Clinical Trials

Digestive System Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT07039526 2026-06-05

Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detection of Malignant Tissue in Subjects Undergoing Surgical Resection for Cancer.

50 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Esophageal Neoplasms, Gastrointestinal Neoplasms

NCT07627191 2026-06-05

GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer

30 enrolled

Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Pancreatic Neoplasms, Colorectal Neoplasms

NCT04700527 2026-06-03

The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study

Phase 1/2 Recruiting

122 enrolled

Gastrointestinal Neoplasms, Radiation Injuries

NCT07456852 2026-06-02

Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy

Phase 1/2 Recruiting

60 enrolled

Gastrointestinal Neoplasms

NCT05664178 2026-06-01

Remote Resistance Exercise Powering Survivors - Gastrointestinal Oncology

Phase 1/2 Completed

22 enrolled

Gastrointestinal Neoplasms

NCT07606287 2026-05-29

Studying the Workflow of the American College of Surgeons Geriatric Surgery Program to Improve Clinical Outcomes in Older Adults Undergoing Surgery at the James Cancer Hospital

BreastCNSDermatologicGastrointestinalHead & Neck

4,000 enrolled

Breast Neoplasms, Endocrine Gland Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Skin Neoplasms, Soft Tissue Neoplasms, Urogenital Neoplasms, Central Nervous System Neoplasms

NCT06551675 2026-05-27

Effect of Silkworm Pupa Tablets in Gastrointestinal Malignancies at Nutritional Risk Following Radical Surgery

120 enrolled

Frailty, Gastrointestinal Neoplasms, Malnutrition

NCT07405307 2026-05-27

Sarcopenia Risk Screening in Patients With Gastrointestinal Cancer Using SARC-F

Completed

44 enrolled

Gastrointestinal Neoplasms, Sarcopenia

NCT06263088 2026-05-22

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

EndocrineGastrointestinalNET

200 enrolled

Anus Neoplasms, Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Neuroendocrine Tumors

NCT04588246 2026-05-20

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Phase 3 Terminated

19 enrolled 19 charts

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Small Cell Lung Carcinoma

NCT07561840 2026-05-19

Exercise Training After Upper Gastrointestinal Cancer Surgery

171 enrolled

Phase 1/2 Not yet recruiting

Disease, Esophageal Neoplasms, Gastrointestinal Neoplasms, Motor Activity, Stomach Neoplasms

NCT07594626 2026-05-19

BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion

72 enrolled

Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms

NCT07590622 2026-05-15

EAT-ING

88 enrolled

Gastrointestinal Neoplasms

NCT01269567 2026-05-14

GRECCAR 5

Phase 3 Completed

494 enrolled

Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT07586813 2026-05-14

N01-A-PICIT-GI

Classical hematologyGastrointestinal

220 enrolled

Pathologic Complete Response, Digestive System Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Thrombocytopenia, Colorectal Neoplasms

NCT07575854 2026-05-13

SPLENIC-SIRT

18 enrolled

Gastrointestinal Neoplasms, Splenomegaly

NCT01624220 2026-05-12

A Prospective Study Using Implanted Fiducial Markers to Assess Treatment Accuracy and Esophageal Toxicity in Spinal Stereotactic Body Radiation Therapy

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

41 enrolled 8 charts

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Prostatic Neoplasms, Sarcoma, Spinal Cord Neoplasms, Thyroid Neoplasms

NCT07283939 2026-05-11

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

420 enrolled

Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT07524114 2026-05-11

SHERLOCK

BreastDermatologicGastrointestinalHead & NeckThoracic

7,000 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Unknown Primary, Urogenital Neoplasms, Neoplasm, Residual

NCT04541381 2026-05-07

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

Phase NA Suspended

860 enrolled

BreastGastrointestinalHead & Neck

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Dihydropyrimidine Dehydrogenase Deficiency

NCT05220046 2026-05-06

Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers

Phase 1 Active not recruiting

24 enrolled

Biliary Tract Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms

NCT07003061 2026-04-30

Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery

Completed

100 enrolled

Gastrointestinal Neoplasms, Sarcopenia

NCT07558330 2026-04-30

CODAP

555 enrolled

Gastrointestinal Neoplasms

NCT07558447 2026-04-30

CHEMOVES

BreastGastrointestinalGenitourinaryHead & NeckThoracic

120 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Neoplasms, Urologic Neoplasms, Neurotoxicity Syndromes

NCT04084249 2026-04-29

ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial

Phase NA Active not recruiting

359 enrolled

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Neoplasms, Rectal Diseases, Rectal Neoplasms, Colorectal Neoplasms

NCT05694338 2026-04-29

Frailty in Patients With Gastrointestinal Cancer Who Are Undergoing Major Surgery

100 enrolled

Gastrointestinal Neoplasms

NCT06936878 2026-04-28

BOLSTER

600 enrolled

Phase 3 Not yet recruiting

Gastrointestinal Neoplasms

NCT07554807 2026-04-28

A Randomized, Double-blind, Placebo-controlled, Prospective, Multi-center Trial Evaluating the Improvement of Nutritional Status and Sarcopenia With Silkworm Pupa Tablets in Patients With Malignancies

480 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Gastrointestinal Neoplasms, Malnutrition, Sarcopenia

NCT07389525 2026-04-24

Immune Checkpoint Inhibitor (ICI)-Drug-Drug Interaction (DDI) Study

80 enrolled

DermatologicGastrointestinalSarcoma

Gastrointestinal Neoplasms, Melanoma, Sarcoma, Urogenital Neoplasms

NCT06475352 2026-04-23

FUDOSE

400 enrolled

Phase 2 Active not recruiting

Gastrointestinal Neoplasms, Neoplasm Metastasis, Neoplasms, Recurrence, Colorectal Neoplasms

NCT02713269 2026-04-17

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

60 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Sarcoma, Spinal Cord Compression, Thyroid Neoplasms

NCT05179486 2026-04-17

Molecular Epidemiology of Biliary Tree Cancers

1,500 enrolled

Gastrointestinal Neoplasms, Cholangiocarcinoma

NCT05789485 2026-04-16

A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers

216 enrolled

Gastrointestinal Neoplasms, Motor Activity

NCT03115398 2026-04-13

A Simple Walking Program to Enhance Concurrent Chemoradiotherapy Delivery

CNSGastrointestinalGynecologicHead & NeckThoracic

166 enrolled

Brain Neoplasms, Uterine Cervical Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms

NCT05313191 2026-04-13

ReRT

BreastCNSGastrointestinalGenitourinaryHead & Neck

1,800 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Neoplasms, Prostatic Neoplasms, Central Nervous System Neoplasms

NCT07215624 2026-04-08

STOP-VTE

500 enrolled

Gastrointestinal Neoplasms, Urogenital Neoplasms

NCT05107219 2026-04-07

GCC Agonist Signal in the Small Intestine

Phase 1 Completed

43 enrolled

Barrett Esophagus, Gastroesophageal Reflux, Gastrointestinal Neoplasms

NCT06048146 2026-04-06

A Prospective, Multicenter Randomized Controlled Study of the Application of Preoperative FOLFOXIRI Chemotherapy Combined With Lateral Lymph Node Dissection in Low- and Medium-lying Rectal Cancer With Lateral Lymph Node Metastasis

180 enrolled

Gastrointestinal Neoplasms, Intestinal Neoplasms, Lymphatic Metastasis, Rectal Diseases, Rectal Neoplasms

NCT06509022 2026-04-06

Longitudinal Study on the Evolution Trend and Influencing Factors of Postoperative Reflux of Esophageal Cancer Based on PEPTEST Technique

Enrolling by invitation

138 enrolled

Gastrointestinal Neoplasms

NCT05984589 2026-04-02

Personalized Health Self-Management Training for Colorectal Cancer Survivors

120 enrolled

Phase 2 Active not recruiting

Gastrointestinal Neoplasms, Colorectal Neoplasms, Health Behavior

NCT05318027 2026-04-01

ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy

70 enrolled

GastrointestinalHead & NeckThoracic

Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms

NCT05743426 2026-03-30

Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies

180 enrolled

GastrointestinalSarcoma

Gastrointestinal Neoplasms, Sarcoma

NCT05837767 2026-03-30

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

BreastDermatologicGastrointestinalGenitourinarySarcomaThoracic

26 enrolled

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasm Metastasis, Pancreatic Neoplasms, Sarcoma, Carcinoma, Ductal, Breast, Carcinoma, Lobular

NCT05984602 2026-03-30

A Phase IB Study to Determine the Safety and Tolerability of Canakinumab and Tislelizumab in Combination With Nab-Paclitaxel and Gemcitabine in the Neo-adjuvant Treatment of Patients With Pancreatic Cancer

Phase 1 Active not recruiting

9 enrolled

Phase NA Active not recruiting

Gastrointestinal Neoplasms, Pancreatic Neoplasms

NCT04986566 2026-03-27

Perioperative Telemonitoring to Optimize Cancer Care and Outcomes

134 enrolled 11 charts

Gastrointestinal Neoplasms

NCT05142033 2026-03-27

ASAP

BreastCNSGastrointestinalGynecologicOther hematologic neoplasmThoracic

25,000 enrolled

Breast Neoplasms, Colonic Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Neoplasms, Ovarian Neoplasms, Central Nervous System Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT04919824 2026-03-24

Monopolar Current Cutting Knife vs Bipolar RFA Knife

Phase NA Active not recruiting

80 enrolled

Gastrointestinal Neoplasms

NCT06134687 2026-03-24

Novel Rigidizing Overtube in Colonic Endoscopic Submucosal Dissection

66 enrolled