Clinical Trials

Phase 2 Active not recruiting

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT01512589 2026-04-15

Proton Beam Therapy (PBT) Versus Intensity-Modulated Radiation Therapy (IMRT) Trial

147 enrolled

Adenocarcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms

NCT03161522 2026-04-15

Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer

100 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT03948100 2026-04-15

Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their Caregivers

400 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Lung Neoplasms

NCT07312526 2026-04-15

Shanghai Clinical Cohort - Esophageal Cancer

Completed

2,116 enrolled

Esophageal Neoplasms

NCT07519486 2026-04-15

INS-ESCC-CT

118 enrolled

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT07530094 2026-04-15

STELLAR01

98 enrolled

Phase 2 Not yet recruiting

Esophageal Neoplasms

NCT07530549 2026-04-15

A Phase II Single-arm Clinical Study in the Treatment of Locally Advanced Esophageal Cancer After Failed Neoadjuvant Chemoimmunotherapy

40 enrolled

Esophageal Neoplasms

NCT00260559 2026-04-14

Outcomes After Esophagectomy With a Focus on Minimally Invasive Esophagectomy and Quality of Life

3,500 enrolled

Esophageal Neoplasms

NCT00260585 2026-04-14

Esophageal Cancer Risk Registry

7,000 enrolled

Esophageal Achalasia, Esophageal Diseases, Esophageal Neoplasms, Gastroesophageal Reflux, Hernia, Hiatal

NCT06960889 2026-04-14

A Retrospective Clinical Study Exploring Prognostic Factors in Esophageal Cancer Patients

Active not recruiting

500 enrolled

GastrointestinalHead & NeckThoracic

Esophageal Neoplasms

NCT03102229 2026-04-13

RAMPART

Phase NA Completed

40 enrolled

Esophageal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Stomach Neoplasms

NCT05450484 2026-04-13

OPTIC

Phase 1 Completed

21 enrolled

Phase NA Not yet recruiting

Esophageal Neoplasms

NCT07518680 2026-04-08

A Clinical Study on the Effect of Massaging Tian Tu Acupoint on Coughing After Esophageal Surgery

Phase 2 Active not recruiting

Esophageal Neoplasms

NCT03764553 2026-04-07

LyRICX

320 enrolled

Esophageal Neoplasms

NCT05334069 2026-04-07

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

BreastDermatologicGastrointestinalGenitourinaryHead & NeckLymphoidMyeloidOther hematologic neoplasmSarcomaThoracic

2,000 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Esophageal Neoplasms, Lung Neoplasms, Melanoma, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT07283939 2026-04-07

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

420 enrolled

Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT00213486 2026-04-06

Weekly Cisplatin/Irinotecan and Radiotherapy in Patients With Locally Advanced Esophageal Cancer: Phase II Trial

Phase 2 Completed

43 enrolled

Esophageal Neoplasms

NCT04908111 2026-04-06

A Trial of ChAdOx1 and MVA Vaccines Against MAGE-A3 and NY-ESO-1

Phase 1/2 Suspended

15 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Lung Neoplasms, Neoplasms, Neoplasms, Squamous Cell

NCT06275737 2026-04-06

POP-UP

9 enrolled

Esophageal Neoplasms

NCT03482791 2026-04-02

Proton Beam Therapy in the Treatment of Esophageal Cancer

22 enrolled 29 charts

Phase 2 Active not recruiting

Esophageal Neoplasms

NCT05480384 2026-04-01

Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction

1 enrolled

Phase NA Not yet recruiting

Adenocarcinoma Of Esophagus, Esophageal Neoplasms

NCT07187154 2026-04-01

The Application of Symptoms Management Program Based on the Patient Reported Outcome After Esophagectomy

252 enrolled

Esophageal Neoplasms

NCT02530983 2026-03-30

UDD

1,000 enrolled

Digestive System Abnormalities, Esophageal Neoplasms

NCT05145647 2026-03-27

To Observe the Benefit of Adding Brachytherapy After CCRT on Resectable Esophageal Cancer Patients Without Surgery

18 enrolled

Esophageal Neoplasms

NCT06447064 2026-03-25

(CLOCS-2)

