Clinical Trials Browser

Phase 3 × Interventional × Esophageal Neoplasms × Clear all

NCT07431281 2026-05-27

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

Phase 3 Recruiting

Gastrointestinal

Adenocarcinoma Of Esophagus, Adenocarcinoma, Esophageal Neoplasms, Stomach Neoplasms

NCT05152147 2026-05-19

HERIZON-GEA-01

Phase 3 Active not recruiting

Gastrointestinal

Adenocarcinoma Of Esophagus, Parkinson Disease 4, Autosomal Dominant Lewy Body, Esophageal Neoplasms, Stomach Neoplasms

NCT05357846 2026-04-30

PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy Plus Surgery for Locally Advanced ESCC (NEOCRTEC2101)

Phase 3 Recruiting

Gastrointestinal

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT07177794 2026-04-21

EC-CRT-008

Phase 3 Recruiting

Gastrointestinal

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT07217704 2026-04-20

FAPI-GO

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms, Stomach Neoplasms

NCT06964568 2026-04-17

CCRT Followed by PD-1 Inhibitor Maintenance Therapy in Locally Advanced ESCC

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT04540211 2026-04-09

SKYSCRAPER-08

Phase 3 Completed

461 enrolled 24 charts

Gastrointestinal

Esophageal Neoplasms

NCT01196390 2026-02-18

Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer

Phase 3 Completed

203 enrolled 22 charts

Gastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Neoplasms

NCT07406815 2026-02-12

The Value of Near-Infrared Fluorescence Imaging in the Protection of the Recurrent Laryngeal Nerve During Minimally Invasive Esophagectomy

Phase 3 Not yet recruiting

Gastrointestinal

Esophageal Neoplasms

NCT04871412 2026-01-30

POISE

Phase 3 Recruiting

GastrointestinalThoracic

Psychological Well-Being, Esophageal Neoplasms, Lung Neoplasms, Motor Activity, Stomach Neoplasms

NCT04821778 2026-01-21

Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT04821843 2026-01-21

Neoadjuvant Treatment Modalities in Esophageal Cancer

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT07332221 2026-01-12

Application of Toripalimab as Adjuvant Therapy After Esophageal Cancer Surgery: A Multicenter Clinical Trial

Phase 3 Not yet recruiting

Gastrointestinal

Esophageal Neoplasms

NCT06676449 2026-01-07

TDLN-sparing RT Plus Immunotherapy and Chemotherapy in Locally Advanced ESCC

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT07306663 2025-12-29

ESO-Nanjing7

Phase 3 Active not recruiting

Gastrointestinal

Esophageal Neoplasms

NCT07303231 2025-12-24

The Value of Indocyanine Green-guided Near-infrared Fluorescence Technology in Tracing Sentinel Lymph Nodes During Esophagectomy

Phase 3 Not yet recruiting

Gastrointestinal

Esophageal Neoplasms

NCT06914011 2025-12-03

MRD2START

Phase 3 Not yet recruiting

Gastrointestinal

Esophageal Neoplasms

NCT07211009 2025-10-07

Patient-Reported Symptom Care Versus Usual Care After Esophageal Cancer Surgery: A Single-Center Phase 3 Randomized Trial

Phase 3 Not yet recruiting

Gastrointestinal

Esophageal Neoplasms

NCT00680901 2025-08-07

LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib

Phase 3 Completed

545 enrolled 24 charts

Gastrointestinal

Esophageal Neoplasms, Neoplasm Metastasis, Neoplasms

NCT03847857 2025-06-12

Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage (PLACE030)

Phase 3 Active not recruiting

Gastrointestinal

Esophageal Neoplasms, Anastomotic Leak

NCT04415853 2025-05-18

Study of Larotinib in Unresectable Advanced or Recurrent Esophageal Cancer

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT04513418 2025-05-14

POINT

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT00357682 2025-05-01

AspECT

Phase 3 Completed

2,557 enrolled 17 charts

GastrointestinalOther neoplasm

Barrett Esophagus, Esophageal Neoplasms, Precancerous Conditions

NCT05865743 2025-03-05

PERSuaDER

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT02349412 2025-02-07

Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers

Phase 3 Completed

405 enrolled 11 charts

GastrointestinalOther solid neoplasmThoracic

Mesothelioma, Malignant, Anxiety Disorders, Bile Duct Neoplasms, Carcinoma, Non-Small-Cell Lung, Depression, Esophageal Neoplasms, Liver Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Small Cell Lung Carcinoma

