Announcements Trials
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Phase

Phase 1/2 2Phase 1 1

Status

Terminated 1Recruiting 1Active not recruiting 1

Sponsor Class

NIH 3INDUSTRY 1

Study Type

Interventional 3

Sponsor

Cancer Type

Gastrointestinal 3Thoracic 1Gynecologic 1Breast 1

Conditions

Melanoma 27Neoplasm Metastasis 16Skin Neoplasms 12Breast Neoplasms 9Multiple Myeloma 8Kidney Neoplasms 8Precursor Cell Lymphoblastic Leukemia-Lymphoma 7Pancreatic Neoplasms 7Ovarian Neoplasms 7Lymphoma 7Leukemia, Lymphocytic, Chronic, B-Cell 7Leukemia 7Hematologic Neoplasms 7Neoplasms 6Myelodysplastic Syndromes 6Leukemia, Myeloid, Acute 6Uterine Cervical Neoplasms 5Lymphoma, Non-Hodgkin 5Lymphoma, B-Cell 5Carcinoma, Non-Small-Cell Lung 5Urogenital Neoplasms 4Stomach Neoplasms 3Lung Neoplasms 3Liver Neoplasms 3Gastrointestinal Neoplasms 3Colorectal Neoplasms 3Colonic Neoplasms 3Carcinoma, Renal Cell 3Vaginal Neoplasms 2Rectal Neoplasms 2

Interventions

fludarabine 3aldesleukin 3Fluorouracil 3Cyclophosphamide 3Oxaliplatin 2Leucovorin 2Interleukin-2 2Gemcitabine 2sodium thiosulfate 1montanide ISA 51 1fludarabine phosphate 1detox adjuvant 1dehydroftorafur 1danvatirsen 1Tomography, X-Ray Computed 1Specimen Handling 1Positron-Emission Tomography 1Plicamycin 1Photography 1National Cancer Institute (U.S.) 1Mitomycin 1Microscopy, Electron 1Melphalan 1Magnetic Resonance Imaging 1MLN 8237 1Floxuridine 1Erlotinib Hydrochloride 1Electrocardiography 1Doxorubicin 1Diagnostic Imaging 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
NIH × Gastrointestinal Neoplasms × fludarabine × Clear all
NCT03190941 2026-05-29

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

National Institutes of Health Clinical Center (CC)

Phase 1/2 Recruiting
110 enrolled
Gastrointestinal

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT03745326 2026-05-19

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

National Institutes of Health Clinical Center (CC)

Phase 1/2 Terminated
5 enrolled 14 charts
Gastrointestinal

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT06253520 2026-05-08

Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer

National Institutes of Health Clinical Center (CC)

Phase 1 Active not recruiting
210 enrolled
BreastGastrointestinalGynecologicThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Gastrointestinal Neoplasms, Ovarian Neoplasms, Urogenital Neoplasms, Colorectal Neoplasms

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