Clinical Trials

Phase 2 Not yet recruiting

Esophageal Neoplasms

NCT07603375 2026-05-22

TNT Esophagus

60 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms

NCT07038629 2026-05-20

Chemoradiation Plus Iparomlimab Consolidation in Older With ESCC

52 enrolled

Esophageal Neoplasms

NCT04846309 2026-05-19

PIONEER

16 enrolled

Esophageal Neoplasms

NCT06414902 2026-05-19

18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer

60 enrolled

Esophageal Neoplasms

NCT07162506 2026-05-19

DCRT vs. Surgery in Resectable ESCC Patient Achiving cCR/PR After nCI

120 enrolled

Esophageal Neoplasms

NCT07561840 2026-05-19

Exercise Training After Upper Gastrointestinal Cancer Surgery

171 enrolled

Phase 1/2 Not yet recruiting

Disease, Esophageal Neoplasms, Gastrointestinal Neoplasms, Motor Activity, Stomach Neoplasms

NCT07594626 2026-05-19

BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion

72 enrolled

Phase NA Not yet recruiting

Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms

NCT07596732 2026-05-19

SUNRISE

120 enrolled

GastrointestinalThoracic

Colonic Neoplasms, Disease, Esophageal Neoplasms, Lung Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT04984733 2026-05-18

ELEVATE

Phase 2 Completed

13 enrolled

Esophageal Neoplasms, Neoplasms

NCT06251973 2026-05-15

A Study of agenT-797 in Combination With Botensilimab, Balstilimab, Ramucirumab, and Paclitaxel for People With Esophageal, Gastric, or Gastro-esophageal Junction Cancer

20 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT06673329 2026-05-13

Brodalumab in the Treatment of Immune-Related Adverse Events

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

11 enrolled

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms

NCT07581236 2026-05-12

A Single-center, Single-arm Clinical Study Evaluating the Short-term Efficacy of Inflatable Mediastinoscopic-assisted Transhiatal Laparoscopic Esophagectomy for the Radical Resection of Thoracic Esophageal Cancer

Phase NA Completed

35 enrolled

Phase 1 Active not recruiting

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT05667298 2026-05-11

OPERARADIO

11 enrolled

Esophageal Neoplasms

NCT07283939 2026-05-11

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

420 enrolled

BreastGastrointestinalGynecologicHead & NeckThoracic

Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT06380816 2026-05-08

A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer

Phase 1/2 Recruiting

167 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT07000253 2026-05-07

OMEC-5

Phase 2/3 Recruiting

290 enrolled

Esophageal Neoplasms, Neoplasms, Stomach Neoplasms

NCT04986293 2026-05-04

SISTER

31 enrolled

GastrointestinalLymphoid

Esophageal Neoplasms, Lymphoma, Radiation Injuries

NCT07307560 2026-05-04

High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients

600 enrolled

Hypoxia, Disease, Esophageal Neoplasms, Stomach Neoplasms, Sleep Apnea, Obstructive

NCT05297734 2026-04-30

Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicMyeloidSarcomaThoracic

2,996 enrolled

Carcinoma, Ovarian Epithelial, Breast Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Death, Esophageal Neoplasms, Glioblastoma, Lung Diseases, Lung Neoplasms, Melanoma, Myelodysplastic Syndromes, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Sarcoma, Osteosarcoma, Skin Neoplasms, Stomach Neoplasms, Thoracic Neoplasms, Urogenital Neoplasms, Disease Progression, Small Cell Lung Carcinoma

NCT05357846 2026-04-30

PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy Plus Surgery for Locally Advanced ESCC (NEOCRTEC2101)

Phase 3 Recruiting

422 enrolled

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT05187182 2026-04-27

CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

42 enrolled

Esophageal Neoplasms, Stomach Neoplasms

NCT06143748 2026-04-23

EC-CRT-006

46 enrolled

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT00937456 2026-04-22

Open Versus Laparoscopically-assisted Esophagectomy for Cancer

Phase NA Completed

207 enrolled

Esophageal Neoplasms, Neoplasms

NCT05480384 2026-04-21

Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction

1 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms

NCT07177794 2026-04-21

EC-CRT-008

Phase 3 Recruiting

242 enrolled

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT06964568 2026-04-17

CCRT Followed by PD-1 Inhibitor Maintenance Therapy in Locally Advanced ESCC

Phase 3 Recruiting

452 enrolled

Esophageal Neoplasms

NCT07223424 2026-04-16

PSI-Immune

DermatologicGastrointestinalGenitourinaryGynecologicThoracic

880 enrolled

Adenocarcinoma Of Esophagus, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Colitis, Ulcerative, Colonic Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma

NCT01512589 2026-04-15

Proton Beam Therapy (PBT) Versus Intensity-Modulated Radiation Therapy (IMRT) Trial

147 enrolled

Adenocarcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms

NCT03161522 2026-04-15

Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer

100 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT03948100 2026-04-15

Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their Caregivers

400 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Lung Neoplasms

NCT07519486 2026-04-15

INS-ESCC-CT

118 enrolled

Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT07530094 2026-04-15

STELLAR01

98 enrolled

Phase 2 Not yet recruiting

Esophageal Neoplasms

NCT07530549 2026-04-15

A Phase II Single-arm Clinical Study in the Treatment of Locally Advanced Esophageal Cancer After Failed Neoadjuvant Chemoimmunotherapy

40 enrolled

GastrointestinalHead & NeckThoracic

Esophageal Neoplasms

NCT03102229 2026-04-13

RAMPART

Phase NA Completed

40 enrolled

Esophageal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Stomach Neoplasms

NCT05450484 2026-04-13

OPTIC

Phase 1 Completed

21 enrolled

Phase NA Not yet recruiting

Esophageal Neoplasms

NCT07518680 2026-04-08

A Clinical Study on the Effect of Massaging Tian Tu Acupoint on Coughing After Esophageal Surgery

30 enrolled

Esophageal Neoplasms

NCT03764553 2026-04-07

LyRICX

320 enrolled

Esophageal Neoplasms

NCT00213486 2026-04-06

Weekly Cisplatin/Irinotecan and Radiotherapy in Patients With Locally Advanced Esophageal Cancer: Phase II Trial

Phase 2 Completed

43 enrolled

Phase NA Active not recruiting

Esophageal Neoplasms

NCT04908111 2026-04-06

A Trial of ChAdOx1 and MVA Vaccines Against MAGE-A3 and NY-ESO-1

Phase 1/2 Suspended

15 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Lung Neoplasms, Neoplasms, Neoplasms, Squamous Cell

NCT06275737 2026-04-06

POP-UP

9 enrolled

Phase NA Active not recruiting

Esophageal Neoplasms

NCT03482791 2026-04-02

Proton Beam Therapy in the Treatment of Esophageal Cancer

22 enrolled 29 charts

Phase NA Not yet recruiting

Esophageal Neoplasms

NCT07187154 2026-04-01

The Application of Symptoms Management Program Based on the Patient Reported Outcome After Esophagectomy

252 enrolled

Phase NA Active not recruiting

Esophageal Neoplasms

NCT05145647 2026-03-27

To Observe the Benefit of Adding Brachytherapy After CCRT on Resectable Esophageal Cancer Patients Without Surgery

18 enrolled

Phase 1 Active not recruiting

Esophageal Neoplasms

NCT03044613 2026-03-23

Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal Cancer

32 enrolled

Esophageal Neoplasms, Stomach Neoplasms

NCT06792786 2026-03-23

A Multicenter Prospective Study Evaluating Concurrent Chemoradiotherapy Following Induction Immunochemotherapy for Esophageal Cancer Based on Dynamic ctDNA Monitoring

30 enrolled