Announcements Trials
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Phase

Phase 3 4Phase 2 1

Status

Completed 3Terminated 2

Sponsor Class

OTHER 6INDUSTRY 5

Study Type

Interventional 5

Sponsor

Cancer Type

Head & Neck 5

Conditions

Carcinoma, Non-Small-Cell Lung 38Neoplasms 19Breast Neoplasms 9Head and Neck Neoplasms 5Colorectal Neoplasms 3Neoplasm Metastasis 2Carcinoma, Squamous Cell 2Adenocarcinoma 2Urologic Neoplasms 1Stomach Neoplasms 1Squamous Non-small Cell Lung Cancer 1Solid Tumors 1Rhabdomyosarcoma 1Prostatic Neoplasms 1Pancreatic Neoplasms 1Neuroectodermal Tumors 1NSCLC Harboring NRG1 Fusion 1Lung Neoplasms 1Glioma 1Glioblastoma 1Colonic Neoplasms 1Advanced Solid Tumors 1

Interventions

pembrolizumab 72Cisplatin 57Cetuximab 38Fluorouracil 25Nivolumab 21Radiotherapy 20Carboplatin 19Paclitaxel 14Docetaxel 11Cyclophosphamide 9Gefitinib 8fludarabine 7durvalumab 7zalutumumab 6atezolizumab 6Drug Therapy 6Bleomycin 6epacadostat 5cemiplimab 5Radiotherapy, Intensity-Modulated 5Pemetrexed 5Ipilimumab 5Gemcitabine 5Afatinib 5spartalizumab 4Standard of Care 4Radiation 4Injections 4Immune Checkpoint Inhibitors 4Fibroblast Growth Factor 7 4

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
INDUSTRY × Head and Neck Neoplasms × Afatinib × Clear all
NCT01856478 2026-01-12

LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy

Boehringer Ingelheim

Phase 3 Completed
340 enrolled 23 charts
Head & Neck

Head and Neck Neoplasms

NCT02131155 2019-03-01

LUX-Head & Neck 4: Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy

Boehringer Ingelheim

Phase 3 Terminated
36 enrolled 6 charts
Head & Neck

Head and Neck Neoplasms

NCT01345682 2018-02-15

LUX-Head&Neck 1: A Phase III Trial of Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy

Boehringer Ingelheim

Phase 3 Completed
483 enrolled 21 charts
Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT01345669 2017-12-07

LUX-Head&Neck 2: A Phase III Trial of Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy

Boehringer Ingelheim

Phase 3 Terminated
617 enrolled 13 charts
Head & Neck

Head and Neck Neoplasms

NCT00514943 2016-07-26

BIBW 2992 (Afatinib) in Head & Neck Cancer

Boehringer Ingelheim

Phase 2 Completed
124 enrolled 31 charts
Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms

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