GastrointestinalGenitourinaryGynecologic

2,900 enrolled

Urinary Bladder Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Liver Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Uterine Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT06476678 2026-03-25

Novel Bipolar Radiofrequency Ablation Knife in Esophageal Lesions

50 enrolled

Esophageal Neoplasms

NCT07063901 2026-03-24

Multimodal Deep Learning for Predicting Treatment Response to Neoadjuvant Chemoimmunotherapy in Esophageal Cancer

200 enrolled

Phase 1 Active not recruiting

Esophageal Neoplasms

NCT03044613 2026-03-23

Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal Cancer

32 enrolled

Esophageal Neoplasms, Stomach Neoplasms

NCT06792786 2026-03-23

A Multicenter Prospective Study Evaluating Concurrent Chemoradiotherapy Following Induction Immunochemotherapy for Esophageal Cancer Based on Dynamic ctDNA Monitoring

BreastGastrointestinalGynecologicThoracic

Esophageal Neoplasms

NCT05143970 2026-03-20

CHANCES

Phase 1 Recruiting

27 enrolled

Breast Neoplasms, Esophageal Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Endometrial Neoplasms

NCT06343597 2026-03-20

Volume Outcome Relationships and Effects

Esophageal Neoplasms

NCT02359968 2026-03-18

PROTECT

Phase 2 Completed

106 enrolled

Esophageal Neoplasms

NCT02642809 2026-03-18

Pembrolizumab With Locally Delivered Radiation Therapy for the Treatment of Metastatic Esophageal Cancers

Phase 1 Completed

16 enrolled 13 charts

Esophageal Neoplasms

NCT04674267 2026-03-18

REACH

257 enrolled

Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT05187182 2026-03-18

CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

Phase 1 Recruiting

42 enrolled

Phase 1 Not yet recruiting

Esophageal Neoplasms, Stomach Neoplasms

NCT06735638 2026-03-18

Outside the Cage (OTC) Robotic Esophagectomy

31 enrolled

Esophageal Neoplasms, Ornithine Carbamoyltransferase Deficiency Disease

NCT06335966 2026-03-17

BEST-RPP

Active not recruiting

110 enrolled

Esophageal Neoplasms

NCT06652620 2026-03-16

Cola Ingestion for Esophageal Bolus Impaction

50 enrolled

Esophageal Neoplasms

NCT06349642 2026-03-12

ELEPHAS-04

DermatologicGastrointestinalGenitourinaryGynecologicSarcomaThoracic

324 enrolled

Clear-cell metastatic renal cell carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinosarcoma, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Neoplasm Metastasis, Skin Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT07464470 2026-03-12

GENCONCOR-2

CNSGastrointestinal

Brain Neoplasms, Esophageal Neoplasms, Stomach Neoplasms

NCT07102329 2026-03-11

ESCAPE

Completed

100,000 enrolled

Barrett Esophagus, Esophageal Neoplasms, Gastroesophageal Reflux, Eosinophilic Esophagitis

NCT07104214 2026-03-11

Development and Validation of a Risk Prediction Model for Gastric Retention in Patients Undergoing Sedated Gastroscopy

5,000 enrolled

Esophageal Neoplasms, Gastroparesis

NCT07132918 2026-03-11

HEARTS Trial for Thoracic Cancers

60 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Thymoma

NCT07175155 2026-03-11

Combination of COMBO Endoscopy Oropharyngeal Airway and HFNC Oxygenation in Sedated Gastrointestinal Endoscopy for Morbidly Obese Patients

410 enrolled

Hypoxia, Esophageal Neoplasms, Stomach Neoplasms

NCT06408116 2026-03-10

PEGASUS

Esophageal Neoplasms

NCT07354295 2026-03-10

Integrating Multimodal AI to Predict Treatment Response and Refine Risk Stratification in Esophageal Cancer （Radiogenomics-Esophagus）

1,500 enrolled

Esophageal Neoplasms

NCT07460596 2026-03-10

Concentrated Complex Plant Dietary Elements for Chemotherapy-Induced Diarrhea

Phase 2 Completed

Esophageal Neoplasms, Rectal Neoplasms

NCT05706558 2026-03-09

Retrospective Review of Esophageal Cancer at MSKCC

4,000 enrolled