Clinical Trials

Head and Neck Neoplasms, Hearing Disorders, Laryngeal Diseases, Speech, Hearing Loss

NCT04247282 2025-07-16

Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection

Phase 1/2 Completed

21 enrolled 16 charts

Head and Neck Neoplasms

NCT05879484 2025-07-10

Study of Front Line Pembrolizumab and Valemetostat in PD-L1 Positive, HPV-Negative Recurrent/Metastatic Squamous Cell Carcinoma (SCC) of the Head and Neck: The PANTHERAS

Phase 1/2 Withdrawn

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Lung Neoplasms

NCT03225157 2024-05-24

Hearing Loss and the Effects of Statin Drugs in People With Head and Neck Squamous Cell Carcinoma Treated With Cisplatin Chemoradiation

Completed

32 enrolled

Head and Neck Neoplasms, Hearing Disorders, Hyperlipidemias

NCT00099021 2022-02-11

Pioglitazone Hydrochloride in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia

21 enrolled 6 charts

Head and Neck Neoplasms, Leukoplakia, Oral

NCT02017288 2021-02-08

Study to Evaluate the Natural History of Head and Neck Cancer Precursors in Taiwan

Completed

3,576 enrolled

Head and Neck Neoplasms, Laryngeal Diseases

NCT00011492 2020-11-27

Patient Evaluation for Head and Neck Surgery Branch Studies

Terminated

62 enrolled

Phase EARLY_PHASE1 Terminated

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Pharyngeal Neoplasms, Neoplasms, Squamous Cell

NCT01479348 2020-06-02

Imaging Study for FdCyd and THU Cancer Treatment

5 enrolled 12 charts

BreastGenitourinaryHead & NeckThoracic

Urinary Bladder Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Neoplasms

NCT00978250 2019-12-27

A Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine (FdCyd + THU)

BreastGenitourinaryHead & NeckThoracic

95 enrolled 15 charts

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Lung Neoplasms

NCT01445405 2019-12-17

Radiation Therapy and Bortezomib and Cetuximab With or Without Cisplatin to Treat Head and Neck Cancer

3 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Pharyngeal Neoplasms

NCT00011778 2019-12-12

PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck

25 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT00924092 2019-12-12

An Open Label Phase I Study to Eval the Safety and Tolerability of a Vaccine (GI-6207) Consisting of Whole, Heat-killed Recombinant Saccharomyces Cerevisiae (Yeast) Genetically Modified to Express CEA Protein in Adults With Metastatic CEA-expressing ...

BreastGastrointestinalGenitourinaryHead & NeckThoracic

25 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms

NCT00372320 2018-09-11

Effect of AdhAQP1 on Salivary Flow in Patients Treated With Radiation for Head and Neck Cancer

17 enrolled

Adenoviridae Infections, Head and Neck Neoplasms, Xerostomia

NCT01195922 2017-12-06

Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma

Phase 1/2 Completed

37 enrolled 6 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Tongue Neoplasms

NCT00409565 2017-10-20

A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer

48 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT00100204 2017-07-02

Salivary Proteins in Disease and Health

Completed

264 enrolled

Cystinosis, Dental Caries, Diabetes Mellitus, Head and Neck Neoplasms, Sarcoidosis, Sjogren's Syndrome

NCT00571883 2015-12-14

Neck Surgery in Treating Patients With Early-Stage Oral Cancer

Phase NA Unknown

652 enrolled

Head and Neck Neoplasms, Tongue Neoplasms

NCT00923481 2015-09-30

A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H...

EndocrineGastrointestinalGenitourinaryHead & NeckThoracic

37 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Neoplasms, Pheochromocytoma, Colorectal Neoplasms

NCT00337129 2015-08-25

S0618 E7389 in Treating Patients With Metastatic or Recurrent Head and Neck Cancer

42 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00088907 2015-05-06

Phase III Trial Of Docetaxel Versus Docetaxel Plus ZD1839 In Head And Neck Cancer

Phase 3 Terminated

270 enrolled 8 charts

Head and Neck Neoplasms

NCT00006981 2015-04-30

Immunotoxin Therapy in Treating Patients With Advanced Cancer

GastrointestinalGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Brenner Tumor, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms

NCT00021424 2015-04-30

Vaccine Therapy in Treating Patients With Stage IV Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasm Metastasis

NCT00066651 2015-04-30

Immunotoxin Therapy in Treating Patients With Advanced Solid Tumors

GastrointestinalGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Brenner Tumor, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms

