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Phase

Phase EARLY_PHASE1 2Phase 2 1Phase 1 1

Status

Withdrawn 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

CNS 1

Conditions

Precursor Cell Lymphoblastic Leukemia-Lymphoma 25Leukemia, Myeloid, Acute 17Leukemia 11Myelodysplastic Syndromes 10Recurrence 8Lymphoma 8Burkitt Lymphoma 8Leukemia, Biphenotypic, Acute 7Multiple Myeloma 6Osteosarcoma 5Lymphoma, Non-Hodgkin 5Sarcoma 4Lymphoma, T-Cell 4Lymphoma, Large B-Cell, Diffuse 4Lymphoma, Follicular 4Hodgkin Disease 4Hematologic Neoplasms 4Primary Myelofibrosis 3Neoplasms, Plasma Cell 3Leukemia, Myeloid 3Leukemia, Lymphocytic, Chronic, B-Cell 3Waldenstrom Macroglobulinemia 2Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 2Lymphoma, Mantle-Cell 2Lymphoma, Large-Cell, Immunoblastic 2Lymphoma, B-Cell, Marginal Zone 2Leukemia, Myelomonocytic, Juvenile 2Leukemia, Myelomonocytic, Chronic 2Leukemia, Myelogenous, Chronic, BCR-ABL Positive 2Leukemia, Lymphoid 2

Interventions

Temozolomide 11Filgrastim 5Magnetic Resonance Spectroscopy 4Cyclophosphamide 4Carmustine 4Thiotepa 3Radiation 3Etoposide 3Carboplatin 3Azacitidine 3Automobiles 3sargramostim 2Radiotherapy 2Peripheral Blood Stem Cell Transplantation 2ONC206 2O(6)-benzylguanine 2Nivolumab 2Melphalan 2Immunohistochemistry 2Imiquimod 2Imatinib Mesylate 2Granulocyte Colony-Stimulating Factor 22-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole 22,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide 21-methyltryptophan 2vitespin 1veliparib 1vatalanib 1trametinib 1thymoglobulin 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

1 trials
RecentStart dateEnrollment
Phase 1 × Ependymoma × Methotrexate × Clear all
NCT06466798 2026-01-08

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

The University of Texas Health Science Center, Houston

Phase 1 Withdrawn
CNS

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms

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