Clinical Trials Browser

Phase 2 × NIH × Gliosarcoma × Clear all

NCT04817254 2026-04-17

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Phase 2 Completed

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT01931098 2025-08-11

Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab

Phase 2 Completed

35 enrolled 13 charts

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01062425 2022-07-26

Temozolomide and Radiation Therapy With or Without Cediranib Maleate in Treating Patients With Newly Diagnosed Glioblastoma

Phase 2 Completed

261 enrolled 10 charts

Glioblastoma, Gliosarcoma

NCT01609790 2022-07-21

Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors

Phase 2 Completed

137 enrolled 13 charts

Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT03641326 2022-04-19

Sunitinib in Sarcomas of the Central Nervous System

Phase 2 Terminated

5 enrolled 14 charts

Brain Neoplasms, Gliosarcoma

NCT00423735 2019-07-24

Dasatinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

Phase 2 Completed

64 enrolled 12 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00902577 2019-04-08

MRI and PET/FMISO In Assessing Tumor Hypoxia in Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 2 Completed

50 enrolled 16 charts

Glioblastoma, Gliosarcoma

NCT00433381 2018-09-17

Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma

Phase 2 Completed

123 enrolled 16 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00107003 2018-07-05

GW572016 to Treat Recurrent Malignant Brain Tumors

Phase 2 Completed

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Gliosarcoma

NCT00980343 2017-08-16

GDC-0449 in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

Phase 2 Completed

44 enrolled 11 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00540722 2017-08-11

Gossypol in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

Phase 2 Completed

56 enrolled 9 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00112866 2017-06-14

Cilengitide in Treating Patients Who Are Undergoing Surgery for Recurrent or Progressive Glioblastoma Multiforme

Phase 2 Terminated

30 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01122901 2017-05-03

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma

Phase 2 Terminated

47 enrolled 9 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00436436 2017-03-28

O(6)-Benzylguanine and Temozolomide in Treating Patients With Glioblastoma Multiforme That Did Not Respond to Previous Temozolomide and Radiation Therapy

Phase 2 Terminated

12 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00459381 2017-03-15

Pazopanib in Treating Patients With Recurrent Glioblastoma

Phase 2 Completed

35 enrolled 12 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00445588 2016-04-27

Erlotinib and Sorafenib in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

Phase 2 Completed

56 enrolled 6 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00995007 2016-03-29

A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas

Phase 2 Completed

112 enrolled 12 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma, Disease Progression

NCT00499473 2016-02-29

Sunitinib in Treating Patients With Recurrent Malignant Gliomas

Phase 2 Completed

31 enrolled 6 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00667394 2015-11-05

Tandutinib Plus Bevacizumab to Treat Recurrent Brain Tumors

Phase 2 Completed

42 enrolled 11 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00369590 2015-10-02

VEGF Trap in Treating Patients With Recurrent Malignant Gliomas That Did Not Respond to Temozolomide

Phase 2 Completed

58 enrolled 12 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT00004146 2015-05-08

Carboxyamidotriazole + RT in Treating Patients Newly Diagnosed Supratentorial GBM

Phase 2 Completed

55 enrolled 10 charts

Glioblastoma, Gliosarcoma

NCT00238303 2014-05-23

Vorinostat in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

Phase 2 Completed

103 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00641706 2014-05-14

Vorinostat and Bortezomib in Treating Patients With Progressive, Recurrent Glioblastoma Multiforme

Phase 2 Completed

44 enrolled 9 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00054496 2014-01-10

Erlotinib in Treating Patients With Recurrent or Progressive Glioblastoma Multiforme

Phase 2 Unknown

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00492687 2014-01-10

Radiation Therapy, Temozolomide, Tamoxifen, and Carboplatin in Treating Patients With Malignant Gliomas

Phase 2 Unknown

Astrocytoma, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00003185 2013-12-04

Biological Therapy in Treating Patients With Glioblastoma Multiforme

Phase 2 Completed

Astrocytoma, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00006656 2013-11-06

Carmustine in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

Phase 2 Unknown

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00305656 2013-08-22

AZD2171 in Treating Patients With Recurrent Glioblastoma Multiforme

Phase 2 Completed

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00039494 2013-08-02

Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors

Phase 2 Completed

Glioblastoma, Gliosarcoma

NCT00014677 2013-07-18

NBI-3001 Followed by Surgery in Treating Patients With Recurrent Glioblastoma Multiforme

Phase 2 Completed

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00016328 2013-07-18

CCI-779 in Treating Patients With Recurrent Glioblastoma Multiforme

Phase 2 Completed

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00014170 2013-07-16

Gefitinib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 2 Completed

Glioblastoma, Gliosarcoma

NCT00002608 2013-07-10

Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors

Phase 2 Completed

CNSEndocrineGastrointestinalHead & NeckOther solid neoplasmSarcomaThoracic

Familial ependymoma, Thyroid Cancer, Papillary, Mesothelioma, Malignant, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms, Medulloblastoma, Oligodendroglioma, Pheochromocytoma, Sarcoma, Thyroid Neoplasms, Central Nervous System Neoplasms, Adenocarcinoma, Follicular, Adrenocortical Carcinoma, Carcinoma, Medullary, Glioma, Subependymal, Gliosarcoma, Optic Nerve Glioma, Thyroid Carcinoma, Anaplastic

NCT00002639 2013-06-21

Suramin in Treating Patients With Recurrent Primary Brain Tumors

Phase 2 Completed

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00003574 2013-06-21

Radiation Therapy in Treating Patients With Progressive or Recurrent Malignant Brain Tumors

Phase 2 Completed

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00005976 2013-06-03

Pyrazoloacridine Plus Carboplatin in Treating Patients With Recurrent Glioma

Phase 2 Completed

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00058097 2013-04-09

Tipifarnib and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 2 Completed

Glioblastoma, Gliosarcoma

NCT00008008 2013-02-04

Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Malignant Glioma

Phase 2 Completed

Familial ependymoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00075491 2013-01-24

Neoadjuvant and Adjuvant Fenretinide Compared With Adjuvant Fenretinide Alone in Treating Patients Who Are Undergoing Surgical Resection For Recurrent Glioblastoma Multiforme

Phase 2 Terminated

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00064363 2012-03-08

Talampanel in Treating Patients With Recurrent High-Grade Glioma

Phase 2 Completed

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00003067 2009-02-09

Biological Therapy in Treating Patients With Primary or Advanced Glioma

Phase 2 Suspended

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00004017 2009-02-09

Radiolabeled Monoclonal Antibody in Treating Patients With Glioblastoma Multiforme or Anaplastic Astrocytoma

Phase 2 Completed

Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma