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NCT03914625 2026-04-13

A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

Phase 3 Active not recruiting

6,720 enrolled

LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Down Syndrome, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

NCT01190930 2026-03-31

Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

Phase 3 Active not recruiting

9,350 enrolled 51 charts

LymphoidOther hematologic neoplasm

Down Syndrome, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT06740162 2026-02-23

PACE

Phase NA Recruiting

376 enrolled

Autism Spectrum Disorder, Trisomy 13 Syndrome, Cri-du-Chat Syndrome, De Lange Syndrome, Down Syndrome, Fragile X Syndrome, Intellectual Disability, Motor Activity, Prader-Willi Syndrome, Rubinstein-Taybi Syndrome, WAGR Syndrome, Williams Syndrome, X-Linked Intellectual Disability, Neurodevelopmental Disorders

NCT07232134 2025-11-20

AML-DS-2025

Phase 3 Recruiting

100 enrolled

Other hematologic neoplasm

Down Syndrome, Leukemia, Myeloid, Acute

NCT04546399 2025-09-10

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Phase 2 Recruiting

461 enrolled

Lymphoid

Burkitt Lymphoma, Down Syndrome

NCT02521493 2025-08-01

Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

Phase 3 Active not recruiting

280 enrolled 13 charts

MyeloidOther hematologic neoplasm

Down Syndrome, Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Myeloid, Acute

NCT03836300 2025-07-31

Parent and Infant Inter(X)Action Intervention (PIXI)

Phase NA Enrolling by invitation

120 enrolled

Telomeric 22q13 Monosomy Syndrome, Developmental Disabilities, DiGeorge Syndrome, Down Syndrome, Fragile X Syndrome, Klinefelter Syndrome, Prader-Willi Syndrome, Tuberous Sclerosis, Turner Syndrome, Rett Syndrome, Angelman Syndrome, Williams Syndrome, Muscular Dystrophy, Duchenne, Smith-Magenis Syndrome

NCT03286634 2022-09-28

ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016

Phase 2 Recruiting

60 enrolled

LymphoidOther hematologic neoplasm

Down Syndrome, Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma