Clinical Trials

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00003809 2026-02-27

Cisplatin With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic or Recurrent Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05386550 2026-02-19

Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)

166 enrolled 15 charts

Head and Neck Neoplasms, Laryngeal Diseases

NCT04967391 2026-02-18

Tumescence in HNC Skin Graft Reconstruction

58 enrolled

Head and Neck Neoplasms

NCT03040999 2026-02-04

KEYNOTE-412

804 enrolled 20 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT01302834 2026-01-12

Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer

Head & NeckOther neoplasm

987 enrolled 59 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Precancerous Conditions, Papillomavirus Infections

NCT01856478 2026-01-12

LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy

340 enrolled 23 charts

Head and Neck Neoplasms

NCT07333274 2026-01-12

Compare Radiotherapy Plus Nimotuzumab Versus Radiotherapy Alone in Platinum-ineligible Patients With Locoregionally Advanced Head and Neck Squamous Cell Carcinoma

335 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00956007 2026-01-06

RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer

702 enrolled 35 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Tongue Neoplasms

NCT06690346 2026-01-06

Systematic Oral Education for Prevention of Oral-related Complications Caused by Radiotherapy for Head and Neck Cancer

150 enrolled

Head and Neck Neoplasms

NCT06998069 2025-12-30

Head and Neck Cancer Study Project in the Geriatric Population

20 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03358472 2025-12-03

Pembrolizumab Plus Epacadostat, Pembrolizumab Monotherapy, and the EXTREME Regimen in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-669/ECHO-304)

89 enrolled 14 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05333523 2025-11-24

PRIMO

242 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT02918955 2025-11-20

UPFRONT-NECK

65 enrolled

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Oropharyngeal Neoplasms

NCT02442375 2025-11-18

UPGRADE-RT

300 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT06706401 2025-11-18

Lysari

460 enrolled

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Oropharyngeal Neoplasms

NCT04338399 2025-11-17

BURAN

487 enrolled

Head and Neck Neoplasms

NCT00765440 2025-09-30

Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract

311 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Infections, Tongue Neoplasms, Malnutrition

NCT06256588 2025-09-25

JADE

864 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05273307 2025-09-22

Addressing Taste Dysfunction With Miraculin in Head and Neck Cancer Patients Receiving Radiation Therapy

40 enrolled

Head and Neck Neoplasms, Taste Disorders

NCT06055257 2025-09-12

Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible

24 enrolled

Head and Neck Neoplasms, Osteoradionecrosis

NCT03765918 2025-08-20

MK-3475-689

714 enrolled 90 charts 3 FDA

Parkinson Disease 4, Autosomal Dominant Lewy Body, Head and Neck Neoplasms

NCT02358031 2025-07-18

MK-3475-048

882 enrolled 50 charts 2 FDA

Parkinson Disease 4, Autosomal Dominant Lewy Body, Head and Neck Neoplasms

NCT05078047 2025-06-05

MOIO

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & Neck

646 enrolled

Esophageal Squamous Cell Carcinoma, Carcinoma, Basal Cell, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Melanoma, Carcinoma, Merkel Cell, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT04178174 2025-05-18

SHORT-OPC

360 enrolled

Phase 3 Not yet recruiting

Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT06957938 2025-05-08

Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma

168 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms

NCT02999087 2025-05-07

REACH

707 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT01345084 2025-03-28

NICAP

Phase 3 Withdrawn

Carcinoma, Head and Neck Neoplasms

NCT06737822 2025-03-04

SurVIC

346 enrolled

Head and Neck Neoplasms, Mouth Neoplasms

NCT01504815 2025-01-29

ARTFORCE

268 enrolled

Head and Neck Neoplasms

NCT03769506 2025-01-16

ASP-1929 Photoimmunotherapy (PIT) Study in Recurrent Head/Neck Cancer for Patients Who Have Failed at Least Two Lines of Therapy

135 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03840421 2025-01-13

GP Vs PF As Induction Chemotherapy Combined with CCRT for Locoregionally Advanced Nasopharyngeal Carcinoma

468 enrolled

Nasopharyngeal Carcinoma, Head and Neck Neoplasms, Nasopharyngeal Diseases, Nasopharyngeal Neoplasms

NCT04176419 2024-11-12

Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery

30 enrolled

Head and Neck Neoplasms

NCT04428333 2024-10-09

INDUCE-4

117 enrolled 33 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03747562 2024-09-19

stREnGTH

Phase 3 Withdrawn

Head and Neck Neoplasms, Neuralgia

NCT04128696 2024-07-10

INDUCE-3

315 enrolled 31 charts

Head and Neck Neoplasms, Neoplasms

NCT06327139 2024-03-25

OPEN

Phase 3 Unknown

201 enrolled

Head and Neck Neoplasms

NCT00415233 2023-12-19

HiLo

Phase 3 Unknown

438 enrolled

EndocrineHead & Neck

Thyroid Cancer, Papillary, Head and Neck Neoplasms, Adenocarcinoma, Follicular

NCT03689712 2023-10-24

ROMAN: Phase 3 Trial Investigating the Effects of GC4419 on Radiation Induced Oral Mucositis in Head/Neck Cancer Patients

455 enrolled 11 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Stomatitis, Oral Ulcer

NCT02741570 2023-09-21

CheckMate 651

947 enrolled 19 charts