Clinical Trials

65 enrolled

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Central Nervous System Neoplasms

NCT06465199 2026-04-13

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

289 enrolled

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Neuroblastoma, Sarcoma, Ewing, Osteosarcoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT05096481 2026-04-08

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

120 enrolled

Phase 2 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Glioma, Medulloblastoma

NCT07206849 2026-04-08

Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)

79 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma

NCT07501156 2026-03-30

H3K27M-specific Immune Effector Cells Targeting DMG/DIPG

30 enrolled

Phase 1 Active not recruiting

Diffuse Intrinsic Pontine Glioma

NCT03605550 2026-03-27

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

64 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT06838676 2026-03-27

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

60 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT05843253 2026-03-20

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

120 enrolled

Phase EARLY_PHASE1 Recruiting

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT04655404 2026-03-18

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

15 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT04943848 2026-03-17

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

36 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT01165333 2026-03-16

CILENT

32 enrolled

Phase EARLY_PHASE1 Recruiting

Diffuse Intrinsic Pontine Glioma, Glioma

NCT06333899 2026-03-12

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

15 enrolled

Phase 1/2 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma

NCT06639607 2026-03-10

PRiME II

68 enrolled

Phase 1 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Ependymoma, Medulloblastoma, Recurrence

NCT04837547 2026-03-09

PEACH

24 enrolled

Phase 1 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Neuroblastoma

NCT07076498 2026-02-25

Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation

20 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT05476939 2026-02-05

BIOMEDE 2

Phase 3 Recruiting

433 enrolled

Diffuse Intrinsic Pontine Glioma

NCT05762419 2026-01-28

FUS Etoposide for DMG

10 enrolled

Phase 1 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Brain Diseases, Brain Neoplasms, Glioma, Nervous System Neoplasms, Central Nervous System Neoplasms

NCT07331064 2026-01-09

GABRIEL

15 enrolled

Phase 2 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Recurrence, Rhabdoid Tumor

NCT04049669 2026-01-08

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

130 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma

NCT05009992 2025-12-17

PNOC022

360 enrolled

Diffuse Intrinsic Pontine Glioma

NCT05956821 2025-12-08

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age

20 enrolled

Phase 1 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Oligodendroglioma

NCT05768880 2025-11-20

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

72 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT03396575 2025-10-29

BRAVO

Phase 1 Terminated

11 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Influenza, Human, Xanthomatosis, Cerebrotendinous

NCT02742883 2025-09-16

A Study of Atengenal and Astugenal in Diffuse, Intrinsic Pontine Glioma (DIPG)

Phase 2 Suspended

1 enrolled

Diffuse Intrinsic Pontine Glioma

NCT04099797 2025-09-04

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

37 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Neoplasms, Germ Cell and Embryonal, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT06624371 2025-07-22

AflacBT2303

Phase EARLY_PHASE1 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Glioma, Medulloblastoma

NCT03893487 2025-07-11

PNOC016

30 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma, Medulloblastoma

NCT04804709 2025-06-08

Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG)

Phase 1 Terminated

5 enrolled 11 charts

Diffuse Intrinsic Pontine Glioma

NCT04749641 2025-06-06

ENACTING

16 enrolled

Diffuse Intrinsic Pontine Glioma

NCT02420613 2025-04-02

Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma

NCT06221553 2025-03-30

CMD03DIPG

9 enrolled

Phase EARLY_PHASE1 Completed

Diffuse Intrinsic Pontine Glioma

NCT02992015 2025-03-07

Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma

2 enrolled

Diffuse Intrinsic Pontine Glioma

NCT05298995 2025-02-05

GD2-CAR T Cells for Pediatric Brain Tumours

54 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal

NCT02960230 2025-01-22

H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas

Phase 1/2 Completed

50 enrolled 12 charts

Phase 1/2 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Glioma

NCT04758533 2024-12-27

AloCELYVIR

13 enrolled

Phase 1/2 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Medulloblastoma, Recurrence

NCT01837862 2024-07-05

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Phase 1/2 Completed

36 enrolled

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma, Gliosarcoma, Optic Nerve Glioma

NCT04911621 2024-05-08

ADDICT-pedGLIO

10 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Glioma

NCT06396481 2024-05-02

CSAγδTBMG

25 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma, Medulloblastoma

NCT05717699 2024-02-28

Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma, Drug-Related Side Effects and Adverse Reactions

NCT05717712 2024-02-28

Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma, Drug-Related Side Effects and Adverse Reactions

NCT04341311 2024-02-15

DIPG

Phase 1 Terminated

4 enrolled

Diffuse Intrinsic Pontine Glioma, Neoplasms, Recurrence

NCT04264143 2023-12-18

CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

9 enrolled

Diffuse Intrinsic Pontine Glioma

NCT03620032 2023-12-06

DIPG

Phase 2 Unknown

54 enrolled

Diffuse Intrinsic Pontine Glioma

NCT02644460 2023-10-26

AflacST1501

Phase NA Not yet recruiting

53 enrolled

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT06093165 2023-10-23

REMIT

59 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Brain Stem Neoplasms

NCT03841435 2023-09-13

Hypofractionated Radiotherapy for Recurrent DIPG

Phase NA Completed

5 enrolled

Diffuse Intrinsic Pontine Glioma

NCT04532229 2023-07-27

Nimotuzumab in Combined With Chemoradiotherapy to Treat the Newly Diagnosed Diffuse Intrinsic Pontine Glioma in Children

Phase 3 Unknown

48 enrolled

Diffuse Intrinsic Pontine Glioma

NCT02444546 2023-04-24

Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors

6 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioma, Medulloblastoma, Oligodendroglioma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03086616 2023-04-06

CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With Diffuse Intrinsic Pontine Glioma (DIPG) (PNOC 009)

6 enrolled