Announcements Trials
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Phase

Phase 2 1Phase 1 1

Status

Completed 2

Sponsor Class

OTHER 1NIH 1

Study Type

Interventional 2

Sponsor

Cancer Type

Thoracic 2Gynecologic 2Genitourinary 2Dermatologic 2Breast 2Other hematologic neoplasm 1Lymphoid 1Gastrointestinal 1

Conditions

Polycystic Ovary Syndrome 91Breast Neoplasms 21Insulin Resistance 18Obesity 14Prostatic Neoplasms 10Pancreatic Neoplasms 8Endometrial Neoplasms 7Neoplasms 6Infertility 6Anovulation 6Neoplasm Metastasis 5Colorectal Neoplasms 5Rectal Neoplasms 4Hyperandrogenism 4Weight Loss 3Squamous Cell Carcinoma of Head and Neck 3Precursor Cell Lymphoblastic Leukemia-Lymphoma 3Lung Neoplasms 3Leukemia, Lymphocytic, Chronic, B-Cell 3Hyperinsulinism 3Head and Neck Neoplasms 3Diabetes Mellitus, Type 2 3Diabetes Mellitus 3Carcinoma, Non-Small-Cell Lung 3Uterine Cervical Neoplasms 2Recurrence 2Rare Diseases 2Premature Birth 2Overweight 2Ovarian Neoplasms 2

Interventions

aldesleukin 26Sunitinib 25Interferon-alpha 21Everolimus 18Sorafenib 16Cyclophosphamide 16Filgrastim 13Bevacizumab 13Nivolumab 11Gemcitabine 11Interleukin-2 10Axitinib 10fludarabine phosphate 9Gene Expression Profiling 9temsirolimus 8Peripheral Blood Stem Cell Transplantation 8Doxorubicin 8pembrolizumab 7Radiotherapy 6Radiosurgery 6Polymerase Chain Reaction 6Ipilimumab 6Carboplatin 6sargramostim 5Ifosfamide 5Fluorouracil 5Erlotinib Hydrochloride 5Capecitabine 5Bortezomib 5atezolizumab 4

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Completed × Kidney Neoplasms × Metformin × Clear all
NCT02431676 2024-08-28

SPIRIT

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Phase 2 Completed
121 enrolled 12 charts
BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT00659568 2013-05-30

Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma

National Cancer Institute (NCI)

Phase 1 Completed
28 enrolled
BreastDermatologicGenitourinaryGynecologicLymphoidOther hematologic neoplasmThoracic

Breast Neoplasms, Burkitt Lymphoma, Carcinoma, Renal Cell, Hodgkin Disease, Immunoblastic Lymphadenopathy, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Endometrial Neoplasms, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Small Cell Lung Carcinoma

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