Announcements Trials
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Phase

Phase 1 10Phase 2 6Phase 1/2 5Phase EARLY_PHASE1 2Phase 3 1

Status

Recruiting 2Completed 2Withdrawn 1Not yet recruiting 1Active not recruiting 1

Sponsor Class

OTHER 2

Study Type

Interventional 2

Sponsor

Cancer Type

CNS 2

Conditions

Multiple Myeloma 27Breast Neoplasms 23Neoplasms 22Pancreatic Neoplasms 19Prostatic Neoplasms 17Glioma 17Glioblastoma 16Leukemia, Myeloid, Acute 15Recurrence 14Solid Tumor 12Precursor Cell Lymphoblastic Leukemia-Lymphoma 12Lymphoma, Non-Hodgkin 12Brain Neoplasms 10Squamous Cell Carcinoma of Head and Neck 9Lung Neoplasms 9Triple Negative Breast Neoplasms 8Lymphoma 8Hematologic Neoplasms 8Melanoma 7Lymphoma, B-Cell 7Colorectal Neoplasms 7Carcinoma, Non-Small-Cell Lung 7Advanced Solid Tumors 7Polycystic Ovary Syndrome 6Neoplasm Metastasis 6Head and Neck Neoplasms 6Carcinoma, Hepatocellular 6Stomach Neoplasms 5Myelodysplastic Syndromes 5Leukemia, Plasma Cell 5

Interventions

lorlatinib 1larotrectinib 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Phase EARLY_PHASE1 × Recruiting × Diffuse Intrinsic Pontine Glioma × Clear all
NCT04655404 2026-03-18

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

Nationwide Children's Hospital

Phase EARLY_PHASE1 Recruiting
15 enrolled
CNS

Diffuse Intrinsic Pontine Glioma, Glioma

NCT06333899 2026-03-12

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Nationwide Children's Hospital

Phase EARLY_PHASE1 Recruiting
15 enrolled
CNS

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma

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