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Phase

Phase 2 14Phase NA 9Phase 3 5Phase 1/2 5Phase 1 5Phase EARLY_PHASE1 3

Status

Active not recruiting 3Terminated 1Recruiting 1

Sponsor Class

OTHER 2INDUSTRY 2NIH 1

Study Type

Interventional 5

Sponsor

Cancer Type

Plasma cell 5

Conditions

Carcinoma, Non-Small-Cell Lung 374Neoplasms 325Neoplasm Metastasis 289Leukemia, Myeloid, Acute 282Breast Neoplasms 276Colorectal Neoplasms 238Melanoma 196Ovarian Neoplasms 192Recurrence 185Multiple Myeloma 180Prostatic Neoplasms 157Pancreatic Neoplasms 156Lung Neoplasms 156Squamous Cell Carcinoma of Head and Neck 150Lymphoma, Non-Hodgkin 145Glioblastoma 145Triple Negative Breast Neoplasms 119Myelodysplastic Syndromes 117Carcinoma, Renal Cell 111Stomach Neoplasms 110Advanced Solid Tumors 108Glioma 107Precursor Cell Lymphoblastic Leukemia-Lymphoma 104Brain Neoplasms 104Lymphoma 103Lymphoma, Large B-Cell, Diffuse 102Lymphoma, B-Cell 98Carcinoma, Hepatocellular 95Endometrial Neoplasms 92Lymphoma, Follicular 90

Interventions

dexamethasone acetate 3dexamethasone 21-phosphate 3auricularum 3Dexamethasone 3Calcium Dobesilate 3ixazomib 2venetoclax 1isatuximab 1daratumumab 1X-Rays 1Specimen Handling 1Phantoms, Imaging 1Magnetic Resonance Spectroscopy 1MLN2238 1Cyclophosphamide 1Bortezomib 1Biopsy 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Phase 1 × Immunoglobulin Light-chain Amyloidosis × 1 year × Clear all
NCT05839626 2026-05-27

A Study to Investigate Safety and Efficacy With SAR445514 in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) and Relapsed/Refractory Light-chain Amyloidosis (RRLCA)

Sanofi

Phase 1 Terminated
32 enrolled
Plasma cell

Immunoglobulin Light-chain Amyloidosis, Multiple Myeloma

NCT04847453 2026-05-13

Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis

National Cancer Institute (NCI)

Phase 1 Active not recruiting
24 enrolled
Plasma cell

Immunoglobulin Light-chain Amyloidosis

NCT07250269 2026-04-28

Study of GC012F, CAR-T Therapy Targeting CD19 and BCMA in Chinese Participants With Relapsed or Refractory AL Amyloidosis

Gracell Biotechnologies (Shanghai) Co., Ltd.

Phase 1 Recruiting
9 enrolled
Plasma cell

Immunoglobulin Light-chain Amyloidosis

NCT03283917 2026-02-27

Daratumumab, Ixazomib, and Dexamethasone in AL Amyloidosis

M.D. Anderson Cancer Center

Phase 1 Active not recruiting
21 enrolled
Plasma cell

Immunoglobulin Light-chain Amyloidosis

NCT04754945 2026-02-18

Isatuximab as Upfront Therapy for the Treatment of High Risk AL Amyloidosis

Emory University

Phase 1 Active not recruiting
11 enrolled
Plasma cell

Immunoglobulin Light-chain Amyloidosis

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