Announcements Trials
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Phase

Phase 2 1

Status

Completed 1

Sponsor Class

INDUSTRY 1

Study Type

Interventional 1

Sponsor

Cancer Type

Other hematologic neoplasm 1Myeloid 1Lymphoid 1

Conditions

Mastocytosis, Systemic 4Neoplasm Metastasis 2Systemic Mastocytosis With an Associated Hematologic Neoplasm 1Sarcoma 1Recurrence 1Neoplasm, Residual 1Melanoma 1Mastocytosis 1Lung Neoplasms 1Leukemia, Myeloid, Acute 1Leukemia, Mast-Cell 1Glioma 1Gastrointestinal Stromal Tumors 1Colorectal Neoplasms 1Central Nervous System Neoplasms 1

Interventions

fludarabine phosphate 1fludarabine 1avapritinib 1Whole-Body Irradiation 1Valganciclovir 1Thiotepa 1Therapeutics 1Tacrolimus 1Positron-Emission Tomography 1Polymerase Chain Reaction 1Methotrexate 1Ganciclovir 1Foscarnet 1Flow Cytometry 1Cyclophosphamide 1Busulfan 1Bone Marrow Transplantation 1Antiviral Agents 1

Date Range

30 days90 days1 yearAll

Options

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Clinical Trials

1 trials
RecentStart dateEnrollment
Leukemia, Mast-Cell × avapritinib × 1 year × Clear all
NCT03580655 2026-04-24

(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

Blueprint Medicines Corporation

Phase 2 Completed
107 enrolled 30 charts 1 FDA
LymphoidMyeloidOther hematologic neoplasm

Leukemia, Mast-Cell, Mastocytosis, Systemic

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