Clinical Trials

252 enrolled

Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT02568267 2026-05-27

STARTRK-2

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

534 enrolled 1 FDA

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT06998342 2026-05-26

MOHSAHRTSS

24 enrolled

Head and Neck Neoplasms

NCT03646461 2026-05-22

Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC

Phase 2 Terminated

5 enrolled 9 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04169074 2026-05-22

Immune Modulation by Abemaciclib in Head and Neck Squamous Cell Carcinoma (HNSCC). (AIM Trial)

Phase 2 Terminated

7 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT04858269 2026-05-22

First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients

32 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT04915183 2026-05-22

Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer

224 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hearing Loss

NCT06062420 2026-05-22

A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202

316 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07601737 2026-05-22

Nimotuzumab Combined With PD-1 Inhibitors and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

182 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03494322 2026-05-20

EACH

16 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT06172478 2026-05-15

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

740 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Endometrial Neoplasms

NCT07589049 2026-05-15

GATEWAY

42 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02841748 2026-05-13

A Randomized, Double-Blind Phase II Study of Adjuvant Pembrolizumab Versus Placebo in Head and Neck Cancers at High Risk for Recurrence- the PATHWay Study

100 enrolled 13 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05420948 2026-05-12

A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07149207 2026-05-12

Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors

30 enrolled

Margins of Excision, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms

NCT04373642 2026-05-11

QUADSHOT

30 enrolled

Head and Neck Neoplasms

NCT06997068 2026-05-11

Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population

25 enrolled

Carcinoma, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT02296684 2026-05-08

Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma

67 enrolled 15 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06660017 2026-05-08

Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse

62 enrolled

Head and Neck Neoplasms

NCT07484139 2026-05-08

NEO COMBAT XL

26 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04313504 2026-05-07

Study Evaluating the Efficacy of Niraparib and Dostarlimab (TSR-042) in Recurrent/Metastatic HNSCC

10 enrolled 9 charts

Head and Neck Neoplasms

NCT03355560 2026-05-06

Adjuvant Nivolumab After Salvage Resection in Head and Neck Cancer Patients Previously Treated With Definitive Therapy

39 enrolled 11 charts

Head and Neck Neoplasms

NCT07058805 2026-05-06

COMPORT

50 enrolled

Phase 2 Enrolling by invitation

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07062354 2026-05-06

CAPT-HN

50 enrolled

Head and Neck Neoplasms

NCT02270814 2026-05-05

CACTUX

74 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02641093 2026-05-04

Phase II Trial of Adjuvant Cisplatin and Radiation With Pembrolizumab in Resected Head and Neck Squamous Cell Carcinoma

96 enrolled 12 charts

Head and Neck Neoplasms

NCT07524894 2026-05-01

SNIFF

126 enrolled

Head and Neck Neoplasms

NCT05358548 2026-04-30

ATATcH Alternating Treatment Plans for Advanced Cancer

150 enrolled

Head & NeckThoracic

Head and Neck Neoplasms, Lung Neoplasms

NCT03818061 2026-04-24

ATHENA

33 enrolled

Head and Neck Neoplasms

NCT07209189 2026-04-23

(NeoScorch HN)

75 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT03485209 2026-04-20

innovaTV 207

GastrointestinalHead & NeckThoracic

350 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT06477692 2026-04-17

Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy

80 enrolled

Head and Neck Neoplasms

NCT07361133 2026-04-16

Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer

120 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasm Metastasis, Recurrence

NCT00076310 2026-04-15

OSI-774/Cisplatin/Taxotere in Head & Neck Squamous Cell Cancer

50 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT04003051 2026-04-15

Web-Based Program in Helping Patients With Head and Neck Cancer Adhere to Swallowing Exercises and Coping Strategies

300 enrolled

Head and Neck Neoplasms, Trismus

NCT04704453 2026-04-14

TEC-ORL

13 enrolled

Head and Neck Neoplasms, Neuralgia

NCT05576974 2026-04-14

A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)

120 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Unknown Primary

NCT04225117 2026-04-13

A Study to Evaluate Enfortumab Vedotin in Subjects With Locally Advanced or Metastatic Malignant Solid Tumors (EV-202)

BreastGastrointestinalHead & NeckThoracic

329 enrolled 23 charts

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Triple Negative Breast Neoplasms

NCT04938609 2026-04-09

Neoadjuvant Immunoradiotherapy in Head & Neck Cancer (NIRT 2-HNC)

28 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06003231 2026-04-07

A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2

GynecologicHead & NeckThoracic

120 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms

NCT07040969 2026-04-07

Spirulina-Derived Product Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors

70 enrolled

Head and Neck Neoplasms

NCT05318027 2026-04-01

ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy

GastrointestinalHead & NeckThoracic

70 enrolled

Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms

NCT06137274 2026-04-01

Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

35 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT05980000 2026-03-31

Rambro2

37 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05287113 2026-03-27

Study of Retinfanlimab in Combination With INCAGN02385 and INCAGN02390 as First-Line Treatment in Participants With PD-L1-Positive (CPS ≥ 1) Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

176 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03217188 2026-03-23

Proton Re-Irradiation for Recurrent Head and Neck Cancer

87 enrolled

Head and Neck Neoplasms

NCT04883281 2026-03-18

DARTBOARD

50 enrolled

Head and Neck Neoplasms

NCT01612351 2026-03-17

Multimodality Risk Adapted Tx Including Induction Chemo for SCCHN Amenable to Transoral Surgery

40 enrolled 20 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT02528955 2026-03-17

DIREKHT

200 enrolled

Head and Neck Neoplasms

NCT02439034 2026-03-16

KETOCOL