Clinical Trials

Digestive System Neoplasms, Gastrointestinal Stromal Tumors

NCT05957367 2026-04-16

A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies

Phase 1/2 Recruiting

94 enrolled

BreastDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

Gastrointestinal Stromal Tumors

NCT05461430 2026-04-13

TraveraRTGx

Completed

72 enrolled

Anus Neoplasms, Appendiceal Neoplasms, Ascites, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Laryngeal Neoplasms, Lung Neoplasms, Melanoma, Mesothelioma, Mouth Neoplasms, Nasopharyngeal Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Stomach Neoplasms, Thymoma, Vulvar Neoplasms, Pleural Effusion, Malignant, Carcinoma, Neuroendocrine, Cholangiocarcinoma, Carcinoma, Small Cell, Carcinoma, Pancreatic Ductal, Gastrointestinal Stromal Tumors

NCT03594422 2026-04-09

A Study of HQP1351 in Patients With GIST or Other Solid Tumors

100 enrolled

BreastGastrointestinalGenitourinaryGynecologicSarcoma

Gastrointestinal Stromal Tumors

NCT06760819 2026-04-08

panSOHO

Phase 2 Recruiting

111 enrolled

Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Gastrointestinal Stromal Tumors

NCT04633122 2026-04-03

A Study to Assess DCC-2618 and Sunitinib in Patients With Advanced GIST After Treatment With Imatinib

108 enrolled 11 charts

Gastrointestinal Stromal Tumors

NCT07218926 2026-04-03

A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

Phase 3 Recruiting

450 enrolled

Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors

NCT06948955 2026-04-02

Expanded Access to Bezuclastinib to be Coadministered With Sunitinib for Patients With Gastrointestinal Stromal Tumors

Available

Phase 4 Active not recruiting

Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors

NCT01742299 2026-04-01

Study to Allow Access to Imatinib for Patients Who Are on Imatinib Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator

155 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Gastrointestinal Stromal Tumors

NCT07124000 2026-03-31

DP-04

Recruiting

100 enrolled

Adenocarcinoma, Anus Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Melanoma, Mouth Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Testicular Neoplasms, Thyroid Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms, Gastrointestinal Stromal Tumors, Small Cell Lung Carcinoma

NCT05381753 2026-02-11

Safety and Efficacy of Avapritinib in Chinese Patients With Gastrointestinal Stromal Tumor (GIST) in the Real World

Completed

61 enrolled

Phase 3 Active not recruiting

Gastrointestinal Stromal Tumors

NCT03673501 2026-02-05

INTRIGUE

453 enrolled 20 charts

Gastrointestinal Stromal Tumors

NCT06630234 2026-02-05

A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)

Phase 1/2 Recruiting

120 enrolled

Gastrointestinal Stromal Tumors

NCT06655246 2026-02-05

A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

157 enrolled

Phase 3 Active not recruiting

Gastrointestinal Stromal Tumors

NCT05208047 2026-02-04

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

442 enrolled

Phase 2/3 Not yet recruiting

Neoplasm Metastasis, Gastrointestinal Stromal Tumors

NCT07379047 2026-01-30

GISTAR-1

255 enrolled

Gastrointestinal Stromal Tumors

NCT00756509 2026-01-20

Treatment of Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumors in First Line With Nilotinib

Phase 4 Completed

34 enrolled 11 charts

Phase 1 Active not recruiting

Gastrointestinal Stromal Tumors

NCT05245968 2026-01-20

A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101)

78 enrolled

Phase 3 Active not recruiting

Gastrointestinal Stromal Tumors

NCT05734105 2025-12-17

INSIGHT

54 enrolled

Gastrointestinal Stromal Tumors

NCT06619275 2025-12-05

INTEREST

Completed

10 enrolled

Gastrointestinal Stromal Tumors

NCT05489237 2025-11-17

First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors

278 enrolled

GastrointestinalHead & NeckSarcomaThoracic

Digestive System Diseases, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Neoplasm Metastasis, Gastrointestinal Stromal Tumors

NCT04000529 2025-09-30

Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies

Phase 1 Terminated

122 enrolled

Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms, Gastrointestinal Stromal Tumors