NCT05055648 2024-12-17

PROTECT

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT04513808 2024-12-04

Total Intravenous Anesthesia and Recurrence Free Survival

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT03189719 2024-10-15

KEYNOTE-590

Phase 3 Completed

749 enrolled 40 charts 1 FDA

Gastrointestinal

Parkinson Disease 4, Autosomal Dominant Lewy Body, Esophageal Neoplasms

NCT05369234 2024-10-10

Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis

Phase 3 Completed

GastrointestinalHead & Neck

Esophageal Neoplasms, Laryngeal Neoplasms, Mediastinal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT02845479 2024-09-20

POISE

Phase 3 Completed

GastrointestinalThoracic

Esophageal Neoplasms, Lung Neoplasms, Stomach Neoplasms

NCT06086457 2024-07-16

PD-1 Inhibitor Plus Chemotherapy With or Without Radiotherapy in Patients With Metastatic Esophageal Cancer

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT06501664 2024-07-15

Liposomal Irinotecan and 5-FU as Second-line Therapy for Patients With ESCC

Phase 3 Not yet recruiting

Gastrointestinal

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT06339060 2024-07-03

PALACE3

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT02509286 2024-05-08

ESOPEC

Phase 3 Active not recruiting

Gastrointestinal

Adenocarcinoma Of Esophagus, Adenocarcinoma, Esophageal Neoplasms

NCT02556762 2024-02-06

SUMC-EC-002

Phase 3 Unknown

Gastrointestinal

Esophageal Neoplasms

NCT03099382 2024-01-22

Study of SHR-1210 Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal Cancer

Phase 3 Completed

457 enrolled 9 charts

Gastrointestinal

Esophageal Neoplasms

NCT02465736 2024-01-16

Study of Docetaxel or Vinorelbine Plus Cisplatin in Neoadjuvant Chemoradiotherapy for Esophageal Cancer (NEOCRTEC308)

Phase 3 Unknown

Gastrointestinal

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT06161909 2023-12-08

Postoperative Immune Maintenance Therapy for Esophageal Squamous Cell Carcinoma After Radical Resection

Phase 3 Unknown

Gastrointestinal

Esophageal Neoplasms

NCT06115629 2023-11-03

SARONG-II

Phase 3 Not yet recruiting

Gastrointestinal

Esophageal Neoplasms, Stomach Neoplasms

NCT03748134 2023-10-24

Sintilimab or Placebo With Chemotherapy in Esophageal Squamous Cell Carcinoma ( ORIENT-15 )

Phase 3 Completed

Gastrointestinal

Esophageal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Esophageal Diseases, Esophageal Neoplasms, Gastrointestinal Diseases, Neoplasms, Squamous Cell

NCT03790553 2023-08-03

Comparing 61.2 Gy Radiotherapy Dose Versus 50.4 Gy Radiotherapy Dose for Locally Advanced Esophageal Carcinoma

Phase 3 Unknown

Gastrointestinal

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT02853474 2023-04-26

EPIC-1511

Phase 3 Completed

Gastrointestinal

Bile Duct Neoplasms, Esophageal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms

NCT03933449 2023-03-29

KEYNOTE-181

Phase 3 Completed

123 enrolled 25 charts

Gastrointestinal

Parkinson Disease 4, Autosomal Dominant Lewy Body, Esophageal Neoplasms

NCT02564263 2023-03-13

KEYNOTE-181

Phase 3 Completed

628 enrolled 27 charts 1 FDA

Gastrointestinal

Parkinson Disease 4, Autosomal Dominant Lewy Body, Esophageal Neoplasms

NCT02395705 2022-10-05

Neoadjuvant Chemotherapy Versus Surgery Alone for Esophageal Squamous Cell Carcinoma

Phase 3 Completed

Gastrointestinal

Esophageal Neoplasms

NCT04280822 2022-10-04

Neo-adjuvant Immunochemotheray Versus Neo-adjuvant Chemotherapy for Resectable Esophageal Carcinoma

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT05547529 2022-10-04

The Efficacy of Neoadjuvant Chemoradiotherapy in Comparison With Neoadjuvant Chemotherapy in Patients With Resectable Squamous Cell Esophageal Cancer

Phase 3 Recruiting

Gastrointestinal

Esophageal Neoplasms

NCT01726452 2022-09-30

NEOadjuvant Trial in Adenocarcinoma of the oEsophagus and oesophagoGastric Junction International Study (Neo-AEGIS)

Phase 3 Completed

Gastrointestinal

Esophageal Neoplasms

NCT02569242 2022-07-06

Study of Nivolumab in Unresectable Advanced or Recurrent Esophageal Cancer

Phase 3 Completed

419 enrolled 20 charts 1 FDA

Gastrointestinal

Esophageal Neoplasms

NCT05188313 2022-06-24

TRAP-2

Phase 3 Recruiting

Gastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Neoplasms