Announcements Trials
Browse Landscape

Phase

Phase 1 4

Status

Recruiting 3Active not recruiting 1

Sponsor Class

OTHER 4

Study Type

Interventional 4

Sponsor

Cancer Type

CNS 4Lymphoid 1

Conditions

Lymphoma, Large B-Cell, Diffuse 10Precursor Cell Lymphoblastic Leukemia-Lymphoma 6Lymphoma, B-Cell 5Leukemia, Myeloid, Acute 5Lymphoma, Non-Hodgkin 4Lymphoma, Mantle-Cell 4Lymphoma, Follicular 4Leukemia, Lymphocytic, Chronic, B-Cell 4Glioblastoma 4Prostatic Neoplasms 3Multiple Myeloma 3Burkitt Lymphoma 3Triple Negative Breast Neoplasms 2Sarcoma, Synovial 2Ovarian Neoplasms 2Lymphoma, B-Cell, Marginal Zone 2Lymphoma 2Fallopian Tube Neoplasms 2Astrocytoma 2Osteosarcoma 1Neuroblastoma 1Neoplasm Metastasis 1Melanoma 1Lymphoma, T-Cell 1Lymphoma, Large-Cell, Anaplastic 1Liposarcoma, Myxoid 1Leukemia, Prolymphocytic, B-Cell 1Leukemia, Lymphoid 1Leukemia, B-Cell 1Leukemia 1

Interventions

Temozolomide 99Radiotherapy 51Magnetic Resonance Spectroscopy 38Radiation 28Specimen Handling 25pembrolizumab 23Bevacizumab 20Lomustine 16Nivolumab 14Surgical Procedures, Operative 11Cyclophosphamide 8Biopsy 8atezolizumab 7abemaciclib 7Ipilimumab 7fludarabine 6Radiotherapy, Intensity-Modulated 6Carboplatin 6olaparib 5Metformin 5Diet, Ketogenic 5Dianhydrogalactitol 5Aminolevulinic Acid 5regorafenib 4poly ICLC 4Radiosurgery 4Photons 4Leukapheresis 4Immunoglobulin G 4Etoposide 4

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Glioblastoma × Leukapheresis × 1 year × Clear all
NCT07544992 2026-05-06

Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

City of Hope Medical Center

Phase 1 Recruiting
24 enrolled
CNS

Astrocytoma, Glioblastoma

NCT06186401 2026-03-16

Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells

University of California, San Francisco

Phase 1 Recruiting
20 enrolled
CNS

Glioblastoma

NCT03389230 2026-02-04

Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma

City of Hope Medical Center

Phase 1 Active not recruiting
29 enrolled
CNS

Glioblastoma, Glioma

NCT06815029 2025-06-26

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

City of Hope Medical Center

Phase 1 Recruiting
27 enrolled
CNSLymphoid

Astrocytoma, Glioblastoma, Lymphoma, Follicular

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