Announcements Trials
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Phase

Phase 2 1Phase 1 1

Status

Completed 2

Sponsor Class

INDUSTRY 2

Study Type

Interventional 2

Sponsor

Cancer Type

Other hematologic neoplasm 2Myeloid 2Lymphoid 2

Conditions

Gastrointestinal Stromal Tumors 6Recurrence 3Mastocytosis, Systemic 2Leukemia, Mast-Cell 2Sarcoma 1Neoplasms 1Glioma 1Glioblastoma 1Central Nervous System Neoplasms 1

Interventions

fludarabine phosphate 5Mycophenolic Acid 5Cyclosporine 5Whole-Body Irradiation 4Peripheral Blood Stem Cell Transplantation 4Therapeutics 3midostaurin 2avapritinib 2Psychiatric Rehabilitation 2Early Intervention, Educational 2Darbepoetin alfa 2thymoglobulin 1ripretinib 1liposomal doxorubicin 1hydrocortisone valerate 1ferrous sulfate 1ferric gluconate 1denileukin diftitox 1Sunitinib 1Sucrose 1Rituximab 1Pemetrexed 1Music Therapy 1Methylprednisolone Hemisuccinate 1Methylprednisolone Acetate 1Methylprednisolone 1Methotrexate 1Massage 1MK 2206 1Leucovorin 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Completed × Leukemia, Mast-Cell × avapritinib × Clear all
NCT03580655 2026-04-24

(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

Blueprint Medicines Corporation

Phase 2 Completed
107 enrolled 30 charts 1 FDA
LymphoidMyeloidOther hematologic neoplasm

Leukemia, Mast-Cell, Mastocytosis, Systemic

NCT02561988 2023-03-17

(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies

Blueprint Medicines Corporation

Phase 1 Completed
86 enrolled 1 FDA
LymphoidMyeloidOther hematologic neoplasm

Leukemia, Mast-Cell, Recurrence, Mastocytosis, Systemic

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