatic Neoplasms 1Myelodysplastic Syndromes 1Microphthalmia, Isolated, with Coloboma 5 1Medulloblastoma 1Leukemia, Myelomonocytic, Chronic 1Hereditary Breast and Ovarian Cancer Syndrome 1Head and Neck Neoplasms 1Fanconi Anemia 1Endometrial Neoplasms 1Desmoplastic Small Round Cell Tumor 1Carcinoma, Squamous Cell 1Brain Neoplasms 1Anus Neoplasms 1Advanced Cancer 1

Interventions

Cyclophosphamide 10Doxorubicin 9Vincristine 7Etoposide 7Ifosfamide 6Filgrastim 5Radiotherapy 4fludarabine phosphate 3Topotecan 3Thiotepa 3Temozolomide 3Peripheral Blood Stem Cell Transplantation 3Melphalan 3Irinotecan 3Cisplatin 3Carboplatin 3Brachytherapy 3seclidemstat 2Tacrolimus 2PM 01183 2Neoadjuvant Therapy 2Injections 2Hyperthermic Intraperitoneal Chemotherapy 2Granulocyte Colony-Stimulating Factor 2Epirubicin 2Dactinomycin 2Cytoreduction Surgical Procedures 2Cyclosporine 2Chemotherapy, Adjuvant 2thymoglobulin 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Desmoplastic Small Round Cell Tumor × prexasertib × Clear all
NCT04095221 2025-02-20

A Study of the Drugs Prexasertib, Irinotecan, and Temozolomide in People With Desmoplastic Small Round Cell Tumor and Rhabdomyosarcoma

Memorial Sloan Kettering Cancer Center

Phase 1/2 Completed
21 enrolled
Sarcoma

Rhabdomyosarcoma, Desmoplastic Small Round Cell Tumor

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