Announcements Trials
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Phase

Phase 1/2 3Phase 1 2Phase 2 1

Status

Completed 4Terminated 2

Sponsor Class

NIH 7OTHER 6

Study Type

Interventional 6

Sponsor

Cancer Type

CNS 6Sarcoma 1

Conditions

Lymphoma 17Leukemia, Myeloid, Acute 16Breast Neoplasms 15Precursor Cell Lymphoblastic Leukemia-Lymphoma 14Multiple Myeloma 12Lymphoma, Large B-Cell, Diffuse 12Lymphoma, Non-Hodgkin 11Carcinoma, Non-Small-Cell Lung 11Lymphoma, Mantle-Cell 10Leukemia 10Lymphoma, Follicular 9Hodgkin Disease 9Myelodysplastic Syndromes 8Recurrence 7Neuroblastoma 7Neoplasm Metastasis 7Leukemia, Lymphocytic, Chronic, B-Cell 7Brain Neoplasms 7Neoplasms, Plasma Cell 6Lymphoma, B-Cell, Marginal Zone 6Lung Neoplasms 6Glioblastoma 6Prostatic Neoplasms 5Pancreatic Neoplasms 5Lymphoma, T-Cell, Cutaneous 5Lymphoma, T-Cell 5Lymphoma, Large-Cell, Anaplastic 5Lymphoma, B-Cell 5Immunoblastic Lymphadenopathy 5Burkitt Lymphoma 5

Interventions

Temozolomide 264Radiotherapy 119Bevacizumab 105Magnetic Resonance Spectroscopy 59Radiation 47pembrolizumab 30Irinotecan 28Surgical Procedures, Operative 23Lomustine 21Specimen Handling 19Nivolumab 19Radiosurgery 18Carmustine 18Aminolevulinic Acid 16Erlotinib Hydrochloride 15Drug Therapy 15Blood Specimen Collection 14Radiotherapy, Intensity-Modulated 13O(6)-benzylguanine 13Chemotherapy, Adjuvant 13Carboplatin 13Filgrastim 11Cyclophosphamide 11sargramostim 10poly ICLC 10atezolizumab 10Thalidomide 10Etoposide 10Ipilimumab 9Everolimus 9

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
OTHER × Glioblastoma × Vorinostat × Clear all
NCT03426891 2025-10-06

Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

H. Lee Moffitt Cancer Center and Research Institute

Phase 1 Completed
21 enrolled 12 charts
CNS

Brain Neoplasms, Glioblastoma

NCT00555399 2024-08-22

Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme (GBM)

M.D. Anderson Cancer Center

Phase 1/2 Terminated
55 enrolled 19 charts
CNS

Glioblastoma

NCT01110876 2021-08-25

Phase I / II Vorinostat, Erlotinib and Temozolomide for Recurrent Glioblastoma Multiforme (GBM)

M.D. Anderson Cancer Center

Phase 1/2 Terminated
21 enrolled 8 charts
CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT01738646 2017-03-06

Ph II SAHA and Bevacizumab for Recurrent Malignant Glioma Patients

Duke University

Phase 2 Completed
48 enrolled 10 charts
CNS

Brain Neoplasms, Glioblastoma, Glioma

NCT00762255 2013-07-25

A Phase I Trial of Vorinostat in Combination With Bevacizumab & Irinotecan in Recurrent Glioblastoma

H. Lee Moffitt Cancer Center and Research Institute

Phase 1 Completed
19 enrolled
CNS

Glioblastoma, Neurologic Manifestations

NCT00939991 2013-06-24

Suberoylanilide Hydroxamic Acid (SAHA), Bevacizumab, Daily Temozolomide for Recurrent Malignant Gliomas

Duke University

Phase 1/2 Completed
48 enrolled 12 charts
CNS

Brain Neoplasms, Glioblastoma

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