Announcements Trials
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Phase

Phase 2 2Phase 1 1

Status

Completed 3Terminated 2

Sponsor Class

INDUSTRY 2OTHER 1

Study Type

Interventional 3

Sponsor

Cancer Type

Other hematologic neoplasm 3Myeloid 1

Conditions

Melanoma 37Neoplasms 30Colorectal Neoplasms 8Carcinoma, Non-Small-Cell Lung 8Triple Negative Breast Neoplasms 5Pancreatic Neoplasms 5Neoplasm Metastasis 5Rectal Neoplasms 3Multiple Myeloma 3Leukemia, Myeloid, Acute 3Glioma 3Colonic Neoplasms 3Breast Neoplasms 3Biliary Tract Neoplasms 3Thyroid Neoplasms 2Sarcoma 2Parkinson Disease 4, Autosomal Dominant Lewy Body 2Oligodendroglioma 2Lung Neoplasms 2Hematologic Neoplasms 2Glioblastoma 2Cholangiocarcinoma 2Brain Neoplasms 2Astrocytoma 2Adenocarcinoma of Lung 2Adenocarcinoma 2Thyroid Carcinoma, Anaplastic 1Thyroid Cancer, Papillary 1Solid Tumors 1Skin Neoplasms 1

Interventions

Cytarabine 272Cyclophosphamide 136fludarabine phosphate 127Azacitidine 117Peripheral Blood Stem Cell Transplantation 95Busulfan 93Filgrastim 80Decitabine 79fludarabine 78Mycophenolic Acid 78Idarubicin 76Etoposide 76Whole-Body Irradiation 75Daunorubicin 72Tacrolimus 71Cyclosporine 64Methotrexate 62Mitoxantrone 57Clofarabine 55Antilymphocyte Serum 55Granulocyte Colony-Stimulating Factor 51Gemtuzumab 50Melphalan 49venetoclax 48Radiotherapy 30sargramostim 28Injections 25Bortezomib 25thymoglobulin 24aldesleukin 24

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
Completed × Leukemia, Myeloid, Acute × trametinib × Clear all
NCT04487106 2025-04-22

Azacitidine, Venetoclax, and Trametinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Higher-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

Phase 2 Completed
21 enrolled 14 charts
MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic

NCT02016729 2019-02-27

A Phase 1b Study Evaluating AMG 232 Alone and in Combination With Trametinib in Acute Myeloid Leukemia

Kartos Therapeutics, Inc.

Phase 1 Completed
36 enrolled
Other hematologic neoplasm

Neoplasms, Leukemia, Myeloid, Acute

NCT00920140 2014-04-02

Open-label Study to Evaluate the Safety, PK, and PD of MEK Inhibitor GSK1120212 in Subjects With Relapsed or Refractory Leukemias

GlaxoSmithKline

Phase 2 Completed
97 enrolled 23 charts
Other hematologic neoplasm

Neoplasms, Leukemia, Myeloid, Acute, Hematologic Neoplasms

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