Clinical Trials

Esophageal Neoplasms

NCT05383482 2025-11-17

Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1

GastrointestinalGynecologic

22 enrolled

Uterine Cervical Neoplasms, Esophageal Neoplasms, Endometrial Neoplasms

NCT05007106 2025-08-14

KEYVIBE-005

BreastGastrointestinalGenitourinaryGynecologicHead & Neck

613 enrolled

Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Ovarian Neoplasms, Stomach Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma, Triple Negative Breast Neoplasms

NCT05714553 2025-07-18

NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours

Phase 1/2 Terminated

19 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Esophageal Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT04140526 2025-05-23

PRESERVE-001

Phase 1/2 Active not recruiting

733 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Adenoid Cystic, Esophageal Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Small Cell Lung Carcinoma

NCT06914687 2025-04-06

Efficacy of Tirellizumab Combined With Oral, Intravenous and Abdominal Chemotherapy in Peritoneal Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma

Phase 2 Not yet recruiting

30 enrolled

Phase 3 Active not recruiting

Esophageal Neoplasms, Stomach Neoplasms

NCT02509286 2024-05-08

ESOPEC

438 enrolled

Adenocarcinoma Of Esophagus, Adenocarcinoma, Esophageal Neoplasms

NCT02735239 2024-03-22

Study of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Oesophageal Cancer

73 enrolled 18 charts

Adenocarcinoma Of Esophagus, Diabetes Mellitus, Insulin-Dependent, 12, Parkinson Disease 4, Autosomal Dominant Lewy Body, Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT03099382 2024-01-22

Study of SHR-1210 Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal Cancer

457 enrolled 9 charts

Esophageal Neoplasms

NCT02465736 2024-01-16

Study of Docetaxel or Vinorelbine Plus Cisplatin in Neoadjuvant Chemoradiotherapy for Esophageal Cancer (NEOCRTEC308)

Phase 3 Unknown

610 enrolled

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT00551759 2023-07-03

Chemotherapy, Radiation Therapy, and Cetuximab Followed by Surgery, Docetaxel, and Cetuximab in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer

Phase 2 Terminated

22 enrolled 5 charts

Adenocarcinoma Of Esophagus, Esophageal Neoplasms

NCT00003864 2023-06-15

Docetaxel Plus Carboplatin in Treating Patients With Advanced Cancer of the Esophagus

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT00318903 2023-05-25

Irinotecan and Taxotere With Radiotherapy as Preoperative Treatment in Resectable Esophageal Cancer

25 enrolled

Esophageal Neoplasms

NCT05800054 2023-04-05

Effect of NST Whole-course Nutritional Management on Nutritional Status and Adverse Reactions in Esophageal Cancer

Phase NA Recruiting

210 enrolled

Esophageal Neoplasms, Drug-Related Side Effects and Adverse Reactions

NCT03933449 2023-03-29

KEYNOTE-181

123 enrolled 25 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Esophageal Neoplasms

NCT02564263 2023-03-13

KEYNOTE-181

628 enrolled 27 charts 2 FDA

Parkinson Disease 4, Autosomal Dominant Lewy Body, Esophageal Neoplasms

NCT01726452 2022-09-30

NEOadjuvant Trial in Adenocarcinoma of the oEsophagus and oesophagoGastric Junction International Study (Neo-AEGIS)

377 enrolled

Esophageal Neoplasms

NCT02569242 2022-07-06

Study of Nivolumab in Unresectable Advanced or Recurrent Esophageal Cancer

419 enrolled 20 charts 3 FDA

Esophageal Neoplasms

NCT00193128 2021-11-24

Preoperative Therapy With Oxaliplatin/Docetaxel/Capecitabine and Radiation in Resectable Esophagus Cancer

59 enrolled 8 charts

Esophageal Neoplasms

NCT01217060 2021-04-13

Trimodality Management of T1b Esophageal Cancers

4 enrolled 8 charts

Adenocarcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms

NCT02128243 2021-03-26

MATEO

242 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Neoplasm Metastasis, Stomach Neoplasms

NCT01822613 2020-12-19

Study of Safety & Efficacy of the Combination of LJM716 & BYL719 in Patients With Previously Treated Esophageal Squamous Cell Carcinoma (ESCC)

Phase 1 Completed

48 enrolled

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT01107639 2020-10-20

Radiation Therapy and Chemotherapy, With or Without Cetuximab, Followed by Surgery in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed by Surgery

297 enrolled

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT02403531 2020-06-02

Induction Chemotherapy Followed by Chemoradiotherapy in Esophageal Cancer

110 enrolled

Esophageal Neoplasms, Neoplasms

NCT04177875 2019-11-26

T+TP

44 enrolled

Esophageal Neoplasms

NCT01498289 2019-11-07

S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer

213 enrolled 17 charts

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT00217581 2019-03-26

Bevacizumab, Oxaliplatin, and Docetaxel in Treating Patients With Locally Advanced Unresectable or Metastatic Stomach or Gastroesophageal Junction Cancer

39 enrolled 10 charts

Esophageal Neoplasms, Stomach Neoplasms

NCT01715233 2019-03-15

Phase II Study Using CHFR Methylation Status in Patients With Metastatic Esophageal, Gastroesophageal, Gastric Cancer.

