Announcements Trials
Browse Landscape

Phase

Phase 2 5Phase NA 1Phase 3 1Phase 1 1

Status

Recruiting 2Active not recruiting 2Not yet recruiting 1

Sponsor Class

OTHER 4NIH 1

Study Type

Interventional 5

Sponsor

Cancer Type

Head & Neck 5

Conditions

Breast Neoplasms 547Carcinoma, Non-Small-Cell Lung 506Prostatic Neoplasms 332Colorectal Neoplasms 270Multiple Myeloma 266Neoplasms 260Leukemia, Myeloid, Acute 221Squamous Cell Carcinoma of Head and Neck 213Lung Neoplasms 206Neoplasm Metastasis 203Carcinoma, Hepatocellular 196Melanoma 172Triple Negative Breast Neoplasms 171Pancreatic Neoplasms 170Recurrence 152Ovarian Neoplasms 149Lymphoma 139Brain Neoplasms 132Glioblastoma 131Sarcoma 130Carcinoma, Renal Cell 126Leukemia, Lymphocytic, Chronic, B-Cell 124Head and Neck Neoplasms 124Stomach Neoplasms 122Lymphoma, Large B-Cell, Diffuse 122Rectal Neoplasms 107Precursor Cell Lymphoblastic Leukemia-Lymphoma 105Myelodysplastic Syndromes 102Uterine Cervical Neoplasms 100Urinary Bladder Neoplasms 100

Interventions

Metformin 3Specimen Handling 1Biopsy 1Aminolevulinic Acid 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Phase 2 × Leukoplakia, Oral × 1 year × Clear all
NCT05237960 2026-04-20

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

University of Arizona

Phase 2 Active not recruiting
34 enrolled
Head & Neck

Erythroplasia, Leukoplakia, Oral

NCT02581137 2026-04-13

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

National Cancer Institute (NCI)

Phase 2 Active not recruiting
26 enrolled 10 charts
Head & Neck

Erythroplasia, Hyperplasia, Leukoplakia, Oral, Mouth Neoplasms

NCT06876038 2026-03-19

Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions

University of Massachusetts, Boston

Phase 2 Not yet recruiting
65 enrolled
Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma in Situ, Leukoplakia, Oral, Mouth Neoplasms, Lichen Planus, Oral

NCT07387900 2026-02-06

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

Cairo University

Phase 2 Recruiting
34 enrolled
Head & Neck

Leukoplakia, Oral

NCT05727761 2025-12-24

Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia

University of Minnesota

Phase 2 Recruiting
36 enrolled
Head & Neck

Leukoplakia, Oral

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