Clinical Trials

Diffuse Intrinsic Pontine Glioma, Glioma

NCT04943848 2026-03-17

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

36 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT01165333 2026-03-16

CILENT

32 enrolled

Phase 1 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Glioma

NCT04837547 2026-03-09

PEACH

24 enrolled

Phase 1 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Neuroblastoma

NCT07076498 2026-02-25

Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation

20 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT05762419 2026-01-28

FUS Etoposide for DMG

10 enrolled

Phase 1 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Brain Diseases, Brain Neoplasms, Glioma, Nervous System Neoplasms, Central Nervous System Neoplasms

NCT07331064 2026-01-09

GABRIEL

15 enrolled

Phase 1 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Recurrence, Rhabdoid Tumor

NCT05768880 2025-11-20

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

72 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT03396575 2025-10-29

BRAVO

Phase 1 Terminated

11 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Influenza, Human, Xanthomatosis, Cerebrotendinous

NCT04099797 2025-09-04

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

37 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Neoplasms, Germ Cell and Embryonal, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT06624371 2025-07-22

AflacBT2303

Diffuse Intrinsic Pontine Glioma, Glioma, Medulloblastoma

NCT04804709 2025-06-08

Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG)

Phase 1 Terminated

5 enrolled 11 charts

Diffuse Intrinsic Pontine Glioma

NCT04749641 2025-06-06

ENACTING

16 enrolled

Diffuse Intrinsic Pontine Glioma

NCT02420613 2025-04-02

Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma

NCT06221553 2025-03-30

CMD03DIPG

9 enrolled

Diffuse Intrinsic Pontine Glioma

NCT05298995 2025-02-05

GD2-CAR T Cells for Pediatric Brain Tumours

54 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal

NCT05717699 2024-02-28

Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma, Drug-Related Side Effects and Adverse Reactions

NCT05717712 2024-02-28

Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma, Drug-Related Side Effects and Adverse Reactions

NCT04341311 2024-02-15

DIPG

Phase 1 Terminated

4 enrolled

Diffuse Intrinsic Pontine Glioma, Neoplasms, Recurrence

NCT04264143 2023-12-18

CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

9 enrolled

Diffuse Intrinsic Pontine Glioma

NCT02644460 2023-10-26

AflacST1501

53 enrolled

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT02444546 2023-04-24

Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors

6 enrolled