Clinical Trials

83 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT03911388 2026-04-13

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

24 enrolled

Phase 1 Not yet recruiting

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT07422363 2026-04-13

Testing the Combination of Anti-cancer Drugs Actimab-A and Cemiplimab (REGN2810) to Improve Outcomes for Patients With Recurrent Glioblastoma

30 enrolled

Glioblastoma, Gliosarcoma

NCT07134842 2026-04-09

WinGlio-ipi

16 enrolled

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT06934889 2026-03-30

Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

60 enrolled

Glioblastoma, Gliosarcoma

NCT03478462 2026-03-18

CLOVER-2

CNSGenitourinaryLymphoidSarcoma

30 enrolled

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioblastoma, Glioma, Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT03896568 2026-03-05

MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

36 enrolled

Astrocytoma, Glioblastoma, Glioma, Gliosarcoma

NCT04216329 2026-01-23

Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

11 enrolled 19 charts

Glioblastoma, Gliosarcoma

NCT04991870 2026-01-23

Phase I CB-NK-TGF-ßR2-/NR3C1- in rGBM

25 enrolled

Sarcoma

Gliosarcoma

NCT02709226 2025-12-31

Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Phase 1 Completed

17 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT04541082 2025-12-18

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

102 enrolled

Typical Teratoid Rhabdoid Tumor, Astrocytoma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma

NCT06806228 2025-11-19

Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard Treatment of Glioblastoma/Diffuse Midline Glioma and Response to Treatment (Regardless of Mutation Status)

Phase 1 Suspended

10 enrolled

Glioblastoma, Gliosarcoma

NCT02192359 2025-11-14

Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas

18 enrolled 16 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT03107780 2025-11-13

Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

Phase 1 Terminated

32 enrolled

Glioblastoma, Gliosarcoma

NCT04555577 2025-10-29

Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

29 enrolled

Glioblastoma, Gliosarcoma

NCT02062827 2025-10-02

M032-HSV-1

29 enrolled 16 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Virus Diseases, Gliosarcoma

NCT06614855 2025-08-06

A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma

12 enrolled

Astrocytoma, Glioblastoma, Gliosarcoma

NCT04477200 2025-06-29

Mycophenolate Mofetil Combined With Radiation Therapy in Glioblastoma

68 enrolled

Glioblastoma, Gliosarcoma

NCT03452930 2025-06-04

Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma

Phase 1 Completed

5 enrolled

Glioblastoma, Gliosarcoma

NCT01430351 2025-05-07

Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

Phase 1 Terminated

144 enrolled

Glioblastoma, Gliosarcoma

NCT02186509 2025-04-30

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

Phase 1 Completed

17 enrolled 11 charts