Clinical Trials Browser

NCT03174197 2025-09-24

Atezolizumab in Combination With Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Phase 1/2 Completed

60 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT03150862 2025-02-04

A Study Assessing Pamiparib With Radiation and/or Temozolomide (TMZ) in Participants With Newly Diagnosed or Recurrent Glioblastoma

Phase 1/2 Completed

116 enrolled 31 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Nervous System Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Gliosarcoma

NCT01837862 2024-07-05

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Phase 1/2 Completed

36 enrolled

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma, Gliosarcoma, Optic Nerve Glioma

NCT02052648 2024-03-27

Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors

Phase 1/2 Completed

160 enrolled 21 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT02661282 2023-06-18

Autologous CMV-Specific Cytotoxic T Cells and Temozolomide in Treating Patients With Glioblastoma

Phase 1/2 Completed

65 enrolled 21 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00662506 2023-06-06

Cediranib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Phase 1/2 Completed

46 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT04657315 2023-01-18

MSC11FCD-GBM

Phase 1/2 Completed

10 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Neoplasms, Germ Cell and Embryonal, Central Nervous System Neoplasms, Gliosarcoma

NCT00731731 2022-08-04

Vorinostat, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 1/2 Completed

125 enrolled 12 charts

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT01062399 2022-06-09

RTOG 0913

Phase 1/2 Completed

279 enrolled 14 charts

CNSSarcoma

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT02330562 2022-06-08

Stage 1: Marizomib + Bevacizumab in WHO Gr IV GBM; Stage 2: Marizomib Alone; Stage 3: Combination of Marizomib and Bevacizumab

Phase 1/2 Completed

121 enrolled 27 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT01189266 2021-10-28

Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Phase 1/2 Completed

79 enrolled 17 charts

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Gliosarcoma

NCT01051557 2021-07-19

Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma

Phase 1/2 Completed

36 enrolled 15 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00052208 2020-10-30

Gefitinib and Radiation Therapy in Treating Patients With Glioblastoma Multiforme

Phase 1/2 Completed

158 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT00402116 2020-08-06

Phase 1/2 Study of Enzastaurin in Newly Diagnosed Glioblastoma Multiforme (GBM) and Gliosarcoma (GS) Patients

Phase 1/2 Completed

72 enrolled 19 charts

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT00047073 2020-08-03

Sirolimus in Treating Patients With Glioblastoma Multiforme

Phase 1/2 Completed

13 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00553150 2020-02-13

Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Phase 1/2 Completed

122 enrolled 11 charts

CNSSarcoma

Astrocytoma, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00869401 2020-02-13

Dasatinib or Placebo, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 1/2 Completed

217 enrolled 12 charts

CNSSarcoma

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01806675 2019-10-03

18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

Phase 1/2 Completed

25 enrolled 14 charts

BreastCNSGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Glioblastoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms, Esthesioneuroblastoma, Olfactory, Gliosarcoma, Breast Neoplasms, Male

NCT01454596 2019-08-21

CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII

Phase 1/2 Completed

18 enrolled 25 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT01514201 2019-08-13

Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas

Phase 1/2 Completed

66 enrolled 24 charts

CNSSarcoma

Astrocytoma, Glioblastoma, Gliosarcoma

NCT00486603 2019-07-10

Hydroxychloroquine, Radiation, and Temozolomide Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 1/2 Completed

92 enrolled 18 charts

CNSSarcoma

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00404248 2019-03-06

Tetra-O-Methyl Nordihydroguaiaretic Acid in Treating Patients With Recurrent High-Grade Glioma

Phase 1/2 Completed

35 enrolled 13 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00441142 2019-03-05

Zactima

Phase 1/2 Completed

119 enrolled 15 charts

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT01977677 2018-10-23

Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma

Phase 1/2 Completed

30 enrolled 11 charts

CNSSarcoma

Glioblastoma, Glioma, Medulloblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Gliosarcoma

NCT00329719 2018-10-16

Sorafenib Tosylate and Temsirolimus in Treating Patients With Recurrent Glioblastoma

Phase 1/2 Completed

115 enrolled 13 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00335764 2018-07-02

Sorafenib Combined With Erlotinib, Tipifarnib, or Temsirolimus in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

Phase 1/2 Completed

92 enrolled 24 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00004868 2018-06-27

SU5416 in Treating Patients With Recurrent Astrocytoma or Mixed Glioma That Has Not Responded to Radiation Therapy

Phase 1/2 Completed

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Meningioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00010049 2018-06-27

Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma

Phase 1/2 Completed

105 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Meningioma, Oligodendroglioma, Central Nervous System Neoplasms, Glioma, Subependymal, Gliosarcoma

NCT00005859 2018-06-26

Tipifarnib in Treating Patients With Recurrent or Progressive Malignant Glioma

Phase 1/2 Completed

136 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00022724 2018-06-26

CCI-779 in Treating Patients With Malignant Glioma

Phase 1/2 Completed

49 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT01648348 2018-05-23

Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme

Phase 1/2 Completed

116 enrolled 17 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00305864 2018-03-05

Motexafin Gadolinium, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

Phase 1/2 Completed

118 enrolled 10 charts

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT00045708 2017-10-18

A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas

Phase 1/2 Completed

57 enrolled 18 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00045110 2017-08-17

Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma

Phase 1/2 Completed

136 enrolled 27 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Meningioma, Oligodendroglioma, Gliosarcoma

NCT01026493 2017-07-02

Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma

Phase 1/2 Completed

257 enrolled 16 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00379080 2017-04-07

Tandutinib in Treating Patients With Recurrent or Progressive Glioblastoma

Phase 1/2 Completed

60 enrolled 22 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00085540 2017-01-02

FR901228 in Treating Patients With Recurrent High-Grade Gliomas

Phase 1/2 Completed

50 enrolled 6 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT00027612 2016-12-07

Irinotecan Plus Radiation Therapy Followed By Chemotherapy in Treating Patients With Glioblastoma Multiforme

Phase 1/2 Completed

58 enrolled

CNSSarcoma

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00085254 2016-02-25

Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 1/2 Completed

112 enrolled 14 charts

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT00085566 2016-01-20

Everolimus and Gefitinib in Treating Patients With Progressive Glioblastoma Multiforme or Progressive Metastatic Prostate Cancer

Phase 1/2 Completed

61 enrolled 8 charts

CNSGenitourinarySarcoma

Brain Neoplasms, Glioblastoma, Prostatic Neoplasms, Central Nervous System Neoplasms, Gliosarcoma

NCT00124657 2015-12-04

Erlotinib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Glioma

Phase 1/2 Completed

62 enrolled 15 charts

CNSSarcoma

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Gliosarcoma

NCT00003417 2015-11-17

Computer Planned Radiation Therapy Plus Chemotherapy in Treating Patients With Glioblastoma Multiforme

Phase 1/2 Completed

40 enrolled

CNSSarcoma

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00112736 2015-06-15

Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma

Phase 1/2 Completed

69 enrolled 12 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00003461 2014-08-21

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors

Phase 1/2 Completed

CNSSarcoma

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00002752 2014-07-16

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers

Phase 1/2 Completed

CNSSarcoma

Familial ependymoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Oligodendroglioma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT00099060 2014-01-27