Clinical Trials Browser

Glioma

NCT06666712 2026-04-15

TPT CED rHGG

Phase 1 Recruiting

6 enrolled

CNSLymphoid

Brain Neoplasms, Glioma, Lymphoma, Follicular

NCT00268385 2026-04-13

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Phase 1 Active not recruiting

83 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02359565 2026-04-13

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Phase 1 Active not recruiting

71 enrolled

CNSGastrointestinal

Familial ependymoma, Turcot syndrome, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Ependymoma, Glioma, Medulloblastoma

NCT02381886 2026-04-13

A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations

Phase 1 Active not recruiting

166 enrolled

CNSGastrointestinalMyeloidOther hematologic neoplasm

Astrocytoma, Glioblastoma, Glioma, Leukemia, Myelodysplastic Syndromes, Oligodendroglioma, Leukemia, Myeloid, Acute, Cholangiocarcinoma

NCT03911388 2026-04-13

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Phase 1 Recruiting

24 enrolled

CNSSarcoma

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

Clinical Trials

PuMP

TPT CED rHGG

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

Hyperpolarized Imaging in Diagnosing Participants With Glioma

A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis

Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma.

A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

PNOC020

APIC-RG

FLUVABREX

CLOVER-2

Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG

DUAL-CAR-NK-GB

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3

CILENT

A Study on the Novel Oncolytic Virus Combined With PD-1 Inhibitor in the Treatment of Recurrent High-grade Glioma

PNOC017

IMPACT

INSIGHT MRL

D2C7 for Adult Patients With Recurrent Malignant Glioma

A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG)

MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

CUE-102 in Recurrent Glioblastoma

rQNestin

Fluorescence-Guided Imaging of Brain Tumors: A Safety Study Using SBK2-ICG

Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation

Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma

Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation

Study of Orally Administered AG-881 in Patients With Advanced Solid Tumors, Including Gliomas, With an IDH1 and/or IDH2 Mutation

Study of AG-120 and AG-881 in Subjects With Low Grade Glioma

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

Phase I Trial of pH Resections of GBM at VA

Feasibility of Individualized Therapy for Recurrent Glioblastoma

Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

Study of DS-1001b in Patients With Gene IDH1-Mutated Gliomas

Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma

CARv3-TEAM-E T Cells in Glioblastoma

ACTION

FUS Etoposide for DMG