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NCT04762602 2026-03-27

A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

Phase 1 Terminated

42 enrolled 26 charts

CNSGastrointestinal

Glioma, Cholangiocarcinoma

NCT01068782 2026-02-25

Multiple Doses and Regimens of Cabozantinib in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse

Phase 2 Terminated

19 enrolled 10 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT05267106 2025-12-30

FIGHT-209

Phase 2 Terminated

83 enrolled 18 charts

Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT05429502 2025-10-10

Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Phase 1 Terminated

Glioma, Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma

NCT06270082 2025-09-19

Study of IK-595 in RAS- or RAF-altered Advanced Tumors

Phase 1 Terminated

CNSDermatologicGastrointestinalHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Pancreatic Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms

NCT03149575 2025-09-04

STAR-3

Phase 3 Terminated

Brain Neoplasms, Glioblastoma, Glioma

NCT03330197 2025-08-12

A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG

Phase 1/2 Terminated

6 enrolled 14 charts

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma

NCT06038760 2025-07-30

PEAR-GLIO

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms, Oligodendroglioma

NCT03295396 2025-07-28

ONC201 in Adults With Recurrent H3 K27M-mutant Glioma

Phase 2 Terminated

73 enrolled 13 charts 3 FDA

Glioma

NCT03690869 2025-04-08

REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma

Phase 1/2 Terminated

57 enrolled 31 charts

Diffuse Intrinsic Pontine Glioma, Glioma, Recurrence, Central Nervous System Neoplasms

NCT05737212 2025-02-21

Studying the Safety, Efficacy, and Pharmacokinetic Characteristics of BNCT in Patients With Recurrent High-grade Gliomas

Phase 1/2 Terminated

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma

NCT03416530 2025-02-14

ONC201 in Pediatric H3 K27M Gliomas

Phase 1 Terminated

134 enrolled 3 FDA

Diffuse Intrinsic Pontine Glioma, Glioma

NCT05500508 2024-12-24

Oral AMXT 1501 Dicaprate in Combination With IV DFMO

Phase 1/2 Terminated

BreastCNSDermatologicEndocrineGastrointestinalGynecologicHead & NeckOther solid neoplasmThoracic

Thyroid Cancer, Papillary, Diffuse Intrinsic Pontine Glioma, Mesothelioma, Malignant, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioma, Head and Neck Neoplasms, Melanoma, Neoplasms, Ovarian Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT04404569 2024-12-20

ETERNITI

Phase 1 Terminated

Glioblastoma, Glioma, Neoplasms

NCT04771897 2024-12-20

KONQUER

Phase 1 Terminated

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma

NCT03296696 2024-10-29

Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma

Phase 1 Terminated

30 enrolled 29 charts

Glioblastoma, Glioma

NCT04608812 2023-08-18

Convection-enhanced Delivery of OS2966 for Patients With High-grade Glioma Undergoing a Surgical Resection

Phase 1 Terminated

Astrocytoma, Glioblastoma, Glioma

NCT04541225 2023-07-14

Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors

Phase 1 Terminated

BreastCNSGenitourinary

Breast Neoplasms, Glioblastoma, Glioma, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant

NCT03332355 2023-05-24

Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 2

Phase 1 Terminated

Astrocytoma, Glioblastoma, Glioma

NCT04730349 2023-03-24

PIVOT IO 020

Phase 1/2 Terminated

15 enrolled 14 charts

CNSDermatologicLymphoidOther hematologic neoplasmSarcoma

Ependymoma, Glioma, Leukemia, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Melanoma, Neoplasms, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Leukemia, B-Cell

NCT01986348 2023-01-26

KING

Phase 2 Terminated

76 enrolled 16 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT04851834 2022-12-20

NTX-301 Monotherapy in Advanced Solid Tumours and in Combination With Platinum-based Chemotherapy in Advanced Ovarian & Bladder Cancer and in Combination With Temozolomide in High-grade Glioma

Phase 1/2 Terminated

CNSGenitourinaryGynecologic

Urinary Bladder Neoplasms, Glioma, Ovarian Neoplasms

NCT00479765 2022-06-22

A Phase 1 / 2 Dose Escalation Study of Locally-Administered OncoGel™ in Subjects With Recurrent Glioma

Phase 1/2 Terminated

4 enrolled 5 charts

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Recurrence

NCT02433392 2021-04-21

Study of Intraparenchymal Therapy as Adjunct Therapy in Patients With Recurrent, Resectable Glioblastoma Multiforme.

Phase 1 Terminated

Glioma

NCT02481960 2021-04-21

IDEB-glioma

Phase 1/2 Terminated

Glioma

NCT02029690 2020-09-25

TRAP

Phase 1 Terminated

CNSDermatologicGastrointestinal

Uveal Melanoma, Carcinoma, Glioma, Carcinoma, Hepatocellular

NCT04327011 2020-03-30

A Continuation Protocol for Patients Previously Enrolled in a Study of Toca 511

Phase 1 Terminated

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT02764151 2020-01-27

First in Patient Study for PF-06840003 in Malignant Gliomas

Phase 1 Terminated

17 enrolled 35 charts

Astrocytoma, Glioma, Oligodendroglioma

NCT01229644 2018-07-05

Study of Crenolanib, a Selective and Potent Inhibitor of PDGFR, for the Treatment of Adult Gliomas

Phase 2 Terminated

Brain Neoplasms, Glioma

NCT01898273 2015-09-09

Imaging Trial With I-124-CLR1404 in Patients With Newly Diagnosed or Recurrent Glioblastoma

Phase 2 Terminated

Disease, Glioblastoma, Glioma

NCT00761280 2014-11-14

SAPPHIRE

Phase 3 Terminated

27 enrolled 28 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Neoplasms

NCT00650949 2013-05-03

Efficacy Study of CYT997 in Combination With Carboplatin in Glioblastoma

Phase 1/2 Terminated

Glioblastoma, Glioma

NCT00389090 2012-02-09

A Phase II Study of Temozolomide and O6-Benzylguanine (O6-BG) in Patients With Temozolomide-Resistant Anaplastic Glioma

Phase 2 Terminated

Astrocytoma, Glioma, Oligodendroglioma

NCT00290771 2011-05-16

Efficacy and Safety of Imatinib Mesylate Plus Hydroxyurea (HU) in Patients With Recurrent Glioblastoma Multiforme (GBM)

Phase 2 Terminated

231 enrolled 12 charts

Glioblastoma, Glioma

NCT00826930 2010-08-12

Trans Sodium Crocetinate (TSC) Study of Intra-tumoral Oxygen Concentration, Safety, and Pharmacokinetics in Patients With High Grade Glioma

Phase 1 Terminated

Brain Neoplasms, Glioma