NCT00019110 2015-04-29

Vaccine Therapy in Treating Patients With Advanced or Recurrent Cancer

CNSGastrointestinalGenitourinaryGynecologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Penile Neoplasms, Salivary Gland Neoplasms, Vulvar Neoplasms, Esthesioneuroblastoma, Olfactory

NCT00019201 2015-04-29

Fluorescent Light Bronchoscopy Plus White Light Bronchoscopy for Early Detection of Lung Cancer

Phase NA Completed

Head & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms

NCT00022373 2014-10-15

Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Radiation Injuries, Salivary Gland Neoplasms

NCT00316823 2014-02-24

Genetic Analysis in Diagnosing Thyroid Cancer in Patients With Thyroid Nodules

Phase NA Completed

400 enrolled

Head and Neck Neoplasms, Thyroid Neoplasms

NCT00415298 2014-01-10

AP5346 or Oxaliplatin in Treating Patients With Metastatic and/or Unresectable Recurrent Head and Neck Cancer

Phase NA Unknown

12 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00004094 2014-01-06

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Previously Untreated Advanced Cancer of the Mouth, Pharynx, or Larynx

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00098852 2014-01-06

Rosiglitazone in Treating Patients With Locoregionally Extensive or Metastatic Thyroid Cancer

25 enrolled

EndocrineHead & Neck

Thyroid Cancer, Papillary, Head and Neck Neoplasms, Thyroid Neoplasms, Adenocarcinoma, Follicular

NCT00002659 2013-12-19

Cisplatin Plus Epinephrine in Treating Patients With Recurrent or Refractory Head and Neck Cancer

120 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00003576 2013-12-19

Surgery and Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer That Can Be Removed During Surgery

Phase 3 Completed

200 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00003637 2013-12-19

Radiation Therapy Alone Compared to Radiation Therapy Plus Chemotherapy in Treating Patients With Previously Untreated Cancer of the Nasopharynx

200 enrolled

Head and Neck Neoplasms

NCT00003856 2013-12-19

Photodynamic Therapy in Treating Patients With Recurrent, Refractory, or Second Primary Head and Neck Cancer That Cannot Be Treated With Surgery or Radiation Therapy

75 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT00004062 2013-12-19

Azacitidine to Restore Thyroid Function in Patients With Persistent or Metastatic Thyroid Cancer

EndocrineHead & Neck

Thyroid Cancer, Papillary, Head and Neck Neoplasms, Thyroid Neoplasms, Adenocarcinoma, Follicular

NCT00334997 2013-12-19

Endoscopic Surgery or Radiation Therapy in Treating Patients With Stage 0, Stage I, or Stage II Laryngeal Cancer of the Glottis

50 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Neoplasms

NCT00022217 2013-12-18

Cisplatin-Epinephrine Injectable Gel Plus Paclitaxel and Carboplatin in Treating Patients With Recurrent Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT00589186 2013-12-18

Vaccine Therapy and Celecoxib in Treating Patients With Metastatic Nasopharyngeal Cancer

35 enrolled

Head and Neck Neoplasms

NCT00003182 2013-12-04

Cisplatin and Gemcitabine in Treating Patients With Advanced Squamous Cell Cancer of the Head and Neck

Phase 1/2 Unknown

40 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms

NCT00003251 2013-12-04

Amifostine Plus Chemotherapy and Radiation Therapy in Treating Patients With Advanced, Unresectable Head and Neck Cancer

Phase 1/2 Unknown

46 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Radiation Injuries, Salivary Gland Neoplasms, Drug-Related Side Effects and Adverse Reactions

NCT00003257 2013-12-04

Gene Therapy in Treating Patients With Recurrent Head and Neck Cancer

39 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00004226 2013-12-04

Radiation Therapy Following Surgery in Treating Patients With Recurrent or Second Primary Cancer of the Head and Neck Following Previous Radiation Therapy

Phase 1/2 Unknown

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00004256 2013-11-06

Sargramostim to Prevent Mucositis in Patients Receiving Radiation Therapy for Laryngeal Cancer

Head and Neck Neoplasms, Laryngeal Neoplasms, Radiation Injuries

NCT00002747 2013-09-20

Surgery and Radiation Therapy With or Without Chemotherapy in Treating Patients With Mouth Cancer

240 enrolled

Head and Neck Neoplasms

NCT00004097 2013-09-20

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced and/or Recurrent Head and Neck Cancer

Phase 1 Unknown