Clinical Trials Browser

Phase 1 × Recruiting × Diffuse Intrinsic Pontine Glioma × Clear all

NCT04185038 2026-04-13

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Choroid Plexus Carcinoma, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT04943848 2026-03-17

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

Phase 1 Recruiting

36 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Glioma

NCT05762419 2026-01-28

FUS Etoposide for DMG

Phase 1 Recruiting

10 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Brain Diseases, Brain Neoplasms, Glioma, Nervous System Neoplasms, Central Nervous System Neoplasms

NCT04099797 2025-09-04

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

Phase 1 Recruiting

37 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Neoplasms, Germ Cell and Embryonal, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT06624371 2025-07-22

AflacBT2303

Phase 1 Recruiting

18 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Glioma, Medulloblastoma

NCT06221553 2025-03-30

CMD03DIPG

Phase 1 Recruiting

9 enrolled

CNS

Diffuse Intrinsic Pontine Glioma

NCT05298995 2025-02-05

GD2-CAR T Cells for Pediatric Brain Tumours

Phase 1 Recruiting

54 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal

NCT05717699 2024-02-28

Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma

Phase 1 Recruiting

18 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Drug-Related Side Effects and Adverse Reactions

NCT05717712 2024-02-28

Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma

Phase 1 Recruiting

18 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Drug-Related Side Effects and Adverse Reactions