27 enrolled 10 charts

Esophageal Neoplasms, Stomach Neoplasms

NCT02177552 2019-02-15

SEED

98 enrolled

Esophageal Neoplasms, Stomach Neoplasms

NCT00137813 2018-11-01

Avastin and Taxotere for Esophagogastric Cancer

42 enrolled

Esophageal Neoplasms, Stomach Neoplasms

NCT03668418 2018-09-12

xenoZ

Unknown

120 enrolled

Biliary Tract Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Liver Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms

NCT02358863 2018-09-06

mEGA

Phase NA Terminated

13 enrolled 6 charts

Esophageal Neoplasms, Stomach Neoplasms

NCT03649945 2018-08-28

Endostatin Combined With Chemotherapy for Adjuvant Treatment of Esophageal Cancer

186 enrolled

Esophageal Neoplasms

NCT01608464 2018-08-10

Pre-op Chemo-RT w/CDDP/5FU vs Chemo w/ Docetaxel/Irinotecan in PET Non Responder Resectable Esophagus Cancer

Phase 2 Terminated

170 enrolled

Esophageal Neoplasms

NCT00938470 2018-03-29

Docetaxel, Oxaliplatin, Capecitabine, Fluorouracil, and Radiation Therapy in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction

73 enrolled 13 charts

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT00183872 2018-02-19

Study of Irinotecan and Docetaxel in Patients With Metastatic or Unresectable Gastric or Gastroesophageal Junction Adenocarcinoma

40 enrolled 10 charts

Esophageal Neoplasms, Stomach Neoplasms

NCT01693432 2017-08-23

Docetaxel and S-1 for Advanced Esophageal Cancer

37 enrolled

Esophageal Neoplasms

NCT00394433 2017-08-01

Docetaxel, Cisplatin, Irinotecan and Bevacizumab (TPCA) in Metastatic Esophageal and Gastric Cancer

38 enrolled 10 charts

Esophageal Neoplasms, Stomach Neoplasms

NCT00448760 2017-02-07

Combination Chemotherapy in Treating Patients With Previously Untreated Stage II or Stage III Esophageal Cancer That Can Be Removed By Surgery

29 enrolled 12 charts

Adenocarcinoma Of Esophagus, Esophageal Neoplasms

NCT03002064 2016-12-26

Docetaxol Plus Cisplatin Versus 5-Fu Plus Cisplatin as 1st-line Chemotherapy in Advanced ESCC Patients

Phase 3 Unknown

358 enrolled

Esophageal Neoplasms

NCT00054457 2016-12-13

Docetaxel and Capecitabine in Treating Patients With Metastatic Cancer of the Stomach or Gastroesophageal Junction

46 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT02969473 2016-11-21

Definitive Concurrent Chemoradiotherapy With Docetaxel Plus Cisplatin Versus 5-fluorouracil Plus Cisplatin in Patients With Esophageal Squamous Cell Carcinoma

120 enrolled

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT00004235 2016-07-14

Docetaxel and Irinotecan in Treating Patients With Advanced Cancer of the Esophagus or Stomach

47 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT01129206 2016-06-01

Pralatrexate and Docetaxel in Treating Patients With Stage IV Esophageal or Gastroesophageal Cancer Who Have Failed Platinum-Based Therapy

6 enrolled 6 charts

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Adenocarcinoma, Esophageal Neoplasms

NCT00390416 2016-03-14

Study of Docetaxel, Cisplatin, and Fluorouracil (Modified DCF) With Bevacizumab in Patients With Unresectable or Metastatic Gastroesophageal Adenocarcinoma

48 enrolled 8 charts

Esophageal Neoplasms, Neoplasm Metastasis, Stomach Neoplasms

NCT00757172 2016-03-11

Panitumumab, Docetaxel, Cisplatin, Radiation Therapy, and Surgery in Treating Patients With Newly Diagnosed, Locally Advanced Esophageal Cancer or Cancer of the Gastroesophageal Junction

70 enrolled 15 charts

Adenocarcinoma Of Esophagus, Esophageal Neoplasms

NCT00737438 2016-02-03

Pre-operative Chemotherapy Plus Bevacizumab With Early Salvage Therapy Based on PET Assessment of Response in Patients With Locally Advanced But Resectable Gastric and GEJ Adenocarcinoma

22 enrolled 6 charts

BreastCNSGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Esophageal Neoplasms, Stomach Neoplasms

NCT01172028 2015-12-03

Pemetrexed Disodium and Docetaxel in Treating Patients With Advanced Solid Tumors

Phase 1 Completed

33 enrolled

Carcinoma, Ovarian Epithelial, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Stomach Neoplasms, Esthesioneuroblastoma, Olfactory, Breast Neoplasms, Male

NCT00735345 2015-03-09

Chemotherapy Induction and Chemoradiotherapy in Patients With Esophageal Carcinoma

Phase 2 Terminated

50 enrolled