NCT06805825 2025-09-23

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

DermatologicEndocrineGastrointestinalGenitourinaryNETSarcomaThoracic

67 enrolled

Uveal Melanoma, Carcinoma, Renal Cell, Carcinoma, Adenoid Cystic, Piebaldism, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors, Small Cell Lung Carcinoma

NCT04282980 2025-03-03

A Study of DCC-2618 (Ripretinib) In Patients With With Advanced Gastrointestinal Stromal Tumors (GIST)

39 enrolled 13 charts

Gastrointestinal Stromal Tumors

NCT02401815 2025-02-14

CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors

Phase 1/2 Completed

51 enrolled 32 charts

CNSGastrointestinalSarcoma

Gastrointestinal Stromal Tumors

NCT04908176 2024-12-13

A Drug-drug Interaction Study of Avapritinib and Midazolam

Phase 1 Completed

10 enrolled

Glioblastoma, Neoplasms, Recurrence, Gastrointestinal Stromal Tumors

NCT04825574 2024-11-26

Study for Patients Previously Treated in Avapritinib Clinical Trials

Phase 4 Completed

2 enrolled 4 charts

CNSGastrointestinalSarcoma

Gastrointestinal Stromal Tumors

NCT04714086 2024-10-24

Expanded Access Program for Avapritinib

No longer available

Glioma, Gastrointestinal Stromal Tumors

NCT03345485 2024-10-21

EDO-S101

Phase 1/2 Completed

71 enrolled 39 charts

BreastGastrointestinalGynecologicSarcomaThoracic

Breast Neoplasms, Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Recurrence, Sarcoma, Endometrial Neoplasms, Gastrointestinal Stromal Tumors, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT04530981 2024-09-19

A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST

Phase 1 Completed

13 enrolled

Gastrointestinal Stromal Tumors

NCT01863745 2024-08-19

Nilotinib Roll-over Protocol for Patients in Novartis-sponsored Nilotinib Study and Benefiting From Nilotinib Treatment

15 enrolled 7 charts

Neoplasms, Gastrointestinal Stromal Tumors

NCT01294202 2024-08-02

A Study to Investigate the Safety and Efficacy of AT13387, Alone or in Combination With Imatinib, in Patients With GIST

26 enrolled

Neoplasm Metastasis, Gastrointestinal Stromal Tumors

NCT05160168 2024-06-05

A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

Phase 1/2 Terminated

32 enrolled 20 charts

BreastDermatologicGastrointestinalGenitourinarySarcoma

Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Connective Tissue, Neoplasms, Connective and Soft Tissue, Gastrointestinal Stromal Tumors

NCT04714983 2024-04-09

DNX-2440 for Resectable Colorectal Liver Metastasis

Phase 1 Suspended

30 enrolled

Breast Neoplasms, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Melanoma, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Gastrointestinal Stromal Tumors

NCT04276415 2024-02-15

DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST)

Phase 1 Terminated

34 enrolled 27 charts

Gastrointestinal Stromal Tumors

NCT04409223 2024-02-09

Efficacy and Safety of Famitinib Versus Sunitinib in the Treatment of Advanced Gastrointestinal Stromal Tumour Patients After Failure of Imatinib

Phase 3 Terminated

185 enrolled

GastrointestinalLymphoidMyeloidOther hematologic neoplasmSarcoma

Gastrointestinal Stromal Tumors

NCT01735955 2024-02-08

Study to Allow Access to Nilotinib for Patients Who Are on Nilotinib Treatment in a Novartis-sponsored Study

Phase 4 Completed

57 enrolled 8 charts

Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Piebaldism, Gastrointestinal Stromal Tumors, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT02571036 2023-12-13

A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies

Phase 1 Completed

282 enrolled

CNSDermatologicGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmSarcomaThoracic

Mast Cell Activation Disorders, Carcinoma, Non-Small-Cell Lung, Glioma, Leukemia, Mast-Cell, Melanoma, Neoplasms, Germ Cell and Embryonal, Penile Neoplasms, Sarcoma, Mastocytosis, Systemic, Gastrointestinal Stromal Tumors, Renal Insufficiency

NCT02232620 2023-11-14

A Study of BBI503 in Adult Patients With Advanced Gastrointestinal Stromal Tumors

Phase 2 Terminated

2 enrolled

Gastrointestinal Stromal Tumors

NCT02034110 2023-08-21

Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers