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Phase

Phase 1 1

Status

Recruiting 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

CNS 1

Conditions

Lymphoma, Non-Hodgkin 4Rhabdoid Tumor 3Pinealoma 3Neuroectodermal Tumors, Primitive 3Neoplasms, Germ Cell and Embryonal 3Multiple Myeloma 3Medulloblastoma 3Glioma 3Ependymoma 3Choroid Plexus Carcinoma 3Central Nervous System Neoplasms 3Brain Neoplasms 3Recurrence 2Lymphoma, Large B-Cell, Diffuse 2Lymphoma, Follicular 2Lymphoma, B-Cell 2Leukemia, Lymphocytic, Chronic, B-Cell 2Stomach Neoplasms 1Precursor Cell Lymphoblastic Leukemia-Lymphoma 1Lymphoma, T-Cell, Peripheral 1Lymphoma, Mantle-Cell 1Lymphoma, Large-Cell, Anaplastic 1Lymphoma, Extranodal NK-T-Cell 1Lymphoma, B-Cell, Marginal Zone 1Immunoblastic Lymphadenopathy 1Gliosarcoma 1Glioblastoma 1Enteropathy-Associated T-Cell Lymphoma 1Diffuse Intrinsic Pontine Glioma 1Dendritic Cell Sarcoma, Interdigitating 1

Interventions

Radiotherapy 6Radiation 3Panobinostat 3Cyclophosphamide 3ribociclib 2Temozolomide 2Specimen Handling 2Magnetic Resonance Spectroscopy 2Everolimus 2Etoposide 2Dasatinib 2vandetanib 1temsirolimus 1spartalizumab 1sargramostim 1reolysin 1pembrolizumab 1ovex 1marizomib 1irinotecan sucrosofate 1gallium maltolate 1etoposide phosphate 1crenolanib 1balstilimab 1adavosertib 1abemaciclib 1X-Rays 1Vorinostat 1Vaccines 1Topotecan 1

Date Range

30 days90 days1 yearAll

Options

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Clinical Trials

1 trials
RecentStart dateEnrollment
Phase 1 × Diffuse Intrinsic Pontine Glioma × Automobiles × Clear all
NCT04185038 2026-04-13

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Seattle Children's Hospital

Phase 1 Recruiting
90 enrolled
CNS

Choroid Plexus Carcinoma, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

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