Clinical Trials

BreastCNSGastrointestinalGenitourinaryHead & Neck

1,800 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Neoplasms, Prostatic Neoplasms, Central Nervous System Neoplasms

NCT06582017 2026-04-13

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

BreastGastrointestinalGenitourinaryGynecologicThoracic

100 enrolled

Breast Neoplasms, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms

NCT06663319 2026-04-13

A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers

220 enrolled

BreastGastrointestinalGenitourinaryGynecologicSarcoma

Gastrointestinal Neoplasms, Colorectal Neoplasms

NCT06760819 2026-04-08

panSOHO

Phase 2 Recruiting

111 enrolled

Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Gastrointestinal Stromal Tumors

NCT07222800 2026-04-08

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

Phase 3 Recruiting

800 enrolled

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasm Metastasis, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT07283939 2026-04-07

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

420 enrolled

Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT03093116 2026-04-03

TRIDENT-1

EndocrineGastrointestinalHead & NeckNETSarcomaThoracic

500 enrolled 5 FDA

Adenocarcinoma, Bronchial Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Diseases, Colonic Neoplasms, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Neuroectodermal Tumors, Carcinoma, Neuroendocrine, Neuroendocrine Tumors

NCT07020221 2026-04-03

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

295 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Gastrointestinal Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Colorectal Neoplasms

NCT07218926 2026-04-03

A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

Phase 3 Recruiting

450 enrolled

GastrointestinalSarcoma

Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors

NCT05984589 2026-04-02

Personalized Health Self-Management Training for Colorectal Cancer Survivors

120 enrolled

Gastrointestinal Neoplasms, Colorectal Neoplasms, Health Behavior

NCT06445062 2026-04-01

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

1,130 enrolled

Gastrointestinal Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal

NCT05837767 2026-03-30

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

BreastDermatologicGastrointestinalGenitourinarySarcomaThoracic

26 enrolled

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasm Metastasis, Pancreatic Neoplasms, Sarcoma, Carcinoma, Ductal, Breast, Carcinoma, Lobular

NCT06134687 2026-03-24

Novel Rigidizing Overtube in Colonic Endoscopic Submucosal Dissection

66 enrolled

Gastrointestinal Neoplasms

NCT06159634 2026-03-24

Traction vs. No Traction in Colonic ESD

150 enrolled

Gastrointestinal Neoplasms

NCT04674267 2026-03-18

REACH

257 enrolled

Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT06596694 2026-03-16

Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)

180 enrolled

Gastrointestinal Neoplasms

NCT06681233 2026-03-13

Feasibility Study of CBCT for IGRT in Cancer Patients

BreastGastrointestinalHead & Neck

50 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Urogenital Neoplasms

NCT07176559 2026-03-12

PRaCTIS

36 enrolled

GastrointestinalThoracic

Gastrointestinal Neoplasms, Lung Neoplasms

NCT06569693 2026-03-09

Dyadic Sleep Study

152 enrolled

Gastrointestinal Neoplasms

NCT04541381 2026-03-04

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

BreastGastrointestinalHead & Neck

860 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Dihydropyrimidine Dehydrogenase Deficiency

NCT06936878 2026-03-02

BOLSTER

600 enrolled

Gastrointestinal Neoplasms

NCT05664178 2026-02-27

Remote Resistance Exercise Powering Survivors - Gastrointestinal Oncology

100 enrolled

Phase EARLY_PHASE1 Recruiting

Gastrointestinal Neoplasms

NCT06511037 2026-02-27

PhI Pilot Study Pafolacianine Inject for Intraoperative Imaging on Outcomes of GI Cancer Peritoneal Carcinomatosis

10 enrolled

GastrointestinalGynecologic

Gastrointestinal Neoplasms, Peritoneal Neoplasms

NCT06855524 2026-02-24

Fucoidan for Preventing Chemotherapy-Related Fatigue in Patients With Gastrointestinal or Gynecological Cancer

Phase 2 Recruiting

34 enrolled

Gastrointestinal Neoplasms

NCT04907643 2026-02-20

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

EndocrineGastrointestinalNET

360 enrolled

Cancer Pain, Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Biliary Tract Neoplasms, Carcinoid Tumor, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Rectal Neoplasms, Recurrence, Stomach Neoplasms, Neuroendocrine Tumors, Visceral Pain

NCT07337525 2026-02-18

A First in Human Study of PLT012 in Participants With Solid Tumor Cancers

GastrointestinalGenitourinary

36 enrolled

Urinary Bladder Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms

NCT07404527 2026-02-13

Bioelectrical Impedance Analysis for Perioperative Fluid Evaluation in Colorectal Cancer Surgery

60 enrolled

Digestive System Neoplasms, Gastrointestinal Neoplasms

NCT07329894 2026-02-12

Safety, Tolerance and Preliminary Efficacy of XH001 Injection Combined With Neoantigen Vaccine-induced Tumor-specific T-cell Injection in Advanced Gastrointestinal Cancer

18 enrolled

Gastrointestinal Neoplasms

NCT07383935 2026-02-11

Stress Ball Use During Chemotherapy in Gastrointestinal Cancer Patients

60 enrolled

Gastrointestinal Neoplasms

NCT06128551 2026-02-10

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

GastrointestinalGynecologicThoracic

534 enrolled

Appendiceal Neoplasms, Bronchial Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Stomach Neoplasms, Thoracic Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Carcinoma, Pancreatic Ductal

NCT06489041 2026-02-02

Evaluating Microarray Pharmacogenetic Testing in Cancer Patients

120 enrolled

Gastrointestinal Neoplasms, Neoplasms

NCT05150691 2026-01-28

A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

BreastGastrointestinalGynecologicThoracic

796 enrolled

Bile Duct Neoplasms, Biliary Tract Neoplasms, Breast Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasm Metastasis, Neoplasms, Recurrence, Stomach Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma

NCT06532877 2026-01-23

Telephone Support in Advanced Gastrointestinal Cancer

488 enrolled

Caregiver Burden, Fatigue, Gastrointestinal Neoplasms

NCT07056777 2026-01-13

Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer

186 enrolled

Gastrointestinal Neoplasms

NCT07319364 2026-01-06

A Real-World Study of Fecal Transplants for Cancer Therapy Side Effects

90 enrolled

Gastrointestinal Neoplasms, Drug-Related Side Effects and Adverse Reactions

NCT05066139 2026-01-05

EPODIG-G

144 enrolled

Digestive System Diseases, Gastrointestinal Neoplasms, Neoplasms

NCT06715839 2025-12-31

Target-specific immunoPET Imaging of Digestive System Carcinoma

400 enrolled

Simpson-Golabi-Behmel syndrome, Appendiceal Neoplasms, Bile Duct Neoplasms, Colonic Neoplasms, Digestive System Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT06420206 2025-12-30

Goals of Care Discussion for Patients With Advanced Lung and Gastrointestinal Cancer in the Emergency Department of a Comprehensive Cancer Center

200 enrolled

GastrointestinalThoracic

Gastrointestinal Neoplasms, Lung Neoplasms

NCT04530890 2025-12-24

Interest of Circulating Tumor DNA in Digestive and Gynecologic/Breast Cancer

1,000 enrolled

BreastGastrointestinal

Breast Neoplasms, Gastrointestinal Neoplasms

NCT06065371 2025-12-19

Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy

20 enrolled

Biliary Tract Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT06375187 2025-12-11

KUNLUN-001

BreastGastrointestinalThoracic

18 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms

NCT04700527 2025-12-10

The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study

122 enrolled

Gastrointestinal Neoplasms, Radiation Injuries

NCT03190941 2025-12-02

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

110 enrolled

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT06222645 2025-11-18

PPG vs. ICG in Gastrointestinal Resections

200 enrolled

Gastrointestinal Neoplasms, Postoperative Complications, Stomach Neoplasms, Colorectal Neoplasms, Anastomotic Leak

NCT06885034 2025-11-18

A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed

320 enrolled

Gastrointestinal Neoplasms, Colorectal Neoplasms

NCT05489237 2025-11-17

First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors

278 enrolled

GastrointestinalSarcoma

Digestive System Diseases, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Neoplasm Metastasis, Gastrointestinal Stromal Tumors

NCT05379985 2025-11-12

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

DermatologicGastrointestinalThoracic

754 enrolled

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplastic Processes, Pancreatic Neoplasms, Thoracic Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal

NCT03800693 2025-11-06

2 Versus 6 Hour Oxaliplatin Infusions in Patients With Gastrointestinal Cancers

Phase 2 Recruiting

60 enrolled