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Phase

Phase 1/2 2Phase NA 1Phase EARLY_PHASE1 1Phase 1 1

Status

Completed 3Terminated 1Recruiting 1

Sponsor Class

OTHER 4INDUSTRY 1

Study Type

Interventional 5

Sponsor

Cancer Type

Head & Neck 5Gynecologic 1Breast 1

Conditions

Polycystic Ovary Syndrome 149Breast Neoplasms 38Prostatic Neoplasms 31Insulin Resistance 30Obesity 23Endometrial Neoplasms 15Neoplasms 14Infertility 14Colorectal Neoplasms 13Pancreatic Neoplasms 12Carcinoma, Non-Small-Cell Lung 12Anovulation 10Lung Neoplasms 9Neoplasm Metastasis 8Hyperandrogenism 8Glioblastoma 8Diabetes Mellitus 8Squamous Cell Carcinoma of Head and Neck 7Metabolic Syndrome 7Melanoma 7Precursor Cell Lymphoblastic Leukemia-Lymphoma 5Ovarian Neoplasms 5Lymphoma, Large B-Cell, Diffuse 5Head and Neck Neoplasms 5Brain Neoplasms 5Adenocarcinoma 5Weight Loss 4Uterine Cervical Neoplasms 4Urinary Bladder Neoplasms 4Rectal Neoplasms 4

Interventions

Cisplatin 252Radiotherapy 176Cetuximab 144pembrolizumab 120Docetaxel 96Fluorouracil 92Carboplatin 80Paclitaxel 77Radiotherapy, Intensity-Modulated 69Nivolumab 37Radiation 30Drug Therapy 30Erlotinib Hydrochloride 26Gemcitabine 25Gefitinib 21Cyclophosphamide 21Surveys and Questionnaires 20Surgical Procedures, Operative 19Standard of Care 19Pemetrexed 19durvalumab 18Magnetic Resonance Spectroscopy 17Capecitabine 17Radiosurgery 16Celecoxib 16atezolizumab 15Filgrastim 15Amifostine 15Low-Level Light Therapy 14Everolimus 14

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Interventional × Head and Neck Neoplasms × Metformin × Clear all
NCT05768139 2026-05-22

PIKALO-1

Eli Lilly and Company

Phase 1/2 Recruiting
880 enrolled
BreastGynecologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Breast Diseases, Breast Neoplasms, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Neoplasms, Neoplasms by Site, Hereditary Sensory and Autonomic Neuropathies, Ovarian Neoplasms, Endometrial Neoplasms

NCT02949700 2023-06-29

Phase I/II Study OF Metformin in Combination With Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma

Baylor College of Medicine

Phase 1/2 Completed
26 enrolled 14 charts
Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03510390 2021-11-18

HEAD-MET

Insel Gruppe AG, University Hospital Bern

Phase NA Completed
17 enrolled
Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02325401 2020-06-11

Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

University of Cincinnati

Phase 1 Completed
20 enrolled 11 charts
Head & Neck

Head and Neck Neoplasms

NCT02402348 2017-02-08

Pilot Study of Metformin in HNSCC to Investigate the Effects of MF, Tumor Genotype and MF-genotype Interactions, on Tumor Metabolism and Anoikis

West Virginia University

Phase EARLY_PHASE1 Terminated
3 enrolled
Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

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