Clinical Trials Browser

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT04779151 2025-12-01

NIRADO

Phase 2 Terminated

51 enrolled

GastrointestinalGenitourinaryHead & Neck

Biliary Tract Neoplasms, Carcinoma, Renal Cell, Head and Neck Neoplasms

NCT05169437 2025-10-29

PAVO

Phase 2 Terminated

22 enrolled 17 charts

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Pancreatic Neoplasms, Urologic Neoplasms, Endometrial Neoplasms

NCT05980598 2025-08-01

BelieveIT-201

Phase 2 Terminated

27 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05101798 2025-07-28

The Role of 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Cancers: a Pilot Trial

Phase 2 Terminated

7 enrolled 5 charts

Head & Neck

Head and Neck Neoplasms, Neoplasms, Skull Base Neoplasms

NCT04633278 2025-05-11

CMP-001 in Combination With Pembrolizumab in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Phase 2 Terminated

24 enrolled 18 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Head and Neck Neoplasms

NCT00358007 2025-05-04

Use of Cone Beam Kilovoltage Imaging in Patients Receiving Radiation Therapy for Head and Neck Cancer

Phase 2 Terminated

30 enrolled 10 charts

Head & Neck

Head and Neck Neoplasms

NCT04383210 2025-04-03

Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors

Phase 2 Terminated

54 enrolled 11 charts

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Fibromatosis, Gingival, 2, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Uterine Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT05265013 2024-11-04

ASP-1929 Photoimmunotherapy Combined With Pembrolizumab in Patients With Recurrent Head and Neck Cancer, With or Without Metastases

Phase 2 Terminated

16 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03207867 2024-10-09

A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma

Phase 2 Terminated

315 enrolled 73 charts

BreastDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Melanoma, Pancreatic Neoplasms, Spinocerebellar Degenerations, Triple Negative Breast Neoplasms

NCT01284348 2024-08-29

To Determine Safe and Effective Dose of Sotatercept for the Treatment of Chemotherapy Induced Anemia in Participants With Advanced Non-small Cell Lung Cancer

Phase 2 Terminated

26 enrolled 18 charts

Classical hematologyGenitourinaryGynecologicHead & NeckThoracic

Anemia, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Small Cell Lung Carcinoma

NCT04936841 2024-04-04

Bempegaldesleukin (NKTR-214) With Radiation and Anti-PD-1 Immunotherapy for Head and Neck Squamous Cell Carcinoma

Phase 2 Terminated

5 enrolled 17 charts

Head & Neck

Head and Neck Neoplasms

NCT04634825 2023-12-20

Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer

Phase 2 Terminated

62 enrolled 24 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04644315 2023-08-07

ALpha-T

Phase 2 Terminated

1 enrolled 5 charts

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Renal Cell, Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Melanoma, Neoplasms, Neoplasms by Site, Ovarian Neoplasms, Pancreatic Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Salivary Gland Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT03020823 2023-06-05

To Evaluate the Efficacy and Safety of SCB01A in Subjects With r/m Squamous Cell Head and Neck Cancer

Phase 2 Terminated

10 enrolled 10 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03642990 2023-04-12

NR in Chemo-induced Peripheral Neuropathy

Phase 2 Terminated

5 enrolled 11 charts

GynecologicHead & Neck

Head and Neck Neoplasms, Endometrial Neoplasms

NCT03193931 2023-02-06

ELDORANDO

Phase 2 Terminated

47 enrolled

Head & Neck

Head and Neck Neoplasms

NCT02055963 2022-10-20

Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer

Phase 2 Terminated

30 enrolled 9 charts

Head & Neck

cyclopia sequence, Head and Neck Neoplasms

NCT00394147 2022-08-05

Pemetrexed and Gemcitabine in Patients With Advanced Head and Neck Cancer

Phase 2 Terminated

17 enrolled 8 charts

Head & Neck

Head and Neck Neoplasms, Neoplasms

NCT04880603 2022-05-13

Utility of Restrata With Split-thickness Skin Graft to Reconstruct the Forearm Donor Site

Phase 2 Terminated

5 enrolled

Head & Neck

Head and Neck Neoplasms

NCT01606566 2022-02-18

A Study to Evaluate the Safety and Efficacy of Amphinex Induced PCI of Bleomycin for Recurrent Head and Neck Cancer.

Phase 2 Terminated

26 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasms, Recurrence

NCT00003777 2022-01-26

Surgery, Radiation Therapy, and Combination Chemotherapy in Treating Patients With Recurrent Head and Neck Cancer

Phase 2 Terminated

35 enrolled

Head & Neck

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03937141 2022-01-03

Efficacy and Safety Trial of ADU-S100 and Pembrolizumab in Head and Neck Cancer

Phase 2 Terminated

16 enrolled 9 charts

Head & Neck

Head and Neck Neoplasms

NCT00566540 2021-11-26

Ph 2 Intensification Regimen for Previously Untreated, Resectable, Advanced Squamous Cell Cancer

Phase 2 Terminated

11 enrolled 8 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03938337 2021-07-09

Abemaciclib and Pembrolizumab in Metastatic or Recurrent Head and Neck Cancer

Phase 2 Terminated

1 enrolled 4 charts

Head & Neck

Head and Neck Neoplasms

NCT01403064 2021-05-11

Safety and Efficacy of ALD518 for Reducing Oral Mucositis in Head and Neck Cancer Subjects

Phase 2 Terminated

76 enrolled 25 charts

Head & Neck

Head and Neck Neoplasms, Stomatitis

NCT00904345 2021-02-24

Study of Radiation (RT) Concurrent With Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (SCC)

Phase 2 Terminated

23 enrolled 18 charts

Head & Neck

Head and Neck Neoplasms

NCT03887442 2021-01-07

EXTAX

Phase 2 Terminated

17 enrolled 8 charts

Head & Neck

Head and Neck Neoplasms, Neoplasm Metastasis, Recurrence

NCT01133678 2020-05-08

Study in Locally Advanced Squamous Cell Carcinoma of Head and Neck

Phase 2 Terminated

50 enrolled 9 charts

Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT01111058 2020-04-07

Everolimus Versus Placebo in Head and Neck Cancer

Phase 2 Terminated

52 enrolled 13 charts

Head & Neck

Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT03463161 2020-01-27

ORKA

Phase 2 Terminated

2 enrolled 5 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02485470 2019-10-09

Benefits of MPACT in Locally Advanced Head and Neck Cancer Patients Undergoing Chemoradiotherapy

Phase 2 Terminated

5 enrolled

Head & Neck

Head and Neck Neoplasms

NCT02410382 2019-05-14

Dexamethasone for Treatment of Radiation-related Fatigue in Patients Receiving RT for Head-neck and Lung Cancer

Phase 2 Terminated

79 enrolled

Head & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Neoplasms

NCT00750555 2019-02-26

Maintenance of Tarceva (Erlotinib) in Patients With Locally Advanced Head and Neck Cancer

Phase 2 Terminated

4 enrolled

Head & Neck

Head and Neck Neoplasms

NCT02633800 2019-01-07

Patritumab With Cetuximab and a Platinum Agent for Squamous Cell Carcinoma (Cancer) of the Head and Neck (SCCHN )

Phase 2 Terminated

87 enrolled 13 charts

Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasms by Site

NCT00100828 2018-12-06

Irinotecan in Treating Patients With Metastatic or Inoperable Thyroid Cancer

Phase 2 Terminated

6 enrolled 4 charts

Head & Neck

Head and Neck Neoplasms, Thyroid Neoplasms, Carcinoma, Medullary

NCT00646659 2018-07-09

Cetuximab, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer That Cannot Be Removed By Surgery

Phase 2 Terminated

47 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00256308 2018-05-01

Adjuvant Chemoradiation With Weekly Oxaliplatin in Resected Head and Neck Cancer

Phase 2 Terminated

6 enrolled 11 charts

Head & Neck

Head and Neck Neoplasms

NCT01216020 2018-01-17

CTXMAB+RT

Phase 2 Terminated

70 enrolled

Head & Neck

Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Pharyngeal Neoplasms

NCT00319839 2018-01-12

Study of Albumin Bound-Paclitaxel for Treatment of Recurrent or Metastatic Head and Neck Cancer With Cetuximab

Phase 2 Terminated

10 enrolled 8 charts

Head & Neck

Head and Neck Neoplasms

NCT00352118 2017-12-28

Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer

Phase 2 Terminated

4 enrolled 4 charts

Head & NeckOther

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Xerostomia, Mucositis

NCT00003489 2017-11-21

Antineoplaston Therapy in Treating Patients With Advanced Head and Neck Cancer

Phase 2 Terminated

7 enrolled

Head & Neck

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Paranasal Sinus Neoplasms, Salivary Gland Neoplasms

NCT00503776 2017-06-20

Chemo/XRT +/- Amifostine to Assess Outcomes Related to Xerostomia, Mucositis, & Dysphagia

Phase 2 Terminated

41 enrolled 12 charts

Head & NeckOther

Squamous Cell Carcinoma of Head and Neck, Deglutition Disorders, Head and Neck Neoplasms, Radiation Injuries, Salivary Gland Neoplasms, Xerostomia, Mucositis

NCT00591149 2017-06-14

Oxaliplatin and Docetaxel Followed by Cetuximab for Head and Neck Cancer

Phase 2 Terminated

16 enrolled 5 charts

Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasms, Neoplasms, Squamous Cell

NCT00423150 2017-06-08

Phase 2 Study of Temozolomide in Pre-Selected Advanced Aerodigestive Tract Cancers (Study P04273AM2)(TERMINATED)

Phase 2 Terminated

86 enrolled 6 charts

GastrointestinalHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Colorectal Neoplasms

NCT01794845 2017-05-11

Cetuximab + Taxotere With Low Dose Fractionated Radiation for Head and Neck Carcinoma

Phase 2 Terminated

5 enrolled 9 charts

Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Recurrence

NCT00490061 2017-03-06

Lapatinib and Radiation for Stage III-IV Head and Neck Cancer Patients Who Cannot Tolerate Concurrent Chemotherapy

Phase 2 Terminated

17 enrolled 7 charts

Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT00101075 2017-02-27

Title XELOX FOR SALIVARY GLAND CANCERS

Phase 2 Terminated

9 enrolled

Head & Neck

Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT00256295 2017-02-01

Weekly Oxaliplatin and Gemcitabine for Recurrent or Metastatic Head and Neck Cancer

Phase 2 Terminated

8 enrolled 7 charts

Head & Neck

Head and Neck Neoplasms

NCT02281006 2017-01-27

STS001

Phase 2 Terminated

13 enrolled

Head & Neck

Head and Neck Neoplasms

Clinical Trials

Immune Modulation by Abemaciclib in Head and Neck Squamous Cell Carcinoma (HNSCC). (AIM Trial)

NIRADO

PAVO

BelieveIT-201

The Role of 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Cancers: a Pilot Trial

CMP-001 in Combination With Pembrolizumab in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Use of Cone Beam Kilovoltage Imaging in Patients Receiving Radiation Therapy for Head and Neck Cancer

Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors

ASP-1929 Photoimmunotherapy Combined With Pembrolizumab in Patients With Recurrent Head and Neck Cancer, With or Without Metastases

A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma

To Determine Safe and Effective Dose of Sotatercept for the Treatment of Chemotherapy Induced Anemia in Participants With Advanced Non-small Cell Lung Cancer

Bempegaldesleukin (NKTR-214) With Radiation and Anti-PD-1 Immunotherapy for Head and Neck Squamous Cell Carcinoma

Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer

ALpha-T

To Evaluate the Efficacy and Safety of SCB01A in Subjects With r/m Squamous Cell Head and Neck Cancer

NR in Chemo-induced Peripheral Neuropathy

ELDORANDO

Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer

Pemetrexed and Gemcitabine in Patients With Advanced Head and Neck Cancer

Utility of Restrata With Split-thickness Skin Graft to Reconstruct the Forearm Donor Site

A Study to Evaluate the Safety and Efficacy of Amphinex Induced PCI of Bleomycin for Recurrent Head and Neck Cancer.

Surgery, Radiation Therapy, and Combination Chemotherapy in Treating Patients With Recurrent Head and Neck Cancer

Efficacy and Safety Trial of ADU-S100 and Pembrolizumab in Head and Neck Cancer

Ph 2 Intensification Regimen for Previously Untreated, Resectable, Advanced Squamous Cell Cancer

Abemaciclib and Pembrolizumab in Metastatic or Recurrent Head and Neck Cancer

Safety and Efficacy of ALD518 for Reducing Oral Mucositis in Head and Neck Cancer Subjects

Study of Radiation (RT) Concurrent With Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (SCC)

EXTAX

Study in Locally Advanced Squamous Cell Carcinoma of Head and Neck

Everolimus Versus Placebo in Head and Neck Cancer

ORKA

Benefits of MPACT in Locally Advanced Head and Neck Cancer Patients Undergoing Chemoradiotherapy

Dexamethasone for Treatment of Radiation-related Fatigue in Patients Receiving RT for Head-neck and Lung Cancer

Maintenance of Tarceva (Erlotinib) in Patients With Locally Advanced Head and Neck Cancer

Patritumab With Cetuximab and a Platinum Agent for Squamous Cell Carcinoma (Cancer) of the Head and Neck (SCCHN )

Irinotecan in Treating Patients With Metastatic or Inoperable Thyroid Cancer

Cetuximab, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer That Cannot Be Removed By Surgery

Adjuvant Chemoradiation With Weekly Oxaliplatin in Resected Head and Neck Cancer

CTXMAB+RT

Study of Albumin Bound-Paclitaxel for Treatment of Recurrent or Metastatic Head and Neck Cancer With Cetuximab

Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer

Antineoplaston Therapy in Treating Patients With Advanced Head and Neck Cancer

Chemo/XRT +/- Amifostine to Assess Outcomes Related to Xerostomia, Mucositis, & Dysphagia

Oxaliplatin and Docetaxel Followed by Cetuximab for Head and Neck Cancer

Phase 2 Study of Temozolomide in Pre-Selected Advanced Aerodigestive Tract Cancers (Study P04273AM2)(TERMINATED)

Cetuximab + Taxotere With Low Dose Fractionated Radiation for Head and Neck Carcinoma

Lapatinib and Radiation for Stage III-IV Head and Neck Cancer Patients Who Cannot Tolerate Concurrent Chemotherapy

Title XELOX FOR SALIVARY GLAND CANCERS

Weekly Oxaliplatin and Gemcitabine for Recurrent or Metastatic Head and Neck Cancer